The -2518 A/G MCP-1 Polymorphism as a Risk Factor of Inflammatory Bowel Disease

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The -2518 A/G MCP-1 Polymorphism as a Risk Factor of Inflammatory Bowel Disease

Inflammatory bowel diseases (IBD) are disorders originated from immune disturbances.

The aim of the study was to evaluate the association between the -2518 A/G MCP-1 polymorphism and the risk of IBD development.

Material and methods. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Study group consisted of 197 subjects with IBD (120 with ulcerative colitis and 77 with Crohn's disease) as well as 210 healthy controls.

Results. The presence of the -2518 G/G MCP-1 genotype in the investigated groups seems to be connected with higher risk of inflammatory bowel disease as well as Crohn's disease only (OR 2.26; 95% CI 1.44-3.54 and OR 2.08; 95% CI 1.21-3.46, respectively).

Conclusions. Our data showed that the -2518 A/G MCP-1 polymorphism might be associated with the IBD occurrence and might be used as predictive factor of these diseases in a Polish population.

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Polish Journal of Surgery

The Journal of Foundation of the Polish Journal of Surgery

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CiteScore 2016: 0.29

SCImago Journal Rank (SJR) 2016: 0.166
Source Normalized Impact per Paper (SNIP) 2016: 0.207

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