The relationship between periodontal disease and diabetes mellitus

Open access


Periodontitis is a common complication in patients with diabetes. Their classification is complex and it is based on the clinical presentation, rate of disease progression, age at diagnosis and local and systemic factors that may multiply the risk. The two major stages of periodontal diseases are gingivitis and periodontitis. The relationship between these two diseases appears bidirectional insofar that the existence of one disease tends to promote the other and that the meticulous management of either may help the treatment of the other. Treatment of periodontitis using a association of mechanical therapy, scaling and root planning, plus systemic tetracycline antibiotics has been demonstrated to have important reductions in HbA1c values. Therefore, for a better control of diabetes we suggest that periodontal patients with diabetes should be consulted and treated by a periodontist.

1. Preshaw PM, Alba AL, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K, and Taylor R. Periodontitis and diabetes: a two-way relationship, Diabetologia January; 55(1): 21-31, 2012.

2. Papapanou PN. Periodontal diseases: Epidemiology. Ann Periodontol 1: 1-36, 1996.

3. Page RC, Offenbacher S, Schroeder HE, Seymour GJ, Kornman KS. Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontol 14: 216-248, 199, 2000.

4. Janet H, Southerland DDS, MPH, PhD, George W Taylor, DMD, DrPH and Steven Offenbacher. Diabetes and Periodontal Infection: Making the Connection, Clinical Diabetes October vol. 23 no. 4 171-178, 2005.

5. Lo¨e H. Periodontal disease. The sixth complication of diabetes mellitus. Diabetes Care 16(Suppl. 1): 329-334, 1993.

6. Emrich LJ, Shlossman M, Genco RJ. Periodontal disease in insulin-dependent diabetes mellitus. J Periodontol 62: 123-131, 1991.

7. Brian L Mealey, Thomas W Oates. Diabetes Mellitus and Periodontal Diseases, J Periodontol August, 2006.

8. Chandna S, Bathla M, Madaan V, Kalra S. Diabetes Mellitus - A Risk Factor For Periodontal Disease. The Internet Journal of Family Practice Volume 9 Number 1, 2010.

9. Nagata T. Relationhip between diabetes and periodontal disease, Clin Calcium Sep; 19(9): 1291-8, 2009.

10. Albander JM, Brunelle JA, Kingman A. Destructive periodontal disease in adults 30years of age and older in United States. J Periodontol 70: 13-29, 1999.

11. Tervonen T, Knuuttila M. Relation of diabetes control to periodontal pocketing and alveolar bone level. Oral Surg Oral Med Oral Pathol 61: 346-9, 1986.

12. Firatli E. The relation between clinical periodontal status and insulin dependent diabetes mellitus. J Periodontol 68: 136-40, 1997.

13. Kalyani Deshpande, Ashish Jain, RaviKant Sharma, Savita Prashar and Rajni Jain. Diabetes and periodontitis, J Indian Soc Periodontol Oct-Dec; 14(4): 207-212, 2010.

14. Bascones A, Gamonal J, Gomez M, Silva A, Gonzalez MA. New knowledge of the pathogenesis of periodontal disease. Quintessence Int 35: 706-16, 2004.

15. Janket SJ, Wightman A, Baird AE, Van Dyke TE, Jones JA. Does periodontal treatment improve glycemic control in diabetic patients? A metaanalysis of intervention studies. J Dent Res 84: 1154-9, 2005.

16. Serrano-Ríos M, Corbatón A. Diabetes mellitus, heart failure and mortality. Med Clin (Barc). 125: 182-3, 2005.

17. Antonio Bascones-Martinez 1, Paula Matesanz-Perez 1, Marta Escribano-Bermejo 1, Miguel-Ángel González- Moles 2, Jaime Bascones-Ilundain 1, Jukka-H Meurman. Periodontal disease and diabetes-Review of the literature, Med Oral Patol Oral Cir Bucal Sep 1; 16 (6): e722-9, 2011.

18. Miller LS, Manwell MA, Newbold D et al. The relationship between reduction in periodontal inflammation and diabetes control: a report of 9 cases. J Periodontol 63: 843-848, 1992.

19. Iwamoto Y, Nishimura F, Nakagawa M, et al. The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes. J Periodontol 72: 774-778, 2001.

20. Grossi SG, Skrepcinski FB, DeCaro T et al. Treatment of periodontal disease in diabetics reduces glycated hemoglobin. J Periodontol 68: 713-719, 1997.

21. Brian L Mealey, Michael P Rethman. Periodontal Disease and Diabetes Mellitus: Bidirectional Relationship, Dentistry Today 01 April 2003.

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

The Journal of Romanian Society of Diabetes Nutrition and Metabolic Diseases

Journal Information

CiteScore 2018: 0.19

SCImago Journal Rank (SJR) 2018: 0.128
Source Normalized Impact per Paper (SNIP) 2018: 0.229


All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 523 350 36
PDF Downloads 204 152 8