The Effect of Chewing a Sugar-Free Gum After Oatmeal on the Postprandial Glycaemia – A Cross-Over Study

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Background and Aims: Gum chewing after a meal stimulates salivation and may affect the motility of the gastrointestinal tract and the release of hormones through neural mechanisms. This study was conducted to assess if chewing a sugar-free gum for 20 min following a meal, as recommended for dental caries prevention, influences the postprandial blood glucose levels in a period of one hour. Materials and Methods: For each of 18 participants blood glucose profile was made by measuring capillary glucose concentration in 10-min intervals within one hour following: a) chewing a sugar-free gum, b) the consumption of an oatmeal, c) chewing a sugar-free gum after the consumption of an oatmeal. Results: No statistically significant differences were found in the glycaemic response following complex carbohydrate ingestion when a gum was chewed after a meal. Conclusions: The possible influence of gum chewing on the postprandial gastrointestinal and metabolic ongoings was not reflected in the postprandial glycaemic response under the conditions of this study. A more comprehensive study which would include more variables related to vagal efferent activity, digestion and metabolism would be needed to assess if chewing sugar-free gums to exploit their caries-protective potential can influence metabolic adaptability to nutritional challenges.

1. Beiswanger BB, Boneta AE, Mau MS, Katz BP, Proskin HM, Stookey GK. The effect of chewing sugarfree gum after meals on clinical caries incidence. J Am Dent Assoc 129: 1623-1626, 1998.

2. Szöke J, Bánóczy J, Proskin HM. Effect of after-meal sucrose-free gum-chewing on clinical caries. J Dent Res 80: 1725-1729, 2001.

3. Dawes C, Kubieniec K. The effects of prolonged gum chewing on salivary flow rate and composition. Arch Oral Biol 49: 665-669, 2004.

4. Dodds MWJ, Johnson DA, Yeh CK. Health benefits of saliva: a review. J Dent 33: 223-233, 2005.

5. Rohleder N, Nater UM. Determinants of salivary alpha-amylase in humans and methodological considerations. Psychoneuroendocrinology 34: 469-485, 2009.

6. Mandel AL, Peyrot des Gachons C, Plank KL, Alarcon S, Breslin PA. Individual differences in AMY1 gene copy number, salivary α-amylase levels, and the perception of oral starch. PLoS One 5:e13352, 2010.

7. Pedersen AM, Bardow A, Jensen SB, Nauntofte B. Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion. Oral Dis 8: 117- 129, 2002.

8. Read NW, Welch IM, Austen CJ et al. Swallowing food without chewing; a simple way to reduce postprandial glycemia. Br J Nutr 55: 43-47, 1986.

9. Suzuki H, Fukushima M, Okamoto S et al. Effects of thorough mastication on postprandial plasma glucose concentrations in nonobese Japanese subjects. Metabolism 54: 1593-1599, 2005.

10. Zhu Y, Hsu WH, Hollis JH. Increasing the number of masticatory cycles is associated with reduced appetite and altered postprandial plasma concentrations of gut hormones, insulin and glucose. Br J Nutr 110: 384- 390, 2013.

11. Mandel AL, Breslin PA. High endogenous salivary amylase activity is associated with improved glycemic homeostasis following starch ingestion in adults. J Nutr 142: 853-858, 2012.

12. Sakamoto Y, Kato S, Sekino Y et al. Change of gastric emptying with chewing gum: evaluation using a continuous real-time C breath test (BreathID system). J Neurogastroenterol Motil 17: 174-179, 2011.

13. Li J, Zhang N, Hu L et al. Improvement in chewing activity reduces energy intake in one meal and modulates plasma gut hormone concentrations in obese and lean young Chinese men. Am J Clin Nutr 94: 709-716, 2011.

14. Ohmure H, Takada H, Nagayama K, Sakiyama T, Tsubouchi H, Miyawaki S. Mastication suppresses initial gastric emptying by modulating gastric activity. J Dent Res 91: 293-298, 2012.

15. Morey S, Shafat A, Clegg ME. Oral versus intubated feeding and the effect on glycemic and insulinemic responses, gastric emptying and satiety. Appetite 96: 598-603, 2016.

16. Cohen J. Statistical power analysis for the behavioural sciences. 2nd ed. Lawrence Erlbaum Associates, Hillsdale, 1988.

17. Rosenblum JL, Irwin CL, Alpers DH. Starch and glucose oligosaccharides protect salivary-type amylase activity at acid pH. Am J Physiol 254(5 Pt 1): 775-780, 1988.

18. Björck I, Granfeldt Y, Liljeberg H, Tovar J, Asp NG. Food properties affecting the digestion and absorption of carbohydrates. Am J Clin Nutr 59 Suppl 3: S699-705, 1994.

19. Hoebler C, Karinthi A, Devaux MF et al. Physical and chemical transformations of cereal food during oral digestion in human subjects. Br J Nutr 80: 429-436, 1998.

20. Granfeldt Y, Nyberg L, Björck I. Muesli with 4 g oat beta-glucans lowers glucose and insulin responses after a bread meal in healthy subjects. Eur J Clin Nutr 62: 600-607, 2008.

21. Helman CA. Chewing gum is as effective as food in stimulating cephalic phase gastric secretion. Am J Gastroenterol 83: 640-642, 1988.

22. Woolnough JW, Bird AR, Monro JA, Brennan CS. The effect of a brief salivary α-amylase exposure during chewing on subsequent in vitro starch digestion curve profiles. Int J Mol Sci 11: 2780-2790, 2010.

23. Ranawana V, Clegg ME, Shafat A, Henry CJ. Postmastication digestion factors influence glycemic variability in humans. Nutr Res 31: 452-459, 2011.

24. Kresge DL, Melanson K. Chewing gum increases energy expenditure before and after controlled breakfasts. Appl Physiol Nutr Metab 40: 401-406, 2015.

25. Teff KL, Levin BE, Engelman K. Oral sensory stimulation in men: effects on insulin, C-peptide, and catecholamines. Am J Physiol 265(6 Pt 2): 1223-1230, 1993.

26. Teff KL, Engelman K. Oral sensory stimulation improves glucose tolerance in humans: effects on insulin, C-peptide, and glucagon. Am J Physiol 270(6 Pt 2): 1371- 1379, 1996.

27. Zhu Y, Hsu WH, Hollis JH. Modified sham feeding of foods with different macronutrient compositions differentially influences cephalic change of insulin, ghrelin, and NMR-based metabolomic profiles. Physiol Behav 135: 135-142, 2014.

28. Lorentzen M, Madsbad S, Kehlet H, Tronier B. Effect of sham-feeding on glucose tolerance and insulin secretion. Acta Endocrinol (Copenh) 115: 84-86, 1987.

29. Andersen HB, Christiansen E, Vølund A et al. Sham feeding increases glucose tolerance by a mechanism independent of insulin secretion in normal subjects. Digestion 56: 253-258, 1995.

30. Teff KL. Cephalic phase pancreatic polypeptide responses to liquid and solid stimuli in humans. Physiol Behav 99: 317-323, 2010.

31. Katschinski M. Nutritional implications of cephalic phase gastrointestinal responses. Appetite 34: 189-196, 2000.

32. Suez J, Korem T, Zeevi D et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature 514: 181-186, 2014.

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

The Journal of Romanian Society of Diabetes Nutrition and Metabolic Diseases

Journal Information

CiteScore 2018: 0.19

SCImago Journal Rank (SJR) 2018: 0.128
Source Normalized Impact per Paper (SNIP) 2018: 0.229


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