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Open access

Katarzyna Wasilewska and Katarzyna Winnicka

Abstract

In recent years, there has been a tendency toward creating innovative, easy to use and patient-friendly drug delivery systems suitable for every consumer profile, which would ensure safety, stability and acceptability of a drug. One of the relatively novel and promising approaches is the manufacture of orodispersible films (ODFs), which is an upcoming area of interest in drug delivery. They are defined as polymer thin films that disintegrate in the oral cavity within seconds, without drinking water or chewing, and eliminate the risk of choking. Gaining special usefulness in therapies of children and the elderly, ODFs seem to fill the gap in the range of preparations available for these groups of patients. As no detailed monography of ODFs including testing methods and uniform requirements has been presented in any of the pharmacopoeias to date, the aim of this article is to give an overview of the applied testing methods, their modifications and innovative approaches related to ODF quality assessment.

Open access

Zeqir Hashani, Qenan Maxhuni, Rrahman Ferizi, Almir Abdurrahmani and Xhavit Mala

Abstract

Flora of the southern part of Kosovo has previously been studied in a limited way due to the difficult terrain and the fact that up to the 1990s it was a military area. In this paper we report Galanthus elwesii Hook for the first time from Kosovo. This species is found in different habitats, mainly in siliceous substrate or wet meadows of the Dragash Municipality, South Kosovo. This species was collected in the Vraça Mountains, near Restelica, (part of National Park ‘Sharri’) on the road leading to the border with Macedonia. The study area consists of territories belonging to the phytogeographic system Skardon-Pindik (Sharri-Pindi) and includes the mountain ranges of Sharri. This research comprises the presence, description, spread and mapping of the species.

Open access

Jun Wang, Yifan Wu, Jueyi Sui and Bryan Karney

Abstract

Ice jams in rivers often arise from the movement of frazil ice as cover-load under ice cover, a process which is conceptually similar to the movement of sediment as bed-load along a river bed. The formation and movement of an ice-accumulation wave is one facet of a larger class of cover-load movements. The movement of an ice-accumulation wave obviously plays a crucial role in the overall process of ice accumulation. In the present study, experiments under different flow and ice conditions help reveal the mechanics of formation and evolution of ice-accumulation waves. In particular, suitable criteria for formation of an ice-accumulation wave are investigated along with the resulting speed of wave propagation. The transport capacity of frazil ice under waved accumulation is modeled by comparing those of experiments collected in laboratories, and the resulting equation is shown to be in good agreement with measured experimental results.

Open access

Mahsa Jahadi, Hossein Afzalimehr and Paweł M. Rowinski

Abstract

Investigation of the interactions between submerged vegetation patch and flow structure is of crucial importance for river engineering. Most of hydraulic models have been presented for fully developed flows over uniform vegetation in the laboratory conditions; however, the mentioned interactions are complex in river flows where the flow is not developed along small patch. This reveals a gap between developed and non-developed flow along the vegetation patch. This study was conducted in a gravel-bed river in the central Iran. The results reveal that the flow structure in evolving flow (non-developed flow) along the patch resembles that in shallow mixing layer. Accordingly, a shallow mixing layer model and modified equations are combined to quantify evolving area along the patch. The evolving shallow mixing layer equations for the flow along a non-uniform vegetation patch reach a reasonable agreement with field data. However, the spreading coefficient of this model less than one was reported in literature, 0.06 and 0.12. In addition, the flow immediately downstream the vegetation patch behaves similar to a jet and is parameterized by two conventional models, conventional logarithmic law and mixing layer theory. These models present a reasonable agreement with the measured velocity profiles immediately downstream the patch.

Open access

Pavel Vlasák, Zdeněk Chára, Václav Matoušek, Jiří Konfršt and Mikoláš Kesely

Abstract

For the safe and economical design and operation of freight pipelines it is necessary to know slurry flow behaviour in inclined pipe sections, which often form significant part of pipelines transporting solids. Fine-grained settling slurry was investigated on an experimental pipe loop of inner diameter D = 100 mm with the horizontal and inclined pipe sections for pipe slopes ranging from −45° to +45°. The slurry consisted of water and glass beads with a narrow particle size distribution and mean diameter d50 = 180 µm. The effect of pipe inclination, mean transport volumetric concentration, and slurry velocity on flow behaviour, pressure drops, deposition limit velocity, and concentration distribution was studied. The study revealed a stratified flow pattern of the studied slurry in inclined pipe sections. Frictional pressure drops in the ascending pipe were higher than that in the descending pipe, the difference decreased with increasing velocity and inclination. For inclination less than about 25° the effect of pipe inclinations on deposition limit velocity and local concentration distribution was not significant. For descending pipe section with inclinations over −25° no bed deposit was observed.

Open access

Snežana Vuksanović, Nada Bubanja and Christian Berg

Abstract

During floristic research of acidic bogs, calcareous fens and seasonally flooded (periodically inundated) grassy places in beech forests in Semolj region, Eleocharis carniolica W. D. J. Koch was found, which was the first record of that species in vascular plant flora of Montenegro. In surrounding countries, this species was recorded in Bosnia and Herzegovina, Croatia, Slovenia and Albania. This paper provides description of sites, habitat and ecology of Eleocharis carniolica W. D. J. Koch in Montenegro.

Open access

Nihal Kuzu and Ekrem Cicek

Abstract

As radiation science and technology advances, nuclear medicine applications are increasing worldwide which necessitate the understanding of biological implications of such practices. Ionizing radiation has been shown to cause degraded matrix and reduced proteoglycan synthesis in cartilage, and the late consequences of which may include degenerative arthritis or arthropathy. Although degenerative effects of the ionizing radiation on cartilage tissue have been demonstrated, the effects on the mechanical properties of articular cartilage are largely unknown. The radiopharmaceuticals, technetium-99m and technetium-99m sestamibi, were utilized on bovine articular cartilage to investigate these effects. We used two different mechanical tests to determine the mechanical properties of articular cartilage. Dynamic and static mechanical tests were applied to calculate compressive modulus for articular cartilage. We observed clearly higher control modulus values than that of experimental groups which account for lesser stiffness in the exposed cartilage. In conclusion, compressive moduli of bovine articular cartilage were found to decrease after radiopharmaceutical exposure, after both instantaneous and equilibrium mechanical experiments.

Open access

Ewa Możdżer, Krystyna Cybulska, Teresa Krzyśko-Łupicka and Edward Meller

Abstract

Therefore the carried out study aimed at determination of the effect of high-calcium brown coal ash and compost being produced from municipal sewage sludge on the content and bioaccumulation of heavy metals in potato tubers, wheat grains and rapeseeds during a three-year period. Rapeseeds contained most Cd whereas wheat rains less. Potato tubers, wheat grains and rapeseeds contained more Mn, Ni and Zn in the fertilization objects with municipal sewage sludge with or without coal ash and compared to those where calcium carbonate or coal ash had been introduced into the soil at a dose corresponding to 1.5 Mg CaO · ha−1 at the beginning of this study. Differences in the Mn, Ni and Zn contents in test plants between the fertilization objects with sewage sludge of with and without addition of ash were not significant.

Open access

Špela Zupančič

Abstract

Core-shell nanofibers have grown in popularity over the last decade owing to their special features and their many applications in biomedicine. They can be produced by electrospinning of immiscible polymer blends or emulsions through a single nozzle or by electrospinning using a coaxial nozzle. Several of the electrospinning parameters allow great versatility for the compositions and diameters of core-shell nanofibers to be produced. Morphology of core-shell nanofibers can be investigated using transmission electron microscopy and, in some cases, scanning electron microscopy. Several studies have shown that core-shell nanofibers have some advantages over monolithic nanofibers, such as better drug, protein, gene or probiotic incorporation into the nanofibers, greater control over drug release, and maintenance of protein structure and activity during electrospinning. We herein review the production and characterization of core-shell nanofibers, the critical parameters that affect their development, and their advantages as delivery systems.

Open access

Fatemeh Afrasiabi, Habib Khodaverdiloo, Farrokh Asadzadeh and Martinus Th. van Genuchten

Abstract

Complete descriptions of the particle-size distribution (PSD) curve should provide more information about various soil properties as opposed to only the textural composition (sand, silt and clay (SSC) fractions). We evaluated the performance of 19 models describing PSD data of soils using a range of efficiency criteria. While different criteria produced different rankings of the models, six of the 19 models consistently performed the best. Mean errors of the six models were found to depend on the particle diameter, with larger error percentages occurring in the smaller size range. Neither SSC nor the geometric mean diameter and its standard deviation correlated significantly with the saturated hydraulic conductivity (Kfs); however, the parameters of several PSD models showed significant correlation with Kfs. Porosity, mean weight diameter of the aggregates, and bulk density also showed significant correlations with PSD model parameters. Results of this study are promising for developing more accurate pedotransfer functions.