The salient scope of this paper is to enable the knowledge and understanding of urban freight transportation and provide guidance for implementing sustainable policies and measures in a city. To achieve this goal, an evaluation framework for city logistics policies and measures is developed, which demonstrates the complexity of urban freight transportation systems, through selected performance indicators, taking into account divergent stakeholders’ interests, conflicting business models and operations. Evaluation follows a hierarchical process; sustainability disciplines (economy and energy, environment, transportation and mobility, society), applicability enablers (policy and measure maturity, social acceptance and users’ uptake), multiple criteria and indicators, capturing the lifecycle impact of policies and measures and multiple stakeholders. Apart from the multicriteria context, the framework embeds methodologies, including, Impact Assessment, Social Cost Benefit Analysis, Transferability and Adaptability, and Risk Analysis. To demonstrate its applicability a case study is set for the City of Graz assessing the establishment of an Urban Consolidation Center. Results show that there is an overall improvement of 2.2% in the Logistics Sustainability Index when comparing before and after implementation cases of the Urban Consolidation Center.