Objective: The objective of the study was to determine the differences in selected clinical variables and self-image in people with alcohol dependence differing in severity of physical, emotional and sexual abuse experienced before age 18.
Method: The study included 90 people with alcohol dependence. The following research tools were used: Early Trauma Inventory (ETI), Adjective Check List (ACL), MAST, SAAD, and a questionnaire designed by the authors. In order to identify groups with varying indices of physical, emotional and sexual childhood abuse, a cluster analysis method was used.
Results: Two groups of subjects with alcohol dependence were identified: Group 1 with high indices of physical, emotional and sexual childhood abuse and Group 2 with low indices. In terms of self-image the subjects in Group 1 compared to subjects in Group 2 were characterized by a lower self-esteem, self-acceptance, resistance to stress, less intense needs for achievement, endurance, order, nurturing others, interaction with opposite-sex partners, subordinations but more intense need for change. The age of alcohol use initiation and the onset of regular alcohol drinking was statistically significantly lower in Group 1. The severity of alcohol dependence was significantly lower in Group 2. The subjects in Group 1 significantly more frequently confirmed the history of a hereditary predisposition to alcohol dependence, suicidal ideation, suicide attempts and self-harm.
Discussion: The obtained results closely correspond to the data available in the literature.
Conclusions: An assessment of exposure to various forms of childhood abuse appears to be an indispensable element of collecting medical history of people with alcohol dependence.
Fogarasi Erzsébet, Fülöp Ibolya, Berecz Zsuzsa, Márton Kincső and Croitoru Mircea Dumitru
Introduction: Camellia sinensis, a widely used plant, optimally grows in a low pH soil that in most cases contains high amounts of aluminum. Objectives: The aluminum content of the tea obtained from Camellia sinensis and other plants was compared. The influence of pH on the aluminum content of the tea was also measured. Materials and methods: The aluminum content of 48 samples was measured using a colorimetric method. The method is based on the ability of aluminum to form a stable complex with xylenol orange at low pH; this complex has an absorption maximum of 555 nm. Results: The method was validated for tea obtained with water and for tea obtained with water containing citric acid. The method proved linear over the rage of 0.7 – 7 ug/ml, coefficient of variation ranged between 2.6 – 7.68% (was dependent on the pH of the solution used to obtain the tea), accuracy was suitable for quantitative measurement (92.39-102.92%) and the complex proved to be stable for at least 1 hour. The following concentrations were measured: green tea (1.59 - 7.70 µg/ml), black tea (1.39 - 5.60 µg/ml), fruit tea (1.01 - 5.63 µg/ml) and herbal tea (1.03 - 5.24 µg/ml). Conclusion: The method proved useful and easily applicable for screening aluminum content of plants used for tea brewing. Camellia sinensis both green and black types had significantly higher aluminum contents than other type of teas. Adding citric acid, as would result from use of lemon juice, significantly increased the aluminum extraction from the plants used for tea brewing.
Kelemen Hajnal, Filep Bíborka-Erzsébet and Papp Lajos Attila
Triptans are specific drugs for migraine attack, their use leads to selective vasoconstriction, while the inflammatory condition that usually occurs during migraine is reduced. The structurally indolamine derivatives are selective agonists of the serotonin 1B/1D receptor. This review presents the history, representatives, production, and physico-chemical properties of triptans, but also discusses their pharmacological properties and mechanism of action.
Dénes Szabó (1856–1918) was the second professor of obstetrics and gynecology of the Franz Joseph University from Kolozsvár (Cluj). This is a centennial commemoration. Szabó was born in the family of a great geologist professor at Pest. He studied at the University from Budapest and Strasbourg. He took his doctor’s degree is 1879. He spent a year with medical studies in foreign countries. In 1881 he became assistant to Professor Tivadar Kézmárszky, head of the Gynecological Clinic No. I. from Budapest. He was qualified as private lecturer in gynecology in 1888. In this period he published a lot of studies and review articles in the weekly medical papers Orvosi Hetilap and Gyógyászat. The Kolozsvár professor of obstetrics János Maizner in 1892 got retired. As a result of a competition Szabó was appointed professor of both obstetrics and gynecology. Until 1899 he worked in very poor conditions in a suburb building. Then the new 2 floor hospital from Mikó Street was built, where there were separate sections for obstetrics and gynecology. There he could also train midwives during 5 month courses. He became member of the Medical section of Transylvanian Museum Society, from 1894 up to 1912 he was the editor of its review journal (Értesítő...). Most of his studies were published there. The Medical Faculty elected him three times dean, in 1905/6 he was the rector of the university. He published around 65 studies. Some of them discuss deontological problems or deal with medical history. He was one of the editors of two memorial volumes, one dedicated to Professor Purjesz (1906), the other to Professor Lechner (1915). He compiled the first history of the Medical Faculty in 1896. He was also one of the editors of the monographic album of the Kolozsvár University from 1903. Five of its chapters were written by him. He was awarded with the title of Court Counselor. During WWI he did much for the medical care of wounded soldiers, so he got military awards, too. A number of medical and civil associations elected him president. He died because of gastric cancer at a Budapest hospital. According to his final wish he was buried in the Házsongárd Cemetery
Bába László-István, Kolcsár Melinda, Hack Beatrix, Gáll Zsolt and Kun Imre Zoltán
The endocannabinoid system (ECS) received a lot of attention ever since its discovery. Advancements of the last three decades have shown that there are numerous mechanisms by which the ECS regulates the energy metabolism. These can either be central (regulating appetite and calorie expenditure) or peripheral (adipocyte-specific and other) mechanisms. The current review highlights some of the most important observations leading to the discovery of the ECS first, followed by a part detailing the synthesis and transport of these mediators, the receptor types and second messenger systems involved. The next part is dedicated to the mechanisms by which this system regulates the energy metabolism. Lastly, the drugs that reached the clinical phase and the main targets and strategies for future drug development will be reviewed.
In Kolozsvár, on 17th of September 1872, a Hungarian royal university was founded with 4 faculties 1- Law and Political Sciences, 2. Medical, 3. Arts (liberal), Language and History of Science, 4. Mathemathics and Natural History faculties. In 1881 the University picked up the Ferencz József University of Science name. There was no independent Medicine trainingfacultyt at this time yet. Pharmacists were taught in the Medical and Natural History faculties. In December 1918, during the first world war, Kolozsvár was moved under Romanian rule. On the 9th of May in 1919 the Romanian authorities called the acadamic senate (school staff) to do loyalty oath for the Romanian king.This was refused by the university teachers. After this event, teachers were moved out from this building along with the entire equipement of the University, and the place was occupied by the Romanian university. As, by this, theHungarian language acadamic education became impossible the first stage of the life of(Hungarian King) Ferencz József University of Sciense ended. First, the major part of theprofessors and students emigrated to Budapest while later on in 1921 the University wastemporarily established in Szeged. The University in Szeged took not onlythe legal continuity of the institute through its name but its professors also maintained and cherished all the traditions of the institute through many long coming years. Starting from 1921/1922 many student with transilvanian origin obtained pharmacist’s degree here many of whom later returned and worked in their native country.
Tibor Széki pharmacist, professor of pharmacy, member of the Hungarian Academy of Science, co-worker at Kolozsvár University, rector at Szeged University, professor of Budapest. He was a talented teacher, intuitive researcher, well organizing (founder of several institutes of chemistry) and public personality. His importance is beyond dispute in development of Hungarian chemical education.
Rédai Emőke, Zsombori Mónika, Székely-Szentmiklósi Blanka and Sipos Emese
The aim of this experimental work was the enhancement of water solubility of the lipid lowering atorvastatin, by embedding it in polymer based micro sized fibers obtained by electrospinning. We prepared a polyvinylpyrrolidone (Kollidon 90F®) dispersion and added the active substance. By setting the experimental parameters we obtained four different microfibers containing atorvastatin, and one without the drug. The pH, viscosity and conductivity of the dispersions have been measured. The drug content and dissolution of atorvastatin had been studied by capillary electrophoresis. The size and thermal behavior of the fibers was determined. The parameters of the microfibers are influenced by the experimental parameters of electrospinning. The micro-method for dissolution showed a twofold solubility enhancement.
Vascular-ventricular coupling is a major determinant of left ventricular load. The aim of our study was to assess non- invasively left ventricular load and its dependency on central hemodynamics. Sixty-five healthy and gender-matched individuals were divided in two groups according to their age: 20y/o and 50y/o. Applanation tonometry was performed using the Sphygmocor device. Central pressures and pulse wave analysis indices were computed. Central systolic (120±3 vs. 98±2 mm Hg) and pulse pressures (43±3 vs. 29±1 mm Hg) as well as the augmentation index (AIx75) (23±3 vs. 6±2%) were significantly higher in the 50y/o group (p<0.01). These parameters are relevant markers of arterial stiffness and evidenced the development of central arterial morphological and functional alterations in the older subjects. The time-tension index (TTI) computed from the systolic pressure area was significantly higher in the 50y/o subjects as compared to the 20y/o group (2378±66 vs. 1954±73 mmHg×s, p<0.01). Moreover, we have shown the presence of significant correlation between TTI and AIx75 (p<0.01) in both age groups. This finding confirmed the contribution of arterial stiffness for the impaired vascular-ventricular coupling. In conclusion, applanation tonometry might be utilized for non-invasive evaluation of the left ventricular load, which is an important parameter of cardiovascular risk.
Polina P. Vasileva, Angel D. Yordanov, Valentina I. Mazneykova, Adelaida L. Ruseva and Dobromir D. Dimitrov
Preeclampsia (PE) is characterized by hypertension and proteinuria after the 20th gestational week (GW). It is a significant cause of maternal and fetal perinatal morbidity and mortality during pregnancy. There is increasing evidence suggesting that PE is due to an impaired balance between maternal placental angiogenic and antiangiogenic factors that harm maternal vascular endothelium. The study aimed to assess the clinical and financial aspects of introducing into practice the soluble fms-like tyrosine kinase (sFlt-1) to placental growth factor (PlGF) ratio test to improve the management of preeclampsia and adverse pregnancy outcome, intrauterine growth retardation, iatrogenic prematurity, and placental abruption.
We report a case study in which we used the sFlt-1/PlGF ratio in the management of a high-risk pregnancy. Unnecessary hospitalization was avoided, and the patient was managed appropriately.