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Abstract

Background

The arylidene indanone scaffold has contributed many lead molecules in chemotherapeutic anticancer agent research.

Objectives

To determine the oxidant-scavenging activities and antiproliferative activity of (2E)-2-benzylidene-4,7-dimethyl-2,3-dihydro-1H-inden-1-one (MLT-401), an arylidene indanone derivative.

Methods

Jurkat cells, primary lymphocytes, and Vero cells were treated with MLT-401. Antioxidant properties of MLT-401 were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH)-based, 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS)-based, and ferric-reducing antioxidant potential (FRAP) assays. Inhibition of cell proliferation was determined using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide-based assay. Nuclear status was determined using a DNA fragmentation assay, and cell cycle stage was analyzed by flow cytometry. Mitochondrial membrane enzyme activities were measured using colorimetric methods.

Results

The antioxidant assays gave MLT-401 half maximal inhibitory concentration (IC50) values of 1611 nM (DPPH-based assay), 2115 nM (ABTS-based assay), and 1586 nM (FRAP assay). MLT-401 inhibited proliferation of Jurkat cells with a concentration for 50% of maximal inhibition of cell proliferation (GI50) of 341.5 nM, being 12- and 9-fold less than GI50 concentrations for normal lymphocytes and Vero cells, respectively. MLT-401 caused nuclear fragmentation and DNA laddering as seen by electrophoresis. Jurkat cells showed a time-dependent accumulation of sub G0/G1 cells after MLT-401 treatment. Mitochondrial membrane-bound Na+/K+ ATPase, Ca2+ ATPase, and Mg2+ ATPase activities were inhibited by MLT-401 in a dose-dependent manner.

Conclusion

MLT-401 possesses significant antiproliferative activity and scavenges free radicals released through mitochondrial membrane damage in a Jurkat cell line model of cancer cells. Further investigation of MLT-401 as a chemotherapeutic anticancer agent and development of other arylidene indanone analogues are warranted. A detailed elucidation of mechanistic pathways is required for further development.

Abstract

Postpartum fatigue is an important issue that threatens women’s health. The incidence of postpartum fatigue is high. Failure to intervene in time may lead to adverse outcomes such as postpartum depression, premature termination of breastfeeding, child abuse, and low infant development. This article reviews the concepts, characteristics, related factors, adverse effects, and interventions of postpartum fatigue. The aim is to improve doctors’ and nurses’ awareness of on postpartum fatigue in pregnant women, enrich the research content and methods, stimulate the interest of nurses, and actively carry out targeted intervention research to prevent or reduce the occurrence of adverse outcomes.

Abstract

Anxiety is often mentioned in people’s daily life, especially in the field of medicine and psychology. For nursing, a clear understanding of anxiety is conducive to clinical nursing practice and research. Under the guidance of the Walker and Avant method, this article conducts a concept analysis of anxiety that provides a comprehensive and rounded analysis of anxiety and helps nurses gain a better understanding of anxiety.

Abstract

Objective

To review and analyze the basic information and distribution of core articles in the global research frontier of nursing, so as to ascertain the current trend in the field.

Methods

A total of 37 highly cited essential science indicator (ESI) papers in the nursing discipline were retrieved, which were compared with the core article collection of the ESI research frontier in January 2019 to understand the current nursing research frontiers. Subsequently, a statistical analysis of the core articles that constituted the nursing research frontiers was performed using a bibliometric method. The analysis was conducted with multiple aspects including the number of core articles, total number of citations, average publication year, issuing country, participating institution, citing paper, journal distribution, and core researcher.

Results

At present, the two international research frontiers of nursing are patient-centered care (Research Frontier 1) and missed care (Research Frontier 2). These two frontiers include a total of 12 core articles, 6 of which are highly cited Web of Science-indexed nursing papers. Research Frontier 1 includes three core articles that were cited 389 times. Research Frontier 2 includes nine core articles that were cited 841 times. Articles in the two frontiers were cited by 454 and 841 papers, respectively, most of which are in the United States. In addition, the 12 core articles were published across eight journals, the impact factors of which are all relatively high. Lastly, Research Frontier 1 involves 11 authors, whereas Research Frontier 2 involves 49 authors, of which seven authors have published more than two articles.

Conclusions

The core articles in the frontier of international nursing research demonstrate distinctive features in their issuing country/region, journal distribution, and participating institution. Review and analysis of the core articles of international nursing research frontiers can help nursing staff understand the current research hotspots and consequently perform corresponding scientific research to promote the development of the nursing discipline.

Abstract

Objectives

To examine the perceived impact of international educational experiences and cultural beliefs before and after completing a 1-year Masters of Science in Nursing program.

Methods

An exploratory study was conducted among Chinese nurses studying abroad in a private medium-sized university in the United States. The 27-item electronic pre-survey was administered within 1 week of starting the program and the post-survey was administered 1 year later at the completion of the program.

Results

Majority of participants (n = 25) were female, 23–36 years of age. Findings revealed that the perceived impact of international educational experiences assessed at the start of the program was similar to the perceived impact measured at the end of the 1-year program, suggesting that the students learned and experienced what they anticipated. There was a significant impact on cultural beliefs from the start of the program compared with the end of the program suggesting that a 1-year study abroad program does influence cultural beliefs.

Conclusions

Understanding what is important to provide in a study abroad program and providing the educational experiences identified by students as impactful are avenues to help host universities best develop their programs. Findings suggested that the 1-year program can influence foreign students’ cultural beliefs, yet the professional and personal impact of this change warrants further study.

Abstract

Background

Serum starvation is mostly considered as a standard preparatory method in many cellular and molecular experiments. However, recent studies give some evidence that serum starvation is a major event that triggers various cell responses and has therefore great potential to change and interfere with the experimental results. In this study, the behavior of breast cancer cells in serum-starved condition was examined.

Objective

To focus on the role of serum starvation on cell migration and also the possible changes in the expression and secretion of genes and cytokines mostly involved in migration and chemotaxis of breast cancer cells.

Methods

MDA-MB-231 cells were cultured under serum-starved condition. Transwell migration assay was performed to evaluate the effect of serum starvation on cell migration after 24, 48, and 72 h. The transcriptional expression of migration-related genes was evaluated using real-time polymerase chain reaction. The cytokine secretion was also analyzed using enzyme-linked immunosorbent assay.

Results

Serum starvation suppressed cell migration in breast cancer cells. Additionally, the gene expression of markers involved in migration including β-catenin, twist, zinc finger E-box binding homeobox 1, vimentin, fibronectin, intercellular adhesion molecule 1, and vascular endothelial growth factor were downregulated. Moreover, cytokines of transforming growth factor, beta 1, matrix metallopeptidase 9, interleukin 8, and nitric oxide were differentially secreted.

Conclusions

Serum deprivation causes significant changes in cancer cell migration and also the expression of migration-related genes and cytokines, special care needs to be taken when this practice is used as preparatory method especially in migration and chemotaxis experiments on cancer cells.

Abstract

Objective

The aim of this study was to assess the effectiveness of mindfulness meditation (MM) on anxiety, depression, stress and mindfulness in nursing students.

Methods

A comprehensive search and screening procedures were conducted to locate all MM interventions implemented with nursing students. For randomized controlled trials (RCTs) in accordance with the inclusion criteria, a search was conducted in PubMed, Embase, Web of Science, Medline, PsycINFO, Cumulative Index to Nursing and Allied Health (CINAHL), Cochrane Central Register of Controlled Trials (CENTRAL), China Biology Medicine (CBM), Chinese National Knowledge Infrastructure (CNKI) and Wanfang. Databases were retrieved from inception through August 2018. Additional studies were identified through hand searches and Internet searches. Two reviewers collected relevant data of eligible articles according to the data extraction tables. Based on Cochrane Handbook, critical appraisal of the methodological quality was assessed by two other reviewers. An Excel form was used to extract main characteristics of included RCTs. Meta-analysis and trial sequential analysis (TSA) were carried out using software RevMan 5.3 and TSA 0.9.

Results

Five RCTs with 257 nursing students were included. Only two studies were assessed as high quality and three studies were evaluated as moderate quality. Meta-analysis showed that, comparing with the control group, MM could significantly improve anxiety (SMD = −0.45, 95% CI −0.73 to −0.17, P = 0.001) and stress (SMD = −0.69, 95% CI −0.97 to −0.40, P < 0.001). TSA results confirmed that the outcome of the merger is credible. It could also significantly improve depression level of nursing students after 8 weeks intervention duration (SMD = −0.70, 95% CI −1.14 to −0.26, P = 0.002). However, there was no beneficial effect on depression level of nursing students with 1 week intervention duration (SMD = 0.09, 95% CI −0.42 to 0.59, P = 0.74) and its effects on mindfulness level of nursing students also did not show statistical significance (SMD = 0.37, 95% CI −0.04 to 0.77, P = 0.07). No definitive conclusions were drawn from the TSA.

Conclusions

The results of this meta-analysis indicated that MM could effectively reduce the level of anxiety and stress of nursing students. TSA confirmed that the results of meta-analysis are credible. For depression, it could also significantly improve depression of nursing students with 8 weeks intervention, but there was no significant effect on nursing students with 1 week intervention duration. There was also no beneficial effect on mindfulness level of nursing students. However, TSA indicated that the accumulated evidence is still inconclusive. We suggest that more well-designed clinical trials with large sample and higher quality would be required in future to draw a definitive conclusion.

Abstract

Objective

This meta-analysis aimed to evaluate the effects of walking exercise on bowel preparation in patients undergoing colonoscopy.

Methods

PubMed, Web of Science, EMBASE, Ovid, The Cochrane Library, Wanfang Data, China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, and Chinese BioMedical Database were searched from their inception to January 2019. Randomized controlled trials (RCTs) and controlled clinical trials (CCTs) examining the effects of walking exercise in patients undergoing colonoscopy were considered for inclusion. After screening literature, extracting data and evaluating methodological quality, RevMan 5.3 software was used for meta-analysis.

Results

Five studies (four RCTs and one CCTs) involved 984 participants were included. The results of meta-analysis demonstrated that the walking exercise group showed significantly higher improvements in the rate of adequate bowel preparation than the control group (risk ratio [RR] = 1.28, 95% confidence interval [CI] [1.03–1.58], P < 0.05). In addition, the walking exercise group had lower incidence of vomiting (RR = 0.39, 95% CI [0.23–0.68], P < 0.01) and abdominal pain (RR = 0.51, 95% CI [0.29–0.90], P < 0.05) with lower heterogeneity.

Conclusions

This systematic review and meta-analysis provided specific evidence that walking exercise during bowel preparation can improve the rate of adequate bowel preparation and reduce the incidence of vomiting and abdominal pain in patients undergoing colonoscopy. Since the conclusion of this meta-analysis was drawn based on the limited number of high-quality RCTs, more rigorous RCTs should be conducted in the future.

Abstract

Objective

This study focuses on how leadership could influence the quality of care in a health-care organization.

Methods

The concept of leadership and quality are analyzed. In addition, issues concerning how leadership can influence quality of care through the effect on the organizational culture and the engagement of both nurses and patients are discussed.

Results

Leadership is the pivotal factor in the improvement of quality through the effect on the organizational culture and the engagement of both nurses and patients.

Conclusions

Leadership can influence the quality of care directly and indirectly. The organization and the leaders should know the importance of effective leadership to a better work environment, facilitate the implementation of the new mode of nursing, and provide best services to the patients.

Abstract

Objective

This study aimed to identify the mediation effects of health locus of control (HLC) and hope between stroke patients’ social support and self-management.

Methods

A cross-sectional study was conducted. A total of 300 Chinese stroke patients were recruited by convenient sampling from the acupuncture department of two Chinese Traditional Medical Hospitals in Tianjin Province from June to September 2018. The self-report questionnaires include Social Support Assessment Scale, Herth Hope Index, Mental Health Locus of Control Scale, Stroke Self-management Behavior Scale, and personal information questionnaires. All the survey data were entered in Excel and analyzed using the SPSS 24.0 program. Mediation was tested with Bootstrapping in AMOS 23.0 program.

Results

The result showed that internal health locus of control (IHLC), chance health locus of control (CHLC) and hope were the mediators between social support and self-management. The direct, indirect, and total effects of social support on self-management behavior were 0.306 P < 0.01), 0.109 (P < 0.01), and 0.415 (P < 0.01), respectively.

Conclusions

Social support can directly influence self-management, and it can also indirectly influence self-management through IHLC, CHLC, and hope.