Pharmacokinetics of orally administered simvastatin in turkeys

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Abstract

The aim of the present study was to determine the pharmacokinetics of simvastatin (SIM) administered orally in 6-week-old turkeys at a single dose of 2 mg/kg b.w. The SIM concentrations in plasma were determined by validated HPLC-MS/MS method. Mean (± SD; n = 10) values of pharmacokinetic parameters evaluated were as follows: Cmax = 0.49 ± 0.21 ng/ml, tmax = 1.6 ± 1.1 h, AUC(0-∞) = 1.08 ± 0.57 h×ng/ml, t1/2kel = 2.14 ± 1.3 h and MRT = 3.08 ± 1.52 h. The results indicate that the SIM is absorbed from the gastrointestinal tract of turkeys; however, achieved plasma level is lower compared to those observed in mammals.

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Polish Journal of Veterinary Sciences

The Journal of Committee of Veterinary Sciences of Polish Academy of Sciences and University of Warmia and Mazury in Olsztyn

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IMPACT FACTOR 2016: 0.697
5-year IMPACT FACTOR: 0.773

CiteScore 2016: 0.73

SCImago Journal Rank (SJR) 2016: 0.315
Source Normalized Impact per Paper (SNIP) 2016: 0.486

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