Background and Aims: In Nigeria, community-based epidemiological data related to the prevalence of zinc deficiency in preschool children are scarce. We assessed the prevalence of zinc deficiency and the associated socio-demographic variables in children aged between 6 and 60 months, living in a Nigerian rural community.
Materials and Methods: In this cross-sectional study, the serum zinc concentrations of 252 children aged between 6 and 60 months in a rural community in Nigeria were assessed, using atomic absorption spectrophotometry. The study population was selected by multistage random sampling and at least two children were selected from every household which had children in the study age group. The socio-demographic characteristics of the subjects were obtained, using an interviewer-administered questionnaire.
Results: A total of 252 children were studied, 134 (53.2%) males and 118 (46.8%) females. The mean age was 32.7±17.0 months, similar for both sexes. Overall, 220 (87.3%) had low serum zinc concentrations (less than 7.65µmol/L). According to age, the highest mean serum zinc concentration was 5.43±3.52µmol/L in children aged between 6 and 12 months. Correlation between serum zinc concentration and family size or socio-economic status (SES) showed that the smaller the family size and the higher the SES, the higher the serum zinc concentration.
Conclusions: The high prevalence of low serum zinc concentration indicates that zinc deficiency is a public health problem in our rural communities, requiring public health intervention.
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1. Dibley MJ. Zinc. In: Present Knowledge in Nutrition 8th edition. Bowman BA Russel RM (eds). ILSI Press Washington DC pp. 329-343 2001.
2. Chasapis CT Loutsidou AC Spiliopoulou CA Stefanidou ME. Zinc and human health: an update. Arch Toxicol 86: 521-534 2012.
3. Gropper SS Smith JL Groff JL.Advanced Nutrition and Human Metabolism 4th edition. Wadsworth Behmont CA pp. 436-446 2005.
4. Hambidge M Krebs NF. Zinc metabolism and requirements. Food Nutr Bull 22: 126-132 2001.
5. Cousins RJ. Systemic transport of zinc. In: Zinc in Human Biology Mills CF (ed). Springer-Verag New York pp. 79-93 1989.
6. Kumosani TA Abdul-Jabbar HS Al-Tazi ZA. Serum zinc levels of healthy individuals living in the western province of Saudi Arabia. Ain Shams Med J 48: 797-802 1997.
7. Wessells KR King JC Brown KH. Development of a plasma zinc concentration cut-off to identify based on results from adults undergoing experimental severe dietary zinc restriction and individuals with acrodermatitis enteropathica. J Nutr 144: 1204-1210 2014.
8. King JC. Assessment of zinc status. J Nutr 120[Suppl. 11]: 1474-1479 1990.
9. Wood RJ. Assessment of marginal zinc status in humans. J Nutr 130[5S Suppl]: 1350S-1354S 2000.
10. Gibson RS. Assessment of trace element status in humans. Prog Food Nutr Sci 13: 67-111 1989.
11. Brown KH. Effect of infections on plasma zinc concentration and implications for zinc status assessment in low-income countries. Am J Clin Nutr 68(2 Suppl): 425S-429S 1998.
12. Gulati A Paul VK. Micronutrients in health and disease. In: Essential Pediatrics 7th edition. Ghai OP Paul VK Bagga A (eds). CBS Publishers New Delhi pp. 78-95 2009.
13. Tielsch JM Kharrty SK Stotzfus RJ et al. Effect of daily zinc supplementation on child mortality in southern Nepal: a community-based cluster randomized placebo-controlled trial. Lancet 370: 1230-1239 2007.
14. Fesharakinia A Zarban A Sharrifzadeh GR. Prevalence of zinc deficiency in elementary school children of South Khorasan Province (East Iran). Iranian J Pediatr 19: 249-254 2009.
15. Galetti V Mitchikpe CES Kujinga P et al. Rural Beninese children are at risk of zinc deficiency according to stunting prevalence and plasma zinc concentration but not dietary zinc status. J Nutr 146: 114-123 2016.
16. de Benoist B Damton-Hill I Davidson L Fontaine O Hotz C. Conclusions of the Joint WHO/UNICEF/IAEA/IZiNCG interagency meeting on zinc status indicators. Food Nutr Bull 28(3 Suppl): S480-S484 2007.
17. Federal Ministry of Health Nigeria Nutrition Division. National Guidelines on Micronutrients Deficiencies Control in Nigeria. Monograph pp. 38-46 2005.
18. Bilbis LS Saidu Y Aliyu RU. Serum vitamin A and zinc levels of some preschool children in Sokoto metropolis of Nigeria. Biokemistri 14: 82-87 2003.
19. Fischer Walker CL Ezzati M Black RE. Global and regional child mortality and burden of disease attributable to zinc deficiency. Eur J Clin Nutr 63: 591-597 2009.
20. Ploysangam A Falciglia G Brehm B. Effect of marginal zinc deficiency on human growth and development. J Trop Pediatr 43: 192-198 1997.
21. Gibson RS. Zinc: the missing link in combating micronutrients malnutrition in developing countries. Proc Nutr Soc 65: 51-60 2006.
22. El-Ghareeb AS Shaker RHM Shahin AMS Abed NT El Bathyony G. Zinc deficiency and gastrointestinal parasite infection among children. Int J Med Health Sci 4: 47-54 2015.
23. Lazarte CE Soto A Alvarez L Bergenstahl B Medrano N Granfeldt Y. Nutritional status of children with intestinal parasites from a tropical area of Bolivia emphasis on zinc and iron status. Food Nutr Sci 6: 399-411 2015.
24. Bartlett JE Kotrlik JW Higgins CC. Organizational research: Setermining appropriate sample size in survey research. Information Technol Learning Performance J 19: 43-50 2001.
25. Olusanya O Okpere E Ezimokhai M. The importance of social class in voluntary fertility control in a developing country. West Afr J Med 3: 76-78 1985.
26. Engle-Stone R Ndjebayi AO Nankap M Killilea DW Brown KH. Stunting prevalence plasma zinc concentrations and dietary zinc intakes in a nationally representative sample suggest a high risk of zinc deficiency among women and young children in Cameroon. J Nutr 144: 382-391 2014.
27. Ibeanu V Okeke E Onyechi U Ejiofor U. Assessment of anthropometric indices and zinc status of preschoolers in peri-urban community in south east Nigeria. Int J Basic Appl Sci 12: 31-37 2012.
28. Onyemaobi GA Onimawo IA. Zinc status of under-five children in rural and urban Imo State Nigeria. J Basic Appl Sci Res 1: 451-455 2011.
29. Liu J Ai YX Hanlon A Shi Z Dickerman B Compher C. Micronutrient deficiency and socio-demographic factors in Chinese children. World J Pediatr 7: 217-223 2011.
30. Abah RO Okolo SN John C Ochoga MO. Prevalence of zinc deficiency among school children in a rural setting in North-central Nigeria. Inter J Public Health Res 3: 214-217 2015.
31. Cole CR Grant FK Swaby-Ellis ED et al. Zinc and iron deficiency and their interrelation in low income African American and Hispanic children in Atlanta. Am J Clin Nutr 91: 1027-1034 2010.
32. Dhingra U Hiremath G Menon VP Dhingra P Sarkar A Sazawal S. Zinc deficiency: Descriptive epidemiology and morbidity among preschool children in peri-urban population in Delhi India. J Health Popul Nutr 27: 632-639 2009.
33. Dey I Chaudhuri RN. Gender inequality in nutritional status among under five children in a village in Hooghly district West Bengal. Indian J Public Health 52: 218-220 2008.
34. Baig-Ansari N Rahbar MH Bhutta ZA Badruddin SA. Child’s gender and household food security are associated with stunting among young Pakistani children residing in urban squatter settlements. Food Nutr Bull 27: 114-127 2006.
35. Patel KA Langare SD Naik JD Rajderkar SS. Gender inequality and biosocial factors in nutritional status among uner five children attending anganwadis in an urban slum of a town in western Maharashtra India. J Res Med Sci 18: 341-345 2013.