Oleić Acid – Health Benefits and Status in Plasma Phospholipids in the Serbian Population

Open access

Abstract

Oleic acid has many beneficial effects on human health. One of the main dietary sources of oleic acid is olive oil. Non-Mediterranean European countries, including Serbia, have low habitual olive oil consumption, but other vegetable oils also contain different amounts of oleic acid. In infants and young children milk is the most important source of fatty acids, including oleic acid. Furthermore, fatty acid composition of plasma phospholipids reflects dietary intake and fatty acid metabolism. In patients with serious chronic diseases fatty acid status is altered independently on the intake. Here we reviewed status of oleic acid in healthy persons as well as in patients with different chronic diseases in Serbia.

Abstract

Oleic acid has many beneficial effects on human health. One of the main dietary sources of oleic acid is olive oil. Non-Mediterranean European countries, including Serbia, have low habitual olive oil consumption, but other vegetable oils also contain different amounts of oleic acid. In infants and young children milk is the most important source of fatty acids, including oleic acid. Furthermore, fatty acid composition of plasma phospholipids reflects dietary intake and fatty acid metabolism. In patients with serious chronic diseases fatty acid status is altered independently on the intake. Here we reviewed status of oleic acid in healthy persons as well as in patients with different chronic diseases in Serbia.

References

  • 1. Perez-Martinez P, Garcia-Rios A, Delgado-Lista J, Perez-Jimenez F, Lopez-Miranda J: Mediterranean diet rich in olive oil and obesity, metabolic syndrome and diabetes mellitus. Curr Pharm Des 2011; 17(8):769-77.

  • 2. Psaltopoulou T, Naska A, Orfanos P, Trichopoulos D, Mountokalakis T, Trichopoulou A: Olive oil, the Mediterranean diet, and arterial blood pressure: the Greek European Prospective Investigation into Cancer and Nutrition (EPIC) study. Am J Clin Nutr 2004; 80(4):1012-18.

  • 3. Samieri C, Feart C, Proust-Lima C, Peuchant E, Tzourio C, Stapf C, Berr C, Barberger-Gateau P: Olive oil consumption, plasma oleic acid, and stroke incidence: The Three-City Study. Neurology 2011.

  • 4. Visioli F, Galli C: Biological properties of olive oil phytochemicals. Crit Rev Food Sci Nutr 2002; 42(3):209-21.

  • 5. Miraliakbari H, Shahidi F: Oxidative stability of tree nut oils. J Agric Food Chem 2008; 56(12):4751-9.

  • 6. Araujo de Vizcarrondo C CdPF, Martin E: Fatty acid composition of beef, pork, and poultry fresh cuts, and some of their processed products. Arch Latinoam Nutr 1998; 48(3):354-8.

  • 7. Sahin N, Akoh CC, Karaali A: Human milk fat substitutes containing omega-3 fatty acids. J Agric Food Chem 2006; 54(10):3717-22.

  • 8. Rioux FM, Innis SM: Oleic acid (18:1) in plasma, liver and brain myelin lipid of piglets fed from birth with formulas differing in 18:1 content. J Nutr 1992; 122(7):1521-8.

  • 9. Fidler N, Koletzko B: The fatty acid composition of human colostrum. Eur J Nutr 2000; 39(1):31-7.

  • 10. Wu TC, Lau BH, Chen PH, Wu LT, Tang RB: Fatty acid composition of Taiwanese human milk. J Chin Med Assoc 2010; 73(11):581-8.

  • 11. Ribeiro M, Balcao V, Guimaraes H, Rocha G, Moutinho C, Matos C, Almeida C, Casal S, Guerra A: Fatty acid profile of human milk of Portuguese lactating women: prospective study from the 1st to the 16th week of lactation. Ann Nutr Metab 2008; 53(1):50-6.

  • 12. Yuhas R, Pramuk K, Lien EL: Human milk fatty acid composition from nine countries varies most in DHA. Lipids 2006; 41(9):851-8.

  • 13. Bartl K, Gomez CA, Garcia M, Aufdermauer T, Kreuzer M, Hess HD, Wettstein HR: Milk fatty acid profile of Peruvian Criollo and Brown Swiss cows in response to different diet qualities fed at low and high altitude. Arch Anim Nutr 2008; 62(6):468-84.

  • 14. Tepsic J, Vucic V, Arsic A, Blazencic-Mladenovic V, Mazic S, Glibetic M: Plasma and erythrocyte phospholipid fatty acid profile in professional basketball and football players. Eur J Appl Physiol 2009; 107(3):359-65.

  • 15. Katan MB, Deslypere JP, van Birgelen AP, Penders M, Zegwaard M: Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study. J Lipid Res 1997; 38(10):2012-22.

  • 16. Popović T, Borozan, S., Arsić, A., Debeljak-Martačić, J., Vučić, V., de Luka, S., Milovanović, I., Trbović, A., Glibetić M: Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats Croatica Chemica Acta 2011; 84(1):73-9.

  • 17. Arsic A, Vucic V, Prekajski N, Tepsic J, Ristic-Medic D, Velickovic V Glibetic M. Different fatty acid composition of serum phospholipids of small and appropriate for gestational age preterm infants and of milk from their mothers. Hippokratia 2012; 16(3): 230-35.

  • 18. Cvetkovic Z, Vucic V, Cvetkovic B, Petrovic M, Ristic-Medic D, Tepsic J, Glibetic M: Abnormal fatty acid distribution of the serum phospholipids of patients with non-Hodgkin lymphoma. Ann Hematol 2010; 89(8): 775-82.

  • 19. Tepsic J, Vucic V, Arsic A, Mazic S, Djelic M, Glibetic M. Unfavourable plasma and erythrocyte phospholipid fatty acid profile in elite amateur boxers. Eur J Sport Sci 2013; 13:414-21.

  • 20. Arsic A, Vucic V, Tepsic J, Mazic S, Djelic M, Glibetic M. Altered plasma and erythrocyte phospholipid fatty acid profile in elite female water polo and football players. Appl Physiol Nutr Metab 2012; 37(1): 40-7.

  • 21. Popovic T, Ranic M, Bulajic P, Milicevic M, Arsic A, Vucic V, Glibetic M. Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study. J Clin Biochem Nutr 2009; 45(3): 370-5.

  • 22. Ristić V, Tepsić V, Ristić-Medie D, Perunicić G, Rasić Z, Postić M, Arsić A, Blazencić-Mladenović V, Ristić G. Plasma and erythrocyte phospholipid fatty acids composition in Serbian hemodialyzed patients. Ren Fail 2006; 28(3): 211-6.

  • 23. Petrovic S, Arsic A, Glibetic M, Cikiriz N, Jakovljevic V, Vucic V. The effects of polyphenol-rich chokeberry juice on fatty acid profiles and lipid peroxidation of active handball players: results from a randomized, double-blind, placebo-controlled study. Can J Physiol Pharmacol 2016; 94(10): 1058-63.

  • 24. Ristic-Medic D, Suzic S, Vucic V, Takic M, Tepsic J, Glibetic M: Serum and erythrocyte membrane phospholipids fatty acid composition in hyperlipidemia: effects of dietary intervention and combined diet and fibrate therapy. Gen Physiol Biophys 2009; 28 Spec No:190-9.

  • 25. Ristić Medić D, Ristić V, Arsić A, Postić M, Ristić G, Blazencić Mladenović V, Tepsić J. Effects of soybean DLeciVita product on serum lipids and fatty acid composition in type 2 diabetic patients with hyperlipidemia. Nutr Metab Cardiovasc Dis 2006; 16(6): 395-404.

  • 26. Ristić-Medić D, Takić M, Vučić V, Kandić D, Kostić N, Glibetić M. Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study. J Clin Biochem Nutr 2013; 53(1): 49-54.

  • 27. Veselinovic M, Vasiljevic D, Vucic V, Arsic A, Petrovic S, Tomic-Lucic A, Savic M, Zivanovic S, Stojic V, Jakovljevic V. Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis. Nutrients 2017; 9(4). pii: E325. doi:

  • 28. Pauwels EK: The protective effect of the Mediterranean diet: focus on cancer and cardiovascular risk. Med Princ Pract 2011; 20(2):103-11.

  • 29. Kris-Etherton PM, Pearson TA, Wan Y, Hargrove RL, Moriarty K, Fishell V, Etherton TD: High-monounsaturated fatty acid diets lower both plasma cholesterol and triacylglycerol concentrations. Am J Clin Nutr 1999; 70(6):1009-15.

  • 30. Lopez-Miranda J, Perez-Jimenez F, Ros E, De Caterina R, Badimon L, Covas MI, Escrich E, Ordovas JM, Soriguer F, Abia R et al: Olive oil and health: summary of the II international conference on olive oil and health consensus report, Jaen and Cordoba (Spain) 2008. Nutr Metab Cardiovasc Dis 2010; 20(4):284-94.

  • 31. Granados N, Amengual J, Ribot J, Palou A, Bonet ML: Distinct effects of oleic acid and its trans-isomer elaidic acid on the expression of myokines and adipokines in cell models. Br J Nutr 2011; 105(8):1226-34.

  • 32. Kien CL: Dietary interventions for metabolic syndrome: role of modifying dietary fats. Curr Diab Rep 2009; 9(1):43-50.

  • 33. Lopez-Huertas E: Health effects of oleic acid and long chain omega-3 fatty acids (EPA and DHA) enriched milks. A review of intervention studies. Pharmacol Res 2010; 61(3):200-7.

  • 34. Mensink RP, Zock PL, Kester AD, Katan MB: Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 2003; 77(5):1146-55.

  • 35. Pedersen A, Baumstark MW, Marckmann P, Gylling H, Sandstrom B: An olive oil-rich diet results in higher concentrations of LDL cholesterol and a higher number of LDL subfraction particles than rapeseed oil and sunflower oil diets. J Lipid Res 2000; 41(12):1901-11.

  • 36. Saadatian-Elahi M, Slimani N, Chajes V, Jenab M, Goudable J, Biessy C, Ferrari P, Byrnes G, Autier P, Peeters PH et al: Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 2009; 89(1):331-46.

  • 37. Hodge AM, Simpson JA, Gibson RA, Sinclair AJ, Makrides M, O’Dea K, English DR, Giles GG: Plasma phospholipid fatty acid composition as a biomarker of habitual dietary fat intake in an ethnically diverse cohort. Nutr Metab Cardiovasc Dis 2007; 17(6):415-26.

  • 38. Binukumar B, Mathew A: Dietary fat and risk of breast cancer. World J Surg Oncol 2005; 3:45.

  • 39. Bartsch H, Nair J, Owen RW: Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers. Carcinogenesis 1999; 20(12):2209-18.

  • 40. Escrich E, Moral R, Grau L, Costa I, Solanas M: Molecular mechanisms of the effects of olive oil and other dietary lipids on cancer. Mol Nutr Food Res 2007; 51(10):1279-92.

  • 41. Menendez JA, Lupu R: Mediterranean dietary traditions for the molecular treatment of human cancer: anti-oncogenic actions of the main olive oil’s monounsaturated fatty acid oleic acid (18:1n-9). Curr Pharm Biotechnol 2006; 7(6):495-502.

  • 42. Menendez JA, Papadimitropoulou A, Vellon L, Lupu R: A genomic explanation connecting “Mediterranean diet”, olive oil and cancer: oleic acid, the main monounsaturated fatty acid of olive oil, induces formation of inhibitory “PEA3 transcription factor-PEA3 DNA binding site” complexes at the Her-2/neu (erbB-2) oncogene promoter in breast, ovarian and stomach cancer cells. Eur J Cancer 2006; 42(15):2425-32.

  • 43. Stojanović A, Zeković M, Rašić-Milutinović Z, Ristić- Medić D, Pokimica, Debeljak-Martačić J, Vučić Vesna: Dietary intake in newly diagnosed lung cancer patients. Srp arh celok lek, 2017; doi.org/10.2298/SARH170301115S

  • 44. Vucic V, Tepsic J, Arsic A, Popovic T, Debeljak-Martacic J, Glibetic M. Fatty Acid Content of Vegetable Oils and Assessment of Their Consumption in Serbia. Acta Aliment 2012; 41:343-50.

  • 45. Haug A, Hostmark AT, Harstad OM: Bovine milk in human nutrition--a review. Lipids Health Dis 2007; 6:25.

  • 46. Lichtenstein AH, Appel LJ, Brands M, Carnethon M, Daniels S, Franch HA, Franklin B, Kris-Etherton P, Harris WS, Howard B et al: Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 2006; 114(1):82-96.

  • 47. Komprda T, Zelenka J, Fajmonova E, Fialova M, Kladroba D: Arachidonic acid and long-chain n-3 polyunsaturated fatty acid contents in meat of selected poultry and fish species in relation to dietary fat sources. J Agric Food Chem 2005; 53(17):6804-12.

  • 48. Collomb M, Sieber R, Butikofer U: CLA isomers in milk fat from cows fed diets with high levels of unsaturated fatty acids. Lipids 2004; 39(4):355-64.

  • 49. Arsić A, Prekajski N, Vučić V, Tepsić J, Popović T, Vrvić M, Glibetić M. Milk in human nutrition: comparison of fatty acid profiles. Acta vet (Beograd) 2009; 59:569-78.

  • 50. Fidler N, Sauerwald T, Pohl A, Demmelmair H, Koletzko B: Docosahexaenoic acid transfer into human milk after dietary supplementation: a randomized clinical trial. J Lipid Res 200; 41(9):1376-83.

  • 51. Jensen RG, Lammi-Keefe CJ, Henderson RA, Bush VJ, Ferris AM: Effect of dietary intake of n-6 and n-3 fatty acids on the fatty acid composition of human milk in North America. J Pediatr 1992; 120(4 Pt 2):S87-92.

1. Perez-Martinez P, Garcia-Rios A, Delgado-Lista J, Perez-Jimenez F, Lopez-Miranda J: Mediterranean diet rich in olive oil and obesity, metabolic syndrome and diabetes mellitus. Curr Pharm Des 2011; 17(8):769-77.

2. Psaltopoulou T, Naska A, Orfanos P, Trichopoulos D, Mountokalakis T, Trichopoulou A: Olive oil, the Mediterranean diet, and arterial blood pressure: the Greek European Prospective Investigation into Cancer and Nutrition (EPIC) study. Am J Clin Nutr 2004; 80(4):1012-18.

3. Samieri C, Feart C, Proust-Lima C, Peuchant E, Tzourio C, Stapf C, Berr C, Barberger-Gateau P: Olive oil consumption, plasma oleic acid, and stroke incidence: The Three-City Study. Neurology 2011.

4. Visioli F, Galli C: Biological properties of olive oil phytochemicals. Crit Rev Food Sci Nutr 2002; 42(3):209-21.

5. Miraliakbari H, Shahidi F: Oxidative stability of tree nut oils. J Agric Food Chem 2008; 56(12):4751-9.

6. Araujo de Vizcarrondo C CdPF, Martin E: Fatty acid composition of beef, pork, and poultry fresh cuts, and some of their processed products. Arch Latinoam Nutr 1998; 48(3):354-8.

7. Sahin N, Akoh CC, Karaali A: Human milk fat substitutes containing omega-3 fatty acids. J Agric Food Chem 2006; 54(10):3717-22.

8. Rioux FM, Innis SM: Oleic acid (18:1) in plasma, liver and brain myelin lipid of piglets fed from birth with formulas differing in 18:1 content. J Nutr 1992; 122(7):1521-8.

9. Fidler N, Koletzko B: The fatty acid composition of human colostrum. Eur J Nutr 2000; 39(1):31-7.

10. Wu TC, Lau BH, Chen PH, Wu LT, Tang RB: Fatty acid composition of Taiwanese human milk. J Chin Med Assoc 2010; 73(11):581-8.

11. Ribeiro M, Balcao V, Guimaraes H, Rocha G, Moutinho C, Matos C, Almeida C, Casal S, Guerra A: Fatty acid profile of human milk of Portuguese lactating women: prospective study from the 1st to the 16th week of lactation. Ann Nutr Metab 2008; 53(1):50-6.

12. Yuhas R, Pramuk K, Lien EL: Human milk fatty acid composition from nine countries varies most in DHA. Lipids 2006; 41(9):851-8.

13. Bartl K, Gomez CA, Garcia M, Aufdermauer T, Kreuzer M, Hess HD, Wettstein HR: Milk fatty acid profile of Peruvian Criollo and Brown Swiss cows in response to different diet qualities fed at low and high altitude. Arch Anim Nutr 2008; 62(6):468-84.

14. Tepsic J, Vucic V, Arsic A, Blazencic-Mladenovic V, Mazic S, Glibetic M: Plasma and erythrocyte phospholipid fatty acid profile in professional basketball and football players. Eur J Appl Physiol 2009; 107(3):359-65.

15. Katan MB, Deslypere JP, van Birgelen AP, Penders M, Zegwaard M: Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study. J Lipid Res 1997; 38(10):2012-22.

16. Popović T, Borozan, S., Arsić, A., Debeljak-Martačić, J., Vučić, V., de Luka, S., Milovanović, I., Trbović, A., Glibetić M: Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats Croatica Chemica Acta 2011; 84(1):73-9.

17. Arsic A, Vucic V, Prekajski N, Tepsic J, Ristic-Medic D, Velickovic V Glibetic M. Different fatty acid composition of serum phospholipids of small and appropriate for gestational age preterm infants and of milk from their mothers. Hippokratia 2012; 16(3): 230-35.

18. Cvetkovic Z, Vucic V, Cvetkovic B, Petrovic M, Ristic-Medic D, Tepsic J, Glibetic M: Abnormal fatty acid distribution of the serum phospholipids of patients with non-Hodgkin lymphoma. Ann Hematol 2010; 89(8): 775-82.

19. Tepsic J, Vucic V, Arsic A, Mazic S, Djelic M, Glibetic M. Unfavourable plasma and erythrocyte phospholipid fatty acid profile in elite amateur boxers. Eur J Sport Sci 2013; 13:414-21.

20. Arsic A, Vucic V, Tepsic J, Mazic S, Djelic M, Glibetic M. Altered plasma and erythrocyte phospholipid fatty acid profile in elite female water polo and football players. Appl Physiol Nutr Metab 2012; 37(1): 40-7.

21. Popovic T, Ranic M, Bulajic P, Milicevic M, Arsic A, Vucic V, Glibetic M. Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study. J Clin Biochem Nutr 2009; 45(3): 370-5.

22. Ristić V, Tepsić V, Ristić-Medie D, Perunicić G, Rasić Z, Postić M, Arsić A, Blazencić-Mladenović V, Ristić G. Plasma and erythrocyte phospholipid fatty acids composition in Serbian hemodialyzed patients. Ren Fail 2006; 28(3): 211-6.

23. Petrovic S, Arsic A, Glibetic M, Cikiriz N, Jakovljevic V, Vucic V. The effects of polyphenol-rich chokeberry juice on fatty acid profiles and lipid peroxidation of active handball players: results from a randomized, double-blind, placebo-controlled study. Can J Physiol Pharmacol 2016; 94(10): 1058-63.

24. Ristic-Medic D, Suzic S, Vucic V, Takic M, Tepsic J, Glibetic M: Serum and erythrocyte membrane phospholipids fatty acid composition in hyperlipidemia: effects of dietary intervention and combined diet and fibrate therapy. Gen Physiol Biophys 2009; 28 Spec No:190-9.

25. Ristić Medić D, Ristić V, Arsić A, Postić M, Ristić G, Blazencić Mladenović V, Tepsić J. Effects of soybean DLeciVita product on serum lipids and fatty acid composition in type 2 diabetic patients with hyperlipidemia. Nutr Metab Cardiovasc Dis 2006; 16(6): 395-404.

26. Ristić-Medić D, Takić M, Vučić V, Kandić D, Kostić N, Glibetić M. Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study. J Clin Biochem Nutr 2013; 53(1): 49-54.

27. Veselinovic M, Vasiljevic D, Vucic V, Arsic A, Petrovic S, Tomic-Lucic A, Savic M, Zivanovic S, Stojic V, Jakovljevic V. Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis. Nutrients 2017; 9(4). pii: E325. doi:

28. Pauwels EK: The protective effect of the Mediterranean diet: focus on cancer and cardiovascular risk. Med Princ Pract 2011; 20(2):103-11.

29. Kris-Etherton PM, Pearson TA, Wan Y, Hargrove RL, Moriarty K, Fishell V, Etherton TD: High-monounsaturated fatty acid diets lower both plasma cholesterol and triacylglycerol concentrations. Am J Clin Nutr 1999; 70(6):1009-15.

30. Lopez-Miranda J, Perez-Jimenez F, Ros E, De Caterina R, Badimon L, Covas MI, Escrich E, Ordovas JM, Soriguer F, Abia R et al: Olive oil and health: summary of the II international conference on olive oil and health consensus report, Jaen and Cordoba (Spain) 2008. Nutr Metab Cardiovasc Dis 2010; 20(4):284-94.

31. Granados N, Amengual J, Ribot J, Palou A, Bonet ML: Distinct effects of oleic acid and its trans-isomer elaidic acid on the expression of myokines and adipokines in cell models. Br J Nutr 2011; 105(8):1226-34.

32. Kien CL: Dietary interventions for metabolic syndrome: role of modifying dietary fats. Curr Diab Rep 2009; 9(1):43-50.

33. Lopez-Huertas E: Health effects of oleic acid and long chain omega-3 fatty acids (EPA and DHA) enriched milks. A review of intervention studies. Pharmacol Res 2010; 61(3):200-7.

34. Mensink RP, Zock PL, Kester AD, Katan MB: Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 2003; 77(5):1146-55.

35. Pedersen A, Baumstark MW, Marckmann P, Gylling H, Sandstrom B: An olive oil-rich diet results in higher concentrations of LDL cholesterol and a higher number of LDL subfraction particles than rapeseed oil and sunflower oil diets. J Lipid Res 2000; 41(12):1901-11.

36. Saadatian-Elahi M, Slimani N, Chajes V, Jenab M, Goudable J, Biessy C, Ferrari P, Byrnes G, Autier P, Peeters PH et al: Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 2009; 89(1):331-46.

37. Hodge AM, Simpson JA, Gibson RA, Sinclair AJ, Makrides M, O’Dea K, English DR, Giles GG: Plasma phospholipid fatty acid composition as a biomarker of habitual dietary fat intake in an ethnically diverse cohort. Nutr Metab Cardiovasc Dis 2007; 17(6):415-26.

38. Binukumar B, Mathew A: Dietary fat and risk of breast cancer. World J Surg Oncol 2005; 3:45.

39. Bartsch H, Nair J, Owen RW: Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers. Carcinogenesis 1999; 20(12):2209-18.

40. Escrich E, Moral R, Grau L, Costa I, Solanas M: Molecular mechanisms of the effects of olive oil and other dietary lipids on cancer. Mol Nutr Food Res 2007; 51(10):1279-92.

41. Menendez JA, Lupu R: Mediterranean dietary traditions for the molecular treatment of human cancer: anti-oncogenic actions of the main olive oil’s monounsaturated fatty acid oleic acid (18:1n-9). Curr Pharm Biotechnol 2006; 7(6):495-502.

42. Menendez JA, Papadimitropoulou A, Vellon L, Lupu R: A genomic explanation connecting “Mediterranean diet”, olive oil and cancer: oleic acid, the main monounsaturated fatty acid of olive oil, induces formation of inhibitory “PEA3 transcription factor-PEA3 DNA binding site” complexes at the Her-2/neu (erbB-2) oncogene promoter in breast, ovarian and stomach cancer cells. Eur J Cancer 2006; 42(15):2425-32.

43. Stojanović A, Zeković M, Rašić-Milutinović Z, Ristić- Medić D, Pokimica, Debeljak-Martačić J, Vučić Vesna: Dietary intake in newly diagnosed lung cancer patients. Srp arh celok lek, 2017; doi.org/10.2298/SARH170301115S

44. Vucic V, Tepsic J, Arsic A, Popovic T, Debeljak-Martacic J, Glibetic M. Fatty Acid Content of Vegetable Oils and Assessment of Their Consumption in Serbia. Acta Aliment 2012; 41:343-50.

45. Haug A, Hostmark AT, Harstad OM: Bovine milk in human nutrition--a review. Lipids Health Dis 2007; 6:25.

46. Lichtenstein AH, Appel LJ, Brands M, Carnethon M, Daniels S, Franch HA, Franklin B, Kris-Etherton P, Harris WS, Howard B et al: Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 2006; 114(1):82-96.

47. Komprda T, Zelenka J, Fajmonova E, Fialova M, Kladroba D: Arachidonic acid and long-chain n-3 polyunsaturated fatty acid contents in meat of selected poultry and fish species in relation to dietary fat sources. J Agric Food Chem 2005; 53(17):6804-12.

48. Collomb M, Sieber R, Butikofer U: CLA isomers in milk fat from cows fed diets with high levels of unsaturated fatty acids. Lipids 2004; 39(4):355-64.

49. Arsić A, Prekajski N, Vučić V, Tepsić J, Popović T, Vrvić M, Glibetić M. Milk in human nutrition: comparison of fatty acid profiles. Acta vet (Beograd) 2009; 59:569-78.

50. Fidler N, Sauerwald T, Pohl A, Demmelmair H, Koletzko B: Docosahexaenoic acid transfer into human milk after dietary supplementation: a randomized clinical trial. J Lipid Res 200; 41(9):1376-83.

51. Jensen RG, Lammi-Keefe CJ, Henderson RA, Bush VJ, Ferris AM: Effect of dietary intake of n-6 and n-3 fatty acids on the fatty acid composition of human milk in North America. J Pediatr 1992; 120(4 Pt 2):S87-92.

Serbian Journal of Experimental and Clinical Research

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