Current treatment and prevention of chronic rhinitis (CR) and chronic tonsillitis (CT) highlights the need for clinical trials in the respective laboratory model, of better options, including new medicaments. Therefore, to understand CR and CT via the laboratory model, the chronic pro-inflammatory process was simulated in laboratory animals (“Chinchilla” rabbits) using the reference Staphylococcus aureus strain 209P (ATCC 6538-P). Initial sensitizing of the laboratory animals with the inactivated causative agent and subsequently infecting the required area with the reference-strain made it possible to work out a reproducible model of both chronic rhinitis and chronic tonsillitis. Adequacy of CR and CT development was confirmed by the results of microbiological and pathomorphological investigations. The proposed laboratory model can be used to solve theoretical and practical medical current issues, as well as pharmacological topical problems.