Mesenteric fibromatosis with intestinal involvement mimicking a gastrointestinal stromal tumour

Open access

Mesenteric fibromatosis with intestinal involvement mimicking a gastrointestinal stromal tumour

Introduction. Mesenteric fibromatosis or intra-abdominal desmoid tumour is a rare proliferative disease affecting the mesentery. It is a locally aggressive tumour that lacks metastatic potential, but the local recurrence is common. Mesenteric fibromatosis with the intestinal involvement can be easily confused with other primary gastrointestinal tumours, especially with that of the mesenchymal origin.

Case report. We report a case of a 44-year-old female who presented with an abdominal mass that radiologically and pathologically mimicked a gastrointestinal stromal tumour.

Conclusions. The diagnosis of mesenteric fibromatosis should always be considered in the case of mesenchymal tumours apparently originating from the bowel wall that diffusely infiltrate the mesentery.

Zhou YL, Boardman LA, Miller RC. Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines. Radiol Oncol 2010; 44: 57-61.

Gurbuz AK, Giardiello FM, Petersen GM, Krush AJ, Offerhaus GJ, Booker SV, et al. Desmoid tumours in familial adenomatous polyposis. Gut 1994; 35: 377-81.

Bridge JA, Sreekantaiah C, Mouron B, Neff JR, Sandberg AA, Wolman SR. Clonal chromosomal abnormalities in desmoid tumors. Implications for histopathogenesis. Cancer 1992; 69: 430-6.

Alman BA, Li C, Pajerski ME, Diaz-Cano S, Wolfe HJ. Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors). Am J Pathol 1997; 151: 329-34.

Biasco G, Pantaleo MA, Nobili E, Monti C. Spontaneous regression of a desmoid intraabdominal tumor in a patient affected by familial adenomatous polyposis. Am J Gastroenterol 2004; 99: 1621-2.

Smith AJ, Lewis JJ, Merchant NB, Leung DH, Woodruff JM, Brennan MF. Surgical management of intra-abdominal desmoid tumours. Br J Surg 2000; 87: 608-13.

Lev D, Kotilingam D, Wei C, et al. Optimizing treatment of desmoid tumors. J Clin Oncol 2007; 25: 1785-91.

Gronchi A, Casali PG, Mariani L, Lo Vullo S, Colecchia M, Lozza L, et al. Quality of surgery and outcome in extra-abdominal aggressive fibromatosis: a series of patients surgically treated at a single institution. J Clin Oncol 2003; 21: 1390-7.

Bertagnolli MM, Morgan JA, Fletcher CD, Raut CP, Dileo P, Gill RR, et al. Multimodality treatment of mesenteric desmoid tumours. Eur J Cancer 2008; 44: 2404-10.

Wcislo G, Szarlej-Wcislo K, Szczylik C. Control of aggressive fibromatosis by treatment with imatinib mesylate. A case report and review of the literature. J Cancer Res Clin Oncol 2007; 133: 533-8.

Zokalj I, Culinovic-Caic R, Magas Z, Pavcec Z, Saghir H, Igrec J, et al. Gastric gastrointestinal stromal tumour. Radiol Oncol 2008; 42: 187-95.

Yantiss RK, Spiro IJ, Compton CC, Rosenberg AE. Gastrointestinal stromal tumor versus intra-abdominal fibromatosis of the bowel wall: a clinically important differential diagnosis. Am J Surg Pathol 2000; 24: 947-57.

Rodriguez JA, Guarda LA, Rosai J. Mesenteric fibromatosis with involvement of the gastrointestinal tract. A GIST simulator: a study of 25 cases. Am J Clin Pathol 2004; 121: 93-8.

Colombo P, Rahal D, Grizzi F, Quagliuolo V, Roncalli M. Localized intraabdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: a case report. World J Gastroenterol 2005; 11: 5226-8.

Bhattacharya B, Dilworth HP, Iacobuzio-Donahue C, Ricci F, Weber K, Furlong MA, et al. Nuclear beta-catenin expression distinguishes deep fibromatosis from other benign and malignant fibroblastic and myofibroblastic lesions. Am J Surg Pathol 2005; 29: 653-9.

Montgomery E, Torbenson MS, Kaushal M, Fisher C, Abraham SC. Betacatenin immunohistochemistry separates mesenteric fibromatosis from gastrointestinal stromal tumor and sclerosing mesenteritis. Am J Surg Pathol 2002; 26: 1296-301.

Azizi L, Balu M, Belkacem A, Lewin M, Tubiana JM, Arrive L. MRI features of mesenteric desmoid tumors in familial adenomatous polyposis. AJR Am J Roentgenol 2005; 184:1128-35.

Wronski M, Cebulski W, Slodkowski M, Krasnodebski IW. Gastrointestinal stromal tumors: ultrasonographic spectrum of the disease. J Ultrasound Med 2009; 28: 941-8.

Ko SF, Lin JW, Ng SH, Huang CC, Wan YL, Huang HY et al. Spontaneous isolated mesenteric fibromatosis: sonographic and computed tomographic findings with pathologic correlation. Ultrasound Med Biol 2006; 32: 1141-9.

Levy AD, Rimola J, Mehrotra AK, Sobin LH. From the archives of the AFIP: benign fibrous tumors and tumorlike lesions of the mesentery: radiologic-pathologic correlation. Radiographics 2006; 26: 245-64.

Lau S, Tam KF, Kam CK, Lui CY, Siu CW, Lam HS et al. Imaging of gastrointestinal stromal tumour (GIST). Clin Radiol 2004; 59: 487-98.

Lee CK, Hadley A, Desilva K, Smith G, Goldstein D. When is a GIST not a GIST? A case report of synchronous metastatic gastrointestinal stromal tumor and fibromatosis. World J Surg Oncol 2009; 7: 8.

Komatsu S, Ichikawa D, Kurioka H, Koide K, Ueshima Y, Shioaki Y, et al. Intra-abdominal desmoid tumor mimicking lymph node recurrence after gastrectomy for gastric cancer. J Gastroenterol Hepatol 2006; 21: 1224-6.

Radiology and Oncology

The Journal of Association of Radiology and Oncology

Journal Information


IMPACT FACTOR 2017: 1.722
5-year IMPACT FACTOR: 1.729

CiteScore 2017: 1.84

SCImago Journal Rank (SJR) 2017: 0.574
Source Normalized Impact per Paper (SNIP) 2017: 0.814


Cited By

Metrics

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 234 204 19
PDF Downloads 63 59 6