In the working and outside environment a single factor is never found by itself, rather there are always a number of factors the effects of which can be combined, multiplied and thus adversely affect the human body. Evaluating and assessing health risks at work due to exposure to harmful work factors and the working environment is a challenging and long-term process. Limit values are defined for the categorization of types of work in such a way that it is not foreseeable that, according to current scientific knowledge, they will be detrimental to the health of employees. However, these limit values are set for each factor alone and do not take into account the effect of the combined action of individual factors on the human body. The research aimed at assessing the combined effects of risk factors on human health. The experimental proposal of the assessment focuses on the workplace featuring metalworking machinery and technological equipment. The author paid a significant attention to the risk assessment process and synergistic effects of factors.