In search of the shortest regimen: fractionation of a fully isoeffective combination of hyperfractionated and hypofractionated treatment

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In search of the shortest regimen: fractionation of a fully isoeffective combination of hyperfractionated and hypofractionated treatment

Purpose. To analyze the possibility of reducing the number of fractions but maintaining the full biological effect of radiotherapy by varying the dose per fraction.

Methods. An arbitrary treatment with a constant dose per fraction is substituted for a fully isoeffective combination of a hyperfractionated and hypofractionated treatment. The number of fractions of the combined treatment is derived. All calculations are based on the linear-quadratic model.

Conclusions. Standard uniform fractionation requires the fewest fractions. Any variation in dose per fraction increases the number of fractions of a fully isoeffective treatment.

Steel GG. Cell survival as a determinant of tumour response. In: Steel GG, editor. Basic clinical radiobiology. 3rd ed. London: Arnold; 2002. p. 52-63.

Joiner MC, Bentzen SM. Time-dose relationships: the linear-quadratic approach. In: Steel GG, editor. Basic clinical radiobiology. 3rd ed. London: Arnold; 2002. p. 120-33.

Horsman MR, Overgaard J. The oxygen effect and tumour microenvironment. In: Steel GG, editor. Basic clinical radiobiology. 3rd ed. London: Arnold; 2002. p. 158-68.

Joiner MC. A simple α/β-independent method to derive fully isoeffective schedules following changes in dose per fraction. Int J Radiat Oncol Biol Phys 2004; 58: 871-5.

Bortfeld T, Paganetti H. The biological relevance of daily dose variations in adaptive treatment planning. Int J Radiat Oncol Biol Phys 2006; 64: 899-906.

Radiology and Oncology

The Journal of Association of Radiology and Oncology

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