An Experimental Study on the Mechanisms of Ge Hua Jie Cheng Decoction for Rats with Alcoholic Liver Injuries

Open access


Objective: To explore the effects and underlying mechanisms of Ge Hua Jie Cheng Decoction on rats with alcoholic liver injuries.

Methods: 60 Wistar rats were randomly assigned to six groups: normal group, model group, Yi Gan Ling group, and Ge Hua Jie Cheng Decoction groups in low, middle and high concentrations, 10 rats in each group. Except for the normal group, rats in other groups were administered white wine for eight weeks to establish the liver injury model. During the modeling, the Yi Gan Ling/Ge Hua Jie Cheng Decoction were administered intragastrically to the rats. So the histopathological changes were observed after eight weeks, meanwhile the serum γ- glutamyl endopeptidase (GGT), Glutathione (GSH) and aspartate aminotransferase mitochondrial isoenzyme (m-AST) were assayed by automatic biochemical analyzer.

Results: under the light microscope, the groups of high and middle dosages of Ge Hua Jie Cheng Decoction , especially the high one, had apparent improvement of inflammatory infiltration in liver tissues. Compared with the normal group, the serum GGT and m-AST levels had elevated (P<0.01), whereas the serum GSH level decreased (P<0.01); compared with model group, the high and middle dosages of Ge Hua Jie Cheng Decoction groups had decreased serum GGT and m-AST (P<0.01 or P<0.05), as well as increased serum GSH level (P<0.01).

Conclusion: Ge Hua Jie Cheng Decoction has a protective effect for liver injuries induced by alcohol, and this effect is dose-dependent. The high dosage showed stronger protection effect, which might be related to the increased serum GSH and decreased serum GGT and m-AST.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. You-Ming LI. Epidemiology and history of ALD. Chinese Journal of Hepatology 201018(3):171-172.

  • 2. Wan-Zhi YANG. Research advancement of pathogenesis of liver diseases. Acta Universitatis Medicinalis Anhui 201247(1): 124-126.

  • 3. Wei ZHANG Ru-Tao HONG Tu-Lei TIAN. Establishment of rat ALD models. Anhui Medical and Pharmaceutical Journal 2012 16 (7):885-887.

  • 4. Hua Jing. TCM etiology and pathogenesis of ALD. Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases 2012,22(4):249-250.

  • 5. Chun-Hua WANG Zhi-Lan YANG Shu-Yun DUAN et al. Clinical Investigation on Intervened Course of Acute Sever Alcoholism with Infusion of Jiaweighuajiechentang into Stomach.

  • 6 Guo-Hui AN. Modified Ge Hua Jie Cheng Decoction for 46 cases of alcoholic liver disease. Chinese Medicine Modern Distance Education of China 20108(9):23-24.

  • 7 Zhong-Cheng CHEN Wen-Si CHEN. Clinical significance of GGT AFP CA199 in patients with liver diseases. Clinical Medical Engineering 201219(11):1903-1906.

  • 8 Zong-Xiao DU Fu-Rong LI Wen-Hua PIAO et al. Cllinical significance of serum AST in alcoholic liver disease. Laboratory Medicine201227(9):732-735.

  • 9 Ping QIU Xiang LI De-Song KONG et al. New advaancement of research on alcoholic liver disease. Chinese Pharmacological Bulletin 201430(2):160-163.

  • 10 Hong-Qiu YE Du-Xin QING. Research progress on immune mechanisms of alcoholic liver disease. International Journal of Digestive Diseases 2011,31(5):283-285.

  • 11 Ping-Ge YUAN Da-Zhi ZHANG. Effect mechanism and clinical utilization of Glutathione. Drug Evaluation 20063(5): 385-388.

  • 12 Xing-Xing SONG Jin-Ling SU Ye-Dong BI et al. Experimental study on the effects of Wu Tian Bao Gan Ye on tissue SOD MDA and GSH-PX in rats with alcoholic liver disease. Jilin Journal of Traditional Chinese Medicine 201131(5):477-479.

Journal information
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 417 218 6
PDF Downloads 131 88 2