Cell Research Experiment In Microgravity (CRExIM) was launched aboard Blue Origin’s New Shepard suborbital vehicle on Tuesday, December 12, 2017, from the West Texas Launch Site in Van Horn, Texas. One of the aims of this science experiment was to assess the effects of microgravity on murine T-cells during suborbital flight. These cells were placed in a NanoLab with a data logger that sensed the acceleration, temperature, and relative humidity during preflight, flight, and postflight operations. Some discrepancies in sensor measurement were noticed, and these errors were attributed partly to the difference in sampling rates and partly to the different locations of the sensors, which made it difficult to obtain highly accurate measurements of the accelerations and to correlate both sets of data. This paper discusses the setbacks and lessons learned, which made our team find new alternatives while meeting all milestones as mandated by NanoRacks and Blue Origin. This manuscript highlights these alternatives that led to the success of the mission and gives recommendations that will enable customers to alleviate some of these challenges in future flights.