Cutaneous larva migrans (CLM) is a parasitic skin disease caused by the accidental percutaneous penetration and subsequent intraepidermal migration of larvae of various nematode parasites of the hookworm family. The hookworms responsible for CLM are spread worldwide, but the infection occurs mostly in tropical and subtropical climates. Nowadays, because of ever increasing foreign travel, the disease is no longer confined to these areas. Moreover, a significant increase of autochthonous cases in southern Europe has been observed in recent years. We report two new patients from Serbia who acquired CLM, none of them having traveled abroad. As the recommendations for the treatment of CLM are not uniform, two different treatment modalities were applied in these patients, both with an excellent response.
1. Tomovic M, Skiljevic D, Zivanovic D, Tanasilovic S, Vesic S, Djakovic Z, et al. Two cases of probable endogenous extensive cutaneous larva migrans in Serbia. Acta Dermatovenerol Alp Pannonica Adriat. 2008;17(1):37-40.
2. Meotti CD, Plates G, Nogueira LL, Silva RA, Paolini KS, Nunes EM, et al. Cutaneous larva migrans on the scalp: atypical presentation of a common disease. An Bras Dermatol. 2014;89(2):332-3.
3. Tekely E, Szostakiewicz B, Wawrzycki B, Kądziela-Wypyska G, Juszkiewicz-Borowiec M, Pietrzak A, et al. Cutaneous larva migrans syndrome: a case report. Postepy Dermatol Alergol. 2013;30(2):119-21.
4. Heukelbach J, Feldmeier H. Epidemiological and clinical characteristics of hookworm-related cutaneous larva migrans. Lancet Infect Dis. 2008;8(5):302-9.
5. Miljković J, Breznik V. Cutaneous larva migrans in two Slovenian travelers returning from Brazil. Acta Dermatovenerol Alp Pannonica Adriat. 2008;17(2):83-5.
6. Nurjahan MI, Tevaraj P. Rash in a foreign worker. Malays Fam Physician. 2016;11(2-3):39-41.
7. Aljasser MI, Lui H, Zeng H, Zhou Y. Dermoscopy and near-infrared fluorescence imaging of cutaneous larva migrans. Photodermatol Photoimmunol Photomed. 2013;29(6):337-8.
8. Veraldi S, Bottini S, Persico MC, La Vela V. Larva migrans cutanea. Rome: Mediprint; 2010. p. 39-41.
9. Veraldi S, Persico MC, Francia C, Schianchi R. Chronic hookworm-related cutaneous larva migrans. Int J Infect Dis. 2013;17(4):e277-9.
10. Panés-Rodríguez A, Piera-Tuneu L, López-Pestaña A, Ormaetxea-Pérez N, Gutiérrez-Támara P, Ibarbia-Oruezabal S, et al. Autochthonous cutaneous larva migrans infection in Guipúzcoa. Actas Dermosifiliogr. 2016;107(5):407-13.
11. Gutiérrez García-Rodrigo C, Tous Romero F, Zarco Olivo C. Cutaneous larva migrans, welcome to a warmer Europe. J Eur Acad Dermatol Venereol. 2017;31(1):e33-5.
12. Vano-Galvan S, Gil-Mosquera M, Truchuelo M, Jaén P. Cutaneous larva migrans: a case report. Cases J. 2009;2(1):112.
13. Tamminga N, Bierman WF, de Vries PJ. Cutaneous larva migrans acquired in Brittany, France. Emerg Infect Dis. 2009;15(11):1856-8.
14. Akkouche W, Ahmed SA, Sattin A, Piaserico S, Calistri A, De Canale E, et al. Autochthonous hookwormrelated cutaneous larva migrans disease in Northeastern Italy: a case report. J Parasitol. 2015;101(4):488-9.
15. Wolf P, Ochsendorf FR, Milbradt R. Current therapeutic possibilities in cutaneous larva migrans. Hautarzt. 1993;44(7):462-5.