Cheilitis Glandularis Apostematosa in a Female Patient – a Case Report

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Cheilitis is an inflammatory condition of the vermilion border of the lips, which is the junction between the skin and the mucosa. Cheilitis may arise as a primary disorder of the vermilion zone; the inflammation may extend from the nearby skin, or less often from the oral mucosa. Primary cheilitis lesions are either superficial or deep. Deep types include cheilitis glandularis (inflammatory changes and lip gland swelling), and granulomatous cheilitis (chronic swelling of the lip due to granulomatous inflammation mostly of unknown origin). Cheilitis glandularis is a rare condition that mostly affects the lower lip and it is characterized by nodular enlargement, reduced mobility and lip erosion. Based on clinical presentation, cheilitis glandularis may be classified into three subtypes: simplex (described as Puente and Acevedo), superficial suppurative (described by Baelz-Unna), and the most severe type - deep suppurative, also known as cheilitis glandularis apostematosa (Volkmann’s cheilitis) characterized by deep-seated inflammation forming abscesses and fistulous tracts. This is a case report of a female patient with a deep suppurative type of cheilitis affecting both lips. Treatment with systemic antibiotics (using antibiogram tests), corticosteroids and topical therapy resulted in significant improvement.

1.Stanojević M. Bolesti usana, jezika i usne duplje. U: Paravina M, Spalević Lj, Stanojević M, Tiodorović J, Binić I, Jovanović D. Dermatovenerologija, drugo dopunjeno izdanje. Medicinski fakultet Niš. Niš: Prosveta AD; 2006. str. 277-85.

2. Stoopler ET, Carrasco L, Stanton DC, Pringle G, Sollecito TP. Cheilitisglandularis: an unusual histopathologic presentation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;95:313-7.

3. Orlov S, Kojović D, Mirković B. Oralna medicina. Niš: Europrint; 2001. str. 27-37.

4. Louren SV, Gori LM, Boggio P, Nico MMS. Cheilitis glandularis in albinos: a report of two cases and review of histopathological fi ndings after therapeutic vermilionectomy. JEADV 2007;21:1265-7.

5. Taneja P, Singh N. Cheilitis glandularis: a clinical report. Int Chin J Dent 2002;2:2-4.

6. Weir TW, Johnson WC. Cheilitis glandularis. Arch Dermatol 1971;103:433-7.

7. Hillen U, Franckson T, Goos M. Cheilitis glandularis: a case report. Acta Derm Venereol 2004;84:77-9.

8. Yacobi R, Brown DA. Cheilitis glandularis: a paediatric case report. J Am Dent Assoc 1989; 118:317-8.

9. Matsumoto H, Kurachi Y, Nagumo M. Cheilitis glandularis: report of a case aff ecting upper lip. Showa Shigakkai Zasshi 1989;9:441-5.

10. Yanagawa T, Yamaguchi A, Harada H, Yamagata K, Ishibashi N, Noguchi M, et al. Cheilitis Glandularis: two case reports of Asian-Japanese men and literature rewiew of Japanese cases. ISRN Dentistry 2011; Article ID 457567, 6 pages doi: lo.5402/2011/457567.

11. Lederman DA. Suppurative stomatitis glandularis. Oral Surg Oral Med Oral Pathol 1994; 78:319-22.

12. Mirowski GW, Parker ER. Biology and pathology of the oral cavity. In: Wolf K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leff el DJ, eds. Fitzpatrik’s dermatology in general medicine. 7th ed. New York: McGraw Hill Medical; 2008. p. 641-53.

13. Leao JC, Ferreira AMC, Martins S, Jardim ML, Barret W, Sculi C, et al. Cheilitis glandularis: an unusual presentation in a patient with HIV infection. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;95:142-4.

14. Von Volkmann R. Einigefalle von Cheilitisglandularisapostematosa. Arch Pathol Anal 1870;50:142-4.

15. Carrington PR, Horn TD. Cheilitis glandularis: a clinical marker for both malignancy and/or severe inflammatory disease of the oral cavity. J Am Acad Dermatol 2006;54:336-7.

16. Binić I, Janković A. Heilitisi: etiologija i mogućnosti lečenja. U: Karadaglić Đ, Jovanović M, ur. Bolesti sluzokože usne duplje: šta je novo? Beograd: Monografi je naučnih skupova AMN SLD; 2010;1(2):37-53.

17. Nico MMS, de Melo JN, Lourenco SV. Cheilitis glandularis: a clinicopathological study in 22 patients. J Am Acad Dermatol 2010;62:233-8.

18. Butt FM, Chindia ML, Ashani A. Cheilitis glandularis progressing to squamous carcinoma in an hiv-infected patient: case report. East Afr Med J 2007;84(12):595-8.

19. Swerlick RA, Cooper PH. Cheilitis glandularis: a reevaluation. J Am Acad Dermatol 1984;10 466-72.

20. Rada DC, Koranda FC, Katz FS. Cheilitis glandularis: a disorder of ductal ectasia. J Dermatol Surg Oncol 1985;11:372-5.

21. Neville B, Damm D, Alen C, Bouquet J. editors. Oral and maxillofacial pathology. 2nd ed. Philadelphia: W.B. Saunders; 2002. p. 389-435.

22. Stuller CB, Schaberg SJ, Stokos J, Pierce GL. Cheilitis glandularis. Oral Surg 1982;53: 602-5.

23. Winchester L, Scully C, Prime SS, Eveson JW. Cheilitis glandularis: a case aff ecting the upper lip. Oral Surg Oral Med Oral Pathol 1986;62:654-6.

24. Williams HK, Williams DM. Persistent sialadenitis of the minor glands - stomatitis glandularis. Br J Oral Maxillofac Surg 1989;27:212-6.

25. Bender MM, Rubenstein M, Rosen T. Cheilitis glandularis in an African-American woman: reponse to antibiotic therapy. Skinme 2005;4(6):312-7.

26. Michalowski R. Cheilitis glandularis, heterotopic salivary glands and squamous cell carcinoma of the lip. Br J Dermatol 1962;72:445-9.

27. Rogers RS, Bekic M. Diseases of the lips. Semin Cutan Med Surg 1997;16:328-36.

28. Haldar B. Cheilitis glandularis treated by injection of intralesional triamcinolone. Indian J Dermatol 1976;21:53-4.

29. Verma S. Cheilitis glandularis: a rare entity. Br J Dermatol 2003;148:3.

Serbian Journal of Dermatology and Venereology

The Journal of Serbian Association of Dermatovenereologists (SAD)

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