Allometric scaling of marbofloxacin pharmacokinetics: a retrospective analysis

Open access


The association between physiologically dependent pharmacokinetic parameters (CLB, T1/2β, Vdss) of marbofloxacin and body weight was studied in eight animal species based on allometric equation Y = aWb, where ‘Y’ is the pharmacokinetic parameter, ‘W’ is body weight, ‘a’ is allometric coefficient (intercept) and ‘b’ is the exponent that describes relation between pharmacokinetic parameter and body weight. The body clearance of marbofloxacin has shown significant (P<0.0001) relation with size (Bwt) in various animal species. However, half-life and volume of distribution were not in association with body weight. Although half-life and volume of distribution were not in a good correlation with body weight, statistically significant association between the body clearance and body weight suggests validity of allometric scaling for predicting pharmacokinetic parameters of marbofloxacin in animal species that have not been studied yet. However further study considering large sample size and other parameters influencing pharmacokinetics of marbofloxacin is recommended.

Abo-el-Sooud K, Goudah A (2010) Influence of Pasteurella multocida infection on the pharmacokinetic behavior of marbofloxacin after intravenous and intramuscular administrations in rabbits. J Vet Pharmacol Ther 33: 63-68.

Albarellos G, Montoya L, Landoni M (2005) Pharmacokinetics of marbofloxacin after single intravenous and repeat oral administration to cats. Vet J 170: 222-229.

Boxenbaum H (1980) Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance extrapolation of data to benzodiazepines and phenytoin. J Pharmacokinet Biopharm 8: 165-176.

Bregante MA, Saez P, Aramayona JJ, Fraile L, Garcia MA, Solans C (1999) Comparative pharmacokinetics of enrofloxacin in mice, rats, rabbits, sheep and cows. Am J Vet Res 60: 1111-1116.

Castells G, Capece BP, P´erez F, Mart´ı G, Arboix M, Cristófol C (2001) Allometric analysis of thiamphenicol disposition among seven mammalian species. J Vet Pharmacol Ther 24: 193-197.

Cox SK (2007) Allometric scaling of marbofloxacin, moxifloxacin, danofloxacin and difloxacin pharmacokinetics: a retrospective analysis. J Vet Pharmacol Ther 30: 381-386.

Cox SK, Cottrell MB, Smith L, Papich MG, Frazier DL, Bartges J (2004) Allometric analysis of ciprofloxacin and enrofloxacin pharmacokinetics across species. J Vet Pharmacol Ther 27: 139-146.

Dinev TG (2008) Comparison of the pharmacokinetics of five aminoglycoside and aminocyclitol antibiotics using allometric analysis in mammal and bird species. Res Vet Sci 84: 107-118.

Ding H, Li Y, Chen Z, Rizwan-ul-Haq M, Zeng Z (2010) Plasma and tissue cage fluid pharmacokinetics of marbofloxacin after intravenous, intramuscular, and oral single-dose application in pigs. J Vet Pharmacol Ther 33: 507-510.

Fernandez-Varon E, Carceles CM, Marin P, Martos N, Escudero E, Ayala I (2006) Pharmacokinetics of difloxacin after intravenous, intramuscular and intragastric administration to horses. Am J Vet Res 67: 1076-1081.

Fitton A (1992) The quinolones. An overview of their pharmacology. Clin Pharmacokinet 22: 1-11.

Gonzalez F, Rodr´ıguez C, De Lucas JJ, Waxman S, San Andre´s MD, Serres C, Nieto J, San Andre´s MI (2007) Pharmacokinetics of a single intravenous dose of marbofloxacin in adult donkeys. Vet Rec 161: 133-136.

Haritova AM and Lashev LD (2009) Comparison of the pharmacokinetics of seven fluoroquinolones in mammalian and bird species using allometric analysis. Bulg J Vet Med 12: 3-24.

Ismail M, El-Kattan YA (2007) Comparative pharmacokinetics of marbofloxacin in healthy and Mannheimia haemolytica infected calves. Res Vet Sci 82: 398-404.

Kirkwood JK, Merriam J (1990) Variation in plasma half life of gentamicin between species in relation to body weight and taxonomy. Res Vet Sci 49: 160-165.

Kukanich B, Papich M, Huff D, Stoskopf M (2004) Comparison of amikacin pharmacokinetics in a killer whale (Orcinus orca) and a beluga whale (Delphinapterus leucas). J Zoo Wildl Med 35: 179-184.

Lepiste EI, Jusco WJ (2004) Modeling and allometric scaling of s(+)-ketoprofen pharmacokinetics and pharmacodynamics: a retrospective analysis. J Vet Pharmacol Ther 27: 211-218.

Lin JH, Sugiyama Y, Awazu S, Hanano M (1982) Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtained in vitro as well as on physiological data. J Pharmacokinet Biopharm 10: 649-661.

Mahmood I, Balian JD (1999) The pharmacokinetic principles behind scaling from preclinical results to phase I protocols. Clin Pharmacokinet 36: 1-11.

Martinez M, Mahmood I, Hunter RP (2009) Allometric scaling of clearance in dogs. J Vet Pharmacol Ther 32: 411-416.

Maxwell LK, Jacobson ER (2008) Allometric basis of enrofloxacin scaling in green iguanas. J Vet Pharmacol Ther 31: 9-17.

Riviere JE (1999) Comparative pharmacokinetics: principles, techniques and applications, 2nd ed., Iowa State University Press, Ames.

Riviere JE, Martin-Jimenez T, Sundlof SF, Craigmill AL (1997) Interspecies allometric analysis of the comparative pharmacokinetics of 44 drugs across veterinary and laboratory animal species. J Vet Pharmacol Ther 20: 453-463.

Schneider M, Thomas V, Boisrame B, Deleforge J (1996) Pharmacokinetics of marbofloxacin in dogs after oral and parenteral administration. J Vet Pharmacol Ther 19: 56-61.

Sidhu PK, Landon MF, Aliabadi FS, Lees P (2010) PK-PD integration and modeling of marbofloxacin in sheep. Res Vet Sci 88: 134-141.

Waxman S, Rodrıguez C, Gonzalez F, De Vicente ML, San Andres MI, San Andre´s MD (2001) Pharmacokinetic behavior of marbofloxacin after intravenous and intramuscular administrations in adult goats. J Vet Pharmacol Ther 24: 375-378.

Wiles MD, Hardman JG, Moppett IK (2008) Pharmacokinetic variation. Anaesthesia and Intensive Care Medicine 9: 369-371.

Polish Journal of Veterinary Sciences

The Journal of Committee of Veterinary Sciences of Polish Academy of Sciences and University of Warmia and Mazury in Olsztyn

Journal Information

IMPACT FACTOR 2016: 0.697
5-year IMPACT FACTOR: 0.773

CiteScore 2016: 0.73

SCImago Journal Rank (SJR) 2016: 0.315
Source Normalized Impact per Paper (SNIP) 2016: 0.486


All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 118 69 1
PDF Downloads 79 62 4