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The Antiglycation Effect of Monomethyl Branched Chained Fatty Acid and Phytochemical Compounds and their Synergistic Effect on Obesity Related Colorectal Cancer Cell Panel


Background and aims: monomethyl branched chain fatty acids (mmBCFA) and phytochemicals including: Hydroxycitric Acid, Chlorogenic Acid and Piperine have been considered as an interesting agent for researches due to their role in diabetes and cancer. The present study examines the antiglycation effect of mmBCFA and phytochemicals and investigate their Synergistic effect on different colorectal cancer cell lines.

Methods: This study was carried out by using murine monocyte-macrophage cell line and Methylglyoxal (MGO) to enhance the glycation process, furthermore to examine the antiproliferative effect of both the mmBCFA and phytochemicals we use Sulforhodamine B (SRB) assay against obesity related-colorectal cancer cell line panel.

Results: Both phytochemicals and mmBCFA have a higher antiglycation effect than Aminoguanidine (AMG) significantly, moreover, all of the phytochemicals and mmBCFA have antiproliferative against SW620, CACO2 and SW480, nevertheless none of these agents was equipotent to Cisplatin, furthermore, the synergetic effect observed only when we co-incubate Piperine with mmBCFA.

Conclusions: phytochemicals such as Hydroxycitric Acid, Chlorogenic Acid and Piperine and mmBCFA could be used as treatment to prevents the accumulation of advanced glycation end-products (AGEs) in diabetes. Furthermore, the co-incubation between these compounds can inhibit cancer growth, as alternative therapeutic strategy against obesity related-colorectal cancer.

Open access
Assessment of Common Risk Factors and Lifestyle Habits Associated with Atherogenic Risk and Lipid-Lowering Therapy in Men with Type 2 Diabetes


Background and aims: Our objective was to determine common risk factors and lifestyle habits associated with atherogenic risk and with the use of lipid-lowering therapy in men with type 2 diabetes.

Material and Methods: A comparative cross-sectional study was performed in the northwestern Algeria during eleven months on adult men patients with type 2 diabetes. Anthropometric parameters, blood pressures and lipid profile were evaluated. Data of common risk factors and lifestyle habits associated to atherosclerosis were compared between two groups according to the lipid lowering therapy use based on statins.

Results: 147 adult men patients with type 2 diabetes were involved in the study, 68 (46.26%) were under statins therapy and 79 (53.74%) were not. Significant associations with statins use were observed regarding the age group of 61-70 years (OR: 0.156 [0.043-0.570]; p=0.005), a salary of less than 30000 Algerian dinars (≈250.60$) (OR: 5.758 [1.299-25.512]; p=0.021), age of diabetes of 2-3 years (OR: 0.105 [0.013-0.867]; p=0.036) as well as with lipid ratios and body mass index (BMI). However, no significant associations were noted regarding the other studied parameters (marital status, educational level, occupation, salary, and family history, smoking status, alcohol consumption and sports practices) with lipid lowering therapy.

Conclusion: Age of patients, diabetes duration, lipid ratios and the low income of patients are the strongest factors associated with the use of lipid lowering therapy (statins). However, largest longitudinal studies are needed to determine whether modifiable lifestyle habits could influence the lipid lowering therapies prescription in diabetic patients over time.

Open access
Beneficial Effect of Pachyrhizus erosus Fiber as a Supplemental Diet to Counteract High Sugar-Induced Fatty Liver Disease in Mice


Background and aims: Edible fiber isolated from the tuber of yam bean (Pachyrhizus erosus, Leguminosae) has been suggested to prevent the development of metabolic diseases caused by excessively consuming sugary foods. However, it is unclarified whether P. erosus fiber (PEF) is also capable of preventing liver diseases. This study aimed to determine the effectivity of PEF in counteracting the development of non-alcoholic fatty liver disease (NAFLD) caused by excessive intake of high-sugar diet (HSD).

Material and method: 25% of PEF in HSD (w/w) was fed in BALB/c mice for eight weeks followed by subsequent morphological and histological examinations of the liver at the end of treatment in comparing with HSD alone.

Results: We found that supplementation of 25% PEF sustained the normal morphological feature of the liver in HSD-fed mice. Moreover, PEF also prevented the development of microvesicles in the liver tissue, nuclear shrinkage, and hepatolysis as indicators of liver disease. Macrophages infiltration as a marker of liver inflammation was also less observed in PEF-treated mice.

Conclusions: PEF could effectively elicit a beneficial effect against NAFLD caused by HSD. Hence, PEF is suggested to be used as a potent supplemental diet to preclude the metabolic diseases caused by HSD.

Open access
Comparison of Efficacy of Nortriptyline Versus Transcutaneous Electrical Nerve Stimulation on Painful Peripheral Neuropathy in Patients with Diabetes


Background and aims: Diabetic peripheral neuropathic pain (DPNP) is one of the most common complications of diabetes and is difficult to treat. Existing treatments are often inadequate at controlling pain and limited by side-effects and drug tolerance. This study assessed the efficacy of nortriptyline versus Transcutaneous Electrical Nerve Stimulation (TENS) in patients with DPNP.

Material and method: This is a randomized clinical trial study conducted on 39 patients with DPNP referring to Golestan Hospital in Ahvaz in 2017. Patients were randomly treated with TENS (18 sessions, each session 30 minutes; n=20) or nortriptyline (25 to 75 mg, once daily; n=19) for 6 weeks. Patients were evaluated for side effects and pain relief using visual analog scale (VAS).

Results: There was a significant improvement in pain with both treatments compared with baseline (p˂0.001). The patients in nortriptyline group experienced more pain relief (7.21±1.51 to 0.84±1.34) than the TENS group (7.6±1.47 to 2.75 ±2.43) (P=0.001). The 50% pain relief was observed in 14 patients (73%) in nortriptyline group, 6 patients (30%) in TENS group. Moreover, the side effects were seen in 15% of TENS and 55% of patients in nortriptyline groups (P=0.019).

Conclusion: Both TENS and nortriptyline were effective and safe in the management of DPNP. But nortriptyline showed a better performance on pain relief.

Open access
Effect of Health Coaching Approach Based on Motivational Interview on Improving Undesirable Nutritional Habits of Housewives


Background and aims: Nutrition disorders are a common risk factor for many clinical disorders, and effective methods for resolving it are motivational interviewing methods that can be useful in encouraging people to promote lifestyle. In recent years, motivational interviews have come up with community health and often people in need of a change in nutritional habits are so vast that they can maintain their health.

Material and method: This interventional study was carried out on all housewives referring to Mazdak Health home. They were selected by simple sampling method. The sample size was 35 in each subgroup. Food intake was assessed by a feed frequency questionnaire (FFQ) and the energy consumption in kilocalories per day was calculated using Nutritionist 4 software. Using SPSS18 and Chi-square tests, the exact test Fisher, T and Independent Tests, Mann-Whitney, and Wilcoxon were analyzed.

Results: The mean score of healthy nutrition index after intervention was significantly different in intervention and control groups (p-value = 0.004). Also, in whole grain (p-value = 0.001), dairy (p-value = 0.01) Fruits (p-value = 0.01), vegetables (p-value = 0.003) had a significant difference between the mean of intervention and control groups after intervention. There were no significant differences between the other indices after the intervention in the intervention and control groups.

Conclusions: The intervention has been effective and generally increases the index of healthy nutrition index after intervention. But on components of dairy, sodium, refined grains, absent calories, proteins have not had any effect.

Open access
The Quercetine Containing Drugs in Pharmacological Correction of Experimental Diabetes with Myocardial Injury


Background and aims: The prevalence of diabetes mellitus is becoming an epidemic. The diversity of etiological factors contributes to the fact that both types of diabetes mellitus occur among different age groups and among different segments of the population. Activation of various types of processes that lead to oxidative stress, endothelial dysfunction, the development of atherosclerotic changes, increases the risk of macro- and microvascular complications in diabetes mellitus.

Material and methods: The experiments were performed on 172 white Wistar rats weighing 120–150 g. All animals were kept on a standard I. Horbachevsky Ternopil National Medical University (TNMU), vivarium diet. In our studies, for the first time was established a distinct cardioprotective effect of quercetin-containing drugs, Corvitin and Lipoflavon, for the purpose of normalizing disorders in type 1 and type 2 diabetes mellitus coupled with obesity, which opens wide opportunities for the introduction of these drugs into diabetic cardiomyopathy.

Results: The results obtained are an experimental rationale for extending the indications of clinical use of Corvitin and Lipoflavon.

Conclusion: Lipoflavon in the experimental type 1 and type 2 diabetes mellitus coupled with obesity significantly outperforms Corvitin in terms of TBA-active products and diene conjugates.

Open access
Red Blood Cells Aggregation in the Patients with Type 2 Diabetes and T2D Associated Anemia, a Case Control Study in Bangladesh


Background and Aims: Type 2 Diabetes (T2D) is a chronic metabolic disorder. Nowadays the number of people with diabetes mellitus is quadrupling in the world as well as in Bangladesh. It is related to different types of disease morbidity and sociodemographic parameters. The present study aimed to investigate the association of RBC aggregation (measured by ESR level) with T2D and T2D associated anemia.

Material and method: A total of 234 subjects were included in the study. Sociodemographic and anthropometric information about study subjects were collected using a standard questionnaire. Blood samples were tested for random blood glucose levels, Hb percentage, and ESR. Association of these data with metabolic disorders was analyzed by statistical analysis software, SPSS.

Results: This study provides a piece of evidence that anemia is highly prevalent in T2D patients than the healthy control subjects in Bangladesh (59.1% vs 22.5%; P value <0.001). The ESR values were significantly elevated in T2D patients as well as anemic and aged subjects (P value <0.001).

Conclusion: The study thus suggests that anemia was prevalent in T2D patients in Bangladesh. The RBC aggregation was significantly elevated in patients with T2D as well as anemia, indicating increased inflammatory response in these diseases.

Open access
Relationships Between Serum Expression of IGF-1 and Metabolic Syndrome Metrics in Syrian Women with Breast Cancer


Background and aims: Insulin-like Growth Factors (IGF-1) plays as mediator between metabolic syndrome (MetS), oxidative stress and breast cancer (BrCa) progression. The objective of this study was to examine the relationships between IGF-1 serum levels and metabolic profile biomarkers in a population group of BrCa patients.

Material and methods: 126 Syrian women with breast lesions were assigned in 3 study groups: I. Malignant breast tumor group, II. Benign breast tumor group and a Normal (control) group. The following biochemical parameters were measured: IGF-1, HDL-cholesterol, LDL-cholesterol, triglycerides (TG) and glucose.

Results: The mean levels of serum IGF- 1 in patients with breast cancer was significantly higher than those with benign tumors but we did not find any correlation between IGF-1 serum levels and tumor stage or lymph nodes metastases. Total cholesterol and LDL-cholesterol levels, along with TG were significantly higher in patients with BrCa versus benign and normal subjects.

Conclusion: Results support the link of metabolic dysregulation and oxidative stress in BrCa progression as elevation of serum IGF-1 levels in BrCa patients are associated with metabolic syndrome markers which eventually adds more risk in cancer progression.

Open access
The Relative Risk of Developing Type 2 Diabetes Mellitus in Young Adults with Schizophrenia Treated with Different Atypical Antipsychotic


Background and aim: While the link between antipsychotic treatment and metabolic adverse events, including type 2 diabetes mellitus (T2DM) are clear in adults with schizophrenia, in young this association is not so well studied although the use of secondgeneration antipsychotics (SGA) is more and more frequent.

Material and methods: The local diabetes register was compared with the list of all registered young adults (18-35 years) with schizophrenia 2 years retrospective and 2 years prospective. Cumulative incidence, rate of incidence and relative risk was calculated knowing the number of persons in this age group within this region.

Results: Cumulative incidence for exposed group was 0.7% with a rate of incidence of 6.27 (95%CI: 4.1-10.5) per 1,000 patientyears, when in normal population was 0.2%, respectively 2.01 (95%CI: 0.72-3.79). This means a relative risk of 3.4736 (95%CI: 1.79-6.72), p=0.0002 and NNH=202 (95%CI: 134-404). Multivariate analysis showed that gender male (OR=1.83; 95%CI: 0.9-2.7; p=0.002) and olanzapine prescription (OR=4.76; 95%CI: 1.7-7.7; p=0.0001) were independent risk factors for T2DM.

Conclusions: The metabolic risk should be taken in account every time introducing or changing a SGA in young schizophrenic patient, balancing the benefits and negative metabolic effects (especially with olanzapine). Healthy nutrition and physical activities are necessary components of these patients lifestyle to avoid early onset of T2DM.

Open access