General Influence of Biphasic Calcium Phosphate on Osteoporotic Bone Density

Open access


Bone density of the femur body of rabbit was determined in vivo. Experimental osteoporosis was induced by ovariectomy and subsequent injections of methylprednisolone. In the greater trochanter region of right femur, defects were created and filled with granules of hydroxyapatite and tricalcium phosphate (HAP/TCP 70/30) or HAP/TCP 70/30 together with 5% strontium. After three months, the animals were euthanized. The bone mass density of the right and left body of femur was measured by cone beam computed tomography (CT) scan. The results of the study showed that the right femur of the rabbit, where biomaterials had been implanted, and the left femur, where no biomaterial implantation occurred, became denser after filling the defect with HAP/TCP 70/30 ceramic granules or 5% Sr modified HAP/TCP ceramic granules. There was no difference between operated and non-operated legs and HAP/TCP and HAP/TCP with 5% strontium groups.

Dimitriou, R., Jones, E., McGonagle, D., Giannoudis, P. V. (2011). Bone regeneration: Current concepts and future directions. BMC Med., 9, 66–71.

Ehret, C., Aid-Launais, R., Sagardoy, T., Siadous, R., Bareille, R., Rey, S., Pechev, S., Etienne, L., Kalisky, J., de Mones, E., Letourneur, D., Amedee Vilamitjana, J. (2017). Strontium-doped hydroxyapatite polysaccharide materials effect on ectopic bone formation. PLoS One, 12 (9), e0184663.

Kim, D. G. (2014). Can dental cone beam computed tomography assess bone mineral density? J. Bone Metab., 21 (2), 117–126.

Landi, E., Tampieri, A., Celotti, G., Sprio, S., Sandri, M., Logroscino, G. (2007). Sr-substituted hydroxyapatites for osteoporotic bone replacement, Acta Biomater., 3 (6), 961–969.

Li, Y., Luo, E., Zhu, S., Li, J., Zhang, L., Hu, J. (2015). Cancellous bone response to strontium-doped hydroxyapatite in osteoporotic rats. J. Appl. Biomater. Funct. Mater., 13 (1), 28–34.

Lode, A., Heiss, C., Knapp, G., Thomas, J., Nies, B., Gelinsky, M., Schumacher, M. (2017). Strontium-modified premixed calcium phosphate cements for the therapy of osteoporotic bone defects. Acta Biomater., 1, 30664–30665.

Ratner, B. D., Hoffman, A. S., Schoen, F. J., Lemons, J. E. (2013). Biomaterials Science: An Introduction to Materials in Medicine. 3rd edn. Elsevier. 1573 pp.

Saint-Jean, S. J., Camire, C. L., Nevsten, P., Hansen, S., Ginebra, M. P. (2005). Study of the reactivity and in vitro bioactivity of Sr-substituted α-TCP cement. J. Mater. Sci. Mater. Med., 16, 993–1001.

Salma, I., Petronis, S., Pilmane, M., Skagers, A., Zalite, V., Locs, J. (2015). Local recovery of bone tissue in osteoporotic rabbit hip after implantation of HAP/TCP bioceramic granules. In: 27th European Conference on Biomaterials: Final Programme and Book of Abstracts, Krakov, Poland, 30th August – 3rd September, 2015. Scientific Publishing House “Akapit”, Krakow, p. 409. Available at: (accessed 18.02.2019).

Schlickewei, C. W., Laaff, G., Andresen, A., Klatte, T. O., Rueger, J. M., Ruesing, J., Epple, M., Lehmann, W. (2015). Bone augmentation using a new injectable bone graft substitute by combining calcium phosphate and bisphosphonate as composite: An animal model. J. Orthop. Surg. Res., 10, 116.

Wang, W., Yeung, K. W. K. (2017). Bone grafts and biomaterials substitutes for bone defect repair: A review. Bioact. Mater., 2, 224–247.

Journal Information

CiteScore 2017: 0.22

SCImago Journal Rank (SJR) 2017: 0.127
Source Normalized Impact per Paper (SNIP) 2017: 0.211


All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 55 55 37
PDF Downloads 55 55 43