The purpose of this paper is to investigate identities with Jordan *-derivations in semiprime *-rings. Let ℛ be a 2-torsion free semiprime *-ring. In this paper it has been shown that, if ℛ admits an additive mapping D : ℛ→ℛsatisfying either D(xyx) = D(xy)x*+ xyD(x) for all x,y ∈ ℛ, or D(xyx) = D(x)y*x*+ xD(yx) for all pairs x, y ∈ ℛ, then D is a *-derivation. Moreover this result makes it possible to prove that if ℛ satis es 2D(xn) = D(xn−1)x* + xn−1D(x) + D(x)(x*)n−1 + xD(xn−1) for all x ∈ ℛ and some xed integer n ≥ 2, then D is a Jordan *-derivation under some torsion restrictions. Finally, we apply these purely ring theoretic results to standard operator algebras 𝒜(ℋ). In particular, we prove that if ℋ be a real or complex Hilbert space, with dim(ℋ) > 1, admitting a linear mapping D : 𝒜(ℋ) → ℬ(ℋ) (where ℬ(ℋ) stands for the bounded linear operators) such that
for all A∈𝒜(ℋ). Then D is of the form D(A) = AB−BA* for all A∈𝒜(ℋ) and some fixed B ∈ ℬ(ℋ), which means that D is Jordan *-derivation.