Myasthenia Gravis – a beginning with no end

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Myasthenia gravis is one of the neurological diseases with a relatively recent history, full of mistakes, in which the British and German neurology schools have attempted to find answers when confronted with the unknown. The paper aims at making a historical account of the disease from its discovery in the 16th century, when the first case of myasthenia gravis was medically diagnosed, to the beginning of the 20th century, when the dawn of modern therapy started to show.

1. Afifi AK. Myasthenia gravis from Thomas Willis to the present. Neurosciences (Riyadh). 2005; 10(1): 3-13.

2. Cunha FM, Scola RH, Werneck LC. Myasthenia gravis. Historical aspects. Arq Neuropsiquiatr. 1999; 57(2B):531-536.

3. Dreschfeld J. On a case of polioencephalomyelitis without any anatomical lesions. Brit Med J. 1893; 2:176-177.

4. Eadie MJ. Samuel Wilks (1824-1911): neurologist and generalist of the Mid-Victorian Era. J Med Biogr. 2008; 16(4):215-220.

5. Eisenlohr C. Ein fall von opthalmoplegia externa progressive und finaler bulbarparalzse mit negative sections-befund. Neurol Centralblat. 1887; 6: 337-390.

6. Erb WH. Handbook of Electrotherapeutics. New York: William Woods, 1833.

7. Eycleshymer AC. Anatomical names. New York: W. Wood, 1917.

8. Finger S, Boller F, Tyler KL. History of Neurology: Handbook of Clinical Neurology. Edinburg: Elsevier, 2009.

9. Fortuine R. The words of medicine: sources, meanings, and delights. Springfield: Charles C Thomas Publisher, 2001.

10. Goldflam S. Ueber einen scheinarheilbaren bulbarparalytischen Symptomencomplex mit beheiligung der extremitaten. Deutsch Z. Nervenheilk. 1893; 4: 312-352.

11. Guthrie L. Myasthenia gravis in the seventeenth century. Lancet. 1903; 1: 330-331.

12. Hughes T. The early history of myasthenia gravis. Neuromuscul Disord. 2005; 15(12):878-886.

13. Hughes JT. Thomas Willis 1621-1675: His life and work. N engl J Med. 1933; 328: 816-817.

14. Iacob G. Writing in neurosurgery. Romanian Neurosurgery. 2016; XXX 1.

15. Jolly F. Ūber Myasthenia gravis pesudoparalytica. Berl Klin Wochenschr. 1895; 32:1-7.

16. Keesey J. The role of Herman Hope of Cincinnati in the initial clinical recognition of myasthenia gravis. Journal of the History of the Neurosciences. 2003; 2: 167-174.

17. Koehler PJ, Bruyn GW, Pearce JMS. Neurological Eponyms. Oxford: Oxford University Press, 2000.

18. Magiorkinis E, Diamantis A, Sidiropoulou K, Panteliadis C. Highights in the History of Epilepsy: The Last 200 Years. Epilepsy Res Treat. 2014; 2014: 1-13.

19. Marsteller HB. The first American case of myasthenia gravis. Archives of Neurology.1988; 45(2): 185-187.

20. Mimenza-Alvarado A, Tellez-Zenteno J, Garcia-Ramos G, Estanol B. The history of myasthenia gravis. Men and ideas. Neurologia. 2007; in press.

21. Oppenheim H. Ueber ein fall von chronischer progressive bulbar paralyse ohne anatomischen befund. Virch Archiv Path anat Phys. 1887; 180: 522-530.

22. Pearce JMS. Sir Samuel Wilks (1824-1911): The most philosophical of English physicians. Eur Neurol. 2009; 61:119-123.

23. Pearce JMS. Sir Samuel Wilks (1824–1911): On Epilepsy. Eur Neurol. 2009; 61:124–127.

24. Stone MJ. Samuel Wilks: the “grand old man” of British medicine. Proc (Bayl Univ Med Cent). 2010; 23(3): 263–265.

25. Viets HR. A historical review of myasthenia gravis from 1672 to 1900. JAMA. 1953; 153:1273-1280.

26. Weigert C. Pathologisch-anatomischer Beitrag zur Erb’schen Krankheit (miashenia gravis). Neurologisches Centralblatt. 1901; 20:597-601.

27. Wilks S. On cerebritis, hysteria and bulbar paralysis. Guy’s Hospital reports. 1877; 22:7-55.

28. Willis T. Pordage S. De anima brutorum. Two discourses concerning the soul of brutes, which is that of the vital and sensitive of man. London: Dring, 1683.

Romanian Neurosurgery

The Journal of Romanian Society of Neurosurgery

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