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Open access

Irene Rasanu

Abstract

Parkinson’s disease is defined nowadays as a neurodegenerative disease with prominent motor symptoms accompanied by a wide range of comorbidities, some of them, like type 2 diabetes mellitus, probably implicated in the pathogenesis and progression of the disease. In order to achieve this article, which aimed to realize an up to date synthesis of published dedicated papers, a PubMed search was performed; it revealed increasing evidence that these two morbid conditions share many pathogenic pathways and current studies are trying to finally transform the accumulated knowledge into curative therapy or effective prevention for these frequent and complex diseases.

Open access

Adela-Gabriela Firănescu and Maria Moța

Abstract

Tuberculosis (TB) and diabetes mellitus (DM) are two chronic diseases with major impact on worldwide morbidity and mortality. DM significantly increases the risk of death, therapeutic failure and relapse of TB, requiring a much more careful monitoring of these patients. In this article we present the case of a patient with type 2 DM in the stage of major chronic complications, with numerous risk factors for TB and atypical symptomatology, pulmonary X-ray showing active TB lesions. The patient did not follow the diabetologist's recommendations, discontinuing the antidiabetic treatment on his own initiative. The glycemic imbalance and chronic alcoholism caused the failure of the anti TB therapy.

Open access

Simona Popoviciu, Anca Alionescu and Irma Sisic

Abstract

Background and aims: The aim of this study was to assess the prevalence and evaluate the impact on several treatment and quality of life parameters of hypoglycemia in type 2 diabetes mellitus patients treated with sulfonylureas (SU) in Romania. Secondary objective was to determine the proportion of patients attaining haemoglobin A1c (HbA1c) target of <7%.

Material and method: This was a multi-center, observational study using retrospective clinical chart and laboratory parameters review, and a cross-sectional survey in Romania. The sample in this study consisted of 385 patients. Socio-demographic and clinical variables were compared between patients with inadequate and adequate control.

Results: The mean age of all enrolled subjects was 65.37 (33-87) years. The average BMI was 30.44 kg/m2. Mean diabetes duration was 7.76 (6 months -32) years with the mean age of diabetes at diagnosis of 57.75 (31-85) years. HbA1c was recorded for 238 subjects with mean value of 7.12 (4.8-10.97) %.

Conclusions: The prevalence of hypoglycaemia in SU treated patients was 42.2%. Highest prevalence was in the 50-60 age category, at 49.2% and lowest among the eldest subjects (>70 years), at 38.6%. Prevalence of patients at the goal of HbA1c<7% was 50.8 %. Patients with adequate glycaemic control had more acceptable BMI than those with inadequate glycaemic control. In patients not achieving a goal of HbA1c < 7%, higher level of plasma glucose and total cholesterol was determined compared to those with adequate glycaemic control. There were no significant differences in the HDL-C, triglycerides or albumin:creatinine ratios in patients with both adequate and inadequate glycaemic control.

Open access

Farid Berroukeche, Nassima Mokhtari-Soulimane, Asmahan Imessaoudene, Ahmed Sabri Cherrak, Pascale Ronot, Anne Boos, Amina Belhandouz, Hafida Merzouk and Mourad Elhabiri

Abstract

Background and aims: Quercetin, is a polyphenolic antioxidant compound. It is able to form complex with metal ions such as iron and exerts a broad range of biological activities like improving metabolic disorders. This research aims at investigating the effect of oral supplementation of iron (2.5mg Fe/Kg/day) and its complex form (molar ratio 1:5; 2.5mg/25mg/Kg/day) with quercetin (25mg/Kg/day) on lipid metabolism, oxidant status and trace elements contents in organs of Wistar diabetic rats (45 mg/kg/rat.ip of streptozotocin) during eight weeks of experimentation.

Material and method: To achieve this, liver and adipose tissue enzymes activities, NO, O2−•, TBARs, carbonyl protein levels in plasma were analysed. Metals (Cu, Fe, Mg, Zn) analysis of organs were determined by inductively coupled plasma atomic emission spectroscopy.

Results: Iron supplemented alone induced a noticeable disorder in lipid, lipoprotein, lipases and oxidant status. Yet, it caused an imbalance in the redistribution of metals in the organs of diabetic and non diabetic rats. Iron-quercetin complex was shown as less harmful and more beneficial than iron supplemented alone.

Conclusions: This complex could reverse oxidative stress and iron deficiency mostly caused by the diabetic disease but at the same time it induces an imbalance in redistribution of other essential metals.

Open access

Delia Monica Glodean, Diana Miclea, Gabriela Zaharie, Janina Mihaela Mihăilă and Amorin Remus Popa

Abstract

Background and aims: The purpose of this study was to evaluate the frequency of demographic and clinical risk factors for fetal macrosomia, maternal pregestational, gestational and intra partum pathology associated with macrosomia, and to investigate the dynamic of these parameters in a decade.

Material and method: We conducted two studies, a case-control study of 261 mothers who delivered macrosomic babies and 241 mothers who delivered normal weight babies in 2016, and then we compared the parameters obtained from the study group of 261women who delivered in 2016 macrosomic babies with those of a study group of 220 women who delivered macrosomic babies in 2006 at Gynecology I County Hospital of Cluj-Napoca. The data was stored and analyzed using Microsoft Excel.

Results and conclusions: Overweight before pregnancy, the excessive weight gain during pregnancy, and the delivery of a macrosomic baby increase the risk to deliver in the future a macrosomic baby. Mothers who delivered macrosomic babies had a higher incidence of thyroid gland pathology (hypofunction) and gestational diabetes than those who delivered normal weight babies.

Open access

Florin Mihălţan and Anca Hâncu

Open access

Paria Dehesh, Tania Dehesh and Mohammad Hossein Gozashti

Abstract

Background and aims: Diabetes mellitus (DM) patients have a lower quality of life. This study aimed to examine the direct and indirect effect of eight domains score of the SF-36 questionnaire on two main factors, i.e., overall physical health (GH_M) and overall mental health (MH_M), in DM patients. To the best of our knowledge, this issue has been rarely studied so far.

Material and method: A total of 1037 DM patients filled out the Persian version of the SF-36 questionnaire. The path analysis was used in this study.

Results: In this research, only social functioning (SF) domain has significantly lower the men compared to women (P=0.06). Physical functioning (PF), bodily pain (BP), general health (GH) and vitality (VT) have a negative significant direct effect on the GH_M factor. GH domain also has a positive indirect and total effect on MH_M factor, and other domains have no significant total effect on MH_M factor.

Conclusion: It is better that physicians, focus on regulating physical activity and reducing body pain in diabetes patients, which have the most direct impact on HRQoL, to achieve a more effective outcome in improving quality of life in this patient.

Open access

Anca Ștefania Mesaroș, Roxana Oancea, Alexandru Grecu and Aranka Ilea

Abstract

Background and aims: Diabetes has a high prevalence in both pediatric as well as adult populations in present times. Dental caries represents also a very serious problem form the health point of view in all population. Our study wishes to emphasize the relation between diabetes and oral health status in pediatric patients, also inquiring upon their awareness of the link between the two.

Material and method: 15 diabetic patients were compared with 15 non-diabetic matching patients.

Results: The study concluded in showing the importance of a correct oral hygiene in all patients with emphasize in cases of diabetic patients.

Conclusions: Awareness of the link between diabetes and oral health status should be promoted not only by dentists but also by their general medicine practitioner as well as diabetes specialists and nutrition specialist.

Open access

Paula Dejeu, Viorel Dejeu, Dănuț Dejeu and Bembea Marius

Abstract

Background and aims: Overweight and obese individuals are prone to an insulin resistance status assessed in the present study by the HOMA index ("Homeostasis model assessment"). This prospective study assessed the body mass index (BMI) and the insulin resistance status (HOMA index) in obese patients after bariatric surgery (gastric sleeve, gastric by-pass).

Material and Methods: The study included 48 patients who were assessed before the bariatric surgery and at 6 months thereafter. The assessment included the body mass index (BMI) and the HOMA index before meal.

Results: There was a significant positive correlation between BMI and HOMA index, mostly between weight loss and improvement in insulin resistance status (rho = 0.308, p = 0.0335).

Conclusions: BMI decreases significantly after bariatric surgery, which correlates positively with an improvement in insulin resistance status.

Open access

Costela Lăcrimioara Șerban, Denis Mihai Șerban, Ștefania Ioana Butica and Diana Lungeanu

Abstract

Since their publication in 1965, the Bradford Hill criteria for causality have been largely used as a framework for causal inference in epidemiology. We aim at employing this classical approach to shed new light onto the web of causation of childhood obesity. Although the fundamental cause of obesity is the long-term imbalance between energetic need and intake, this medical condition is multifactorial in its origin, influenced by genetic, behavioral, socioeconomic, and environmental factors. This imbalance leads to accumulation of excessive adipose tissue. Observational studies tend to mostly quantify association between dietary factors and accumulation of adipose tissue. On the other hand, multivariate analysis proved some of these associations to be spurious, therefore prospective trials are needed to demonstrate causality. Short term experimental studies have been conducted to identify unique dietary pattern changes on specific outcomes, but long term, community-based studies would offer more comprehensive answers on dietary pattern effects. We conducted a literature review on PubMed, Scopus, Web of Science, and Google Scholar. From a total of 323 papers identified at first stage, we further discuss the applicability of Bradford Hill criteria for 31 articles, by examples of dietary patterns and accumulation of excess body fat as exposure-response associations. We also put forward and analyzed the evidence prospective studies would bring, as foundation for future interventions.