Lifestyle Risk Factors in the Development of Kidney Cancer: A Russian Experience

Open access


The objective of our study was the evaluation of major lifestyle risk factors for the development of renal cell carcinoma (RCC) and the assessment of chances of developing this disease among inhabitants in the region, in the presence of and with combinations of the studied risk factors. Risk factors for developing RCC that are associated with lifestyle (smoking, obesity and hypertension) were observed in 500 patients with RCC aged 30-64 years who were investigated at the Krasnoyarsk Oncology Dispensary (study group) and 858 participants in the Krai (control group). The results of our study showed that smoking increases the risk of developing RCC 2.9 times and arterial hypertension 3.3 times in men; in women, obesity and hypertension increased these risks 2.6 and 3.2 times, respectively. All three risk factors were combined in 13.6% of men and in 8.4% of women with RCC. Our data may be useful for the prevention, development of screening programmes and early diagnosis of RCC.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans (Electronic resource). - Lyon France: International Agency for Research on Cancer 2011.

  • 2. Guidelines on renal cell carcinoma (Electronic resource) / B. Ljungberg N. Cowan D. C. Hanbury (et al.). EuropeanAssociation of Urology 2013.

  • 3. Cogliano VJ Baan R Straif K et al. Preventable exposures associated with human cancers. J Natl Cancer Inst. 2011;103(24):1827-39.

  • 4. Macleod LC Hotaling JM Wright JL et al. Risk factors for renal cell carcinoma in the VITAL study. J Urol. 2013;190(5):1657-61.

  • 5. Hunt JD van der Hel OL McMillan GP Boffetta P Brennan P. Renal cell carcinoma in relation to cigarette smoking: meta-analysis of 24 studies. Int J Cancer. 2005;114(1):101-8.

  • 6. Adams KF Leitzmann MF Albanes D et al. Body size and renal cell cancer incidence in a large US cohort study. Am J Epidemiol. 2008;168(3):268-77.

  • 7. Renehan AG Tyson M Egger M Heller RF Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371(9612):569-78.

  • 8. Luo J Margolis KL Adami HO Lopez AM Lessin L Ye W; Women’s Health Initiative Investigators. Body size weight cycling and risk of renal cell carcinoma among postmenopausal women: the Women’s Health Initiative (United States). Am J Epidemiol. 2007;166(7):752-9.

  • 9. Klinghoffer Z Yang B Kapoor A Pinthus JH. Obesity and renal cell carcinoma: epidemiology underlying mechanisms and management considerations. Expert Rev Anticancer Ther. 2009;9(7):975-87.

  • 10. Moore SC Chow WH Schatzkin A et al. Physical activity during adulthood and adolescence in relation to renal cell cancer. Am J Epidemiol. 2008;168(2):149-57.

  • 11. Corrao G Scotti L Bagnardi V Sega R. Hypertension antihypertensive therapy and renal-cell cancer: a metaanalysis. Curr Drug Saf. 2007;2(2):125-33.

  • 12. Setiawan VW Stram DO Nomura AM Kolonel LN Henderson BE. Risk factors for renal cell cancer: the multiethnic cohort. Am J Epidemiol. 2007;166(8):932-40.

  • 13. Gago-Dominguez M Castelao JE Yuan JM Ross RK Yu MC. Lipid peroxidation: a novel and unifying concept of the etiology of renal cell carcinoma (United States). Cancer Causes Control. 2002;13(3):287-93.

  • 14. SharifiN Farrar WL. Perturbations in hypoxia detection: a shared link between hereditary and sporadic tumor formation? Med Hypotheses. 2006;66(4):732-5.

  • 15. Report on the results of a sociological survey to assess public opinion on the quality of diagnostic services and coverage of educational information within the long-term targeted program “Prevention and control of socially significant diseases” for 2011-2013. - Krasnoyarsk: The Locomotive of Innovation 2011. – Section IV. - 182 sec.

  • 16. Global survey of the adult population on tobacco consumption. Russian Federation 2009. Country report. - M.: (B.I.) 2009. - 171 p. Parkin D. M.

  • 17. Parkin DM Boyd L Walker LC. 16. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010. Br J Cancer. 2011;105 Suppl 2:S77-81.

  • 18. Global Database on Body Mass Index (Electronic resource) // WHO. – URL :

  • 19. The ESC Textbook of Cardiovascular Medicine / eds. A. J. Camm T. F. Luscher P. Serruys. – USA : Wiley-Blackwell 2006. – 1136 p.

  • 20. State report on the health of the population and the health of the Krasnoyarsk Territory in 2012. - Krasnoyarsk:KKMIATS 2013 - 344 p.

Journal information
Impact Factor

CiteScore 2018: 0.13

SCImago Journal Rank (SJR) 2018: 0.118
Source Normalized Impact per Paper (SNIP) 2018: 0.079

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 388 207 7
PDF Downloads 154 101 1