An Association of ARG399GLN Polymorphism of XRCC1 Gene with a Risk of Colorectal Cancer

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An Association of ARG399GLN Polymorphism of XRCC1 Gene with a Risk of Colorectal Cancer

Colorectal cancer is one of the most commonly diagnosed cancer and a leading cause of death from cancer. DNA repair defects have been associated with an individual susceptibility to cancer. Therefore, polymorphisms of DNA repair genes, including XRCC1 gene, are suspected to may increase the risk of colorectal cancer.

The aim of the study was to examine the association between Arg399Gln polymorphisms of XRCC1 gene and the occurrence of colorectal cancer. Research and understanding of the molecular basis of the formation of colorectal cancer will allow for typing of genetically loaded persons and qualifying them to a high-risk group.

Material and methods. In case-control study we genotyped 150 colorectal cancer patients and 170 healthy subjects from Polish population. Analysis was performed by PCR-restriction fragment length polymorphism (PCR-RFLP).

Results. We found that Gln/Gln genotype is associated with increased risk of colorectal cancer (OR 1.984; Cl 95% 1.070-3.677; p=0.029). We also found that Arg/Gln genotype is a risk factor for progression of tumor growth (OR 3.52; Cl 95% 1.157-10.707; p=0.023).

Conclusions. The current state of research suggests a link between Arg399Gln XRCC1 polymorphism and increased risk of colorectal cancer. Therefore, we conclude that the Arg399Gln polymorphism of XRCC1 gene may underlie at the molecular basis of the causes of colorectal cancer.

Abdel-Rahman SZ, Soliman AS, Bondy ML et al.: Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of earlyonset colorectal carcinoma in Egypt. Cancer Lett 2000; 159: 79-86.

Skjelbred CF, Saebo M, Wallin H et al.: Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study. BMC Cancer 2006; 6: 67.

Śliwiński T, Krupa R et al.: No association between the Arg194Trp and Arg399Gln polymorphisms of the XRCC1 gene and colorectal cancer risk and progression in a Polish population. Exp Oncol 2008; 30: 253-54.

Improta G, Sgambato A, Bianchino G et al.: Polymorphisms of the DNA repair genes XRCC1 and XRCC3 and risk of lung and colorectal cancer: a case-control study in a Southern Italian population. Anticancer Res 2008; 28: 2941-46.

Jingwen W, Yang Z, Jing J et al.: Polymorphisms in DNA repair genes XRCC1, XRCC3 and XPD, and colorectal cancer risk: a case - control study in an Indian population. J Cancer Res Clin Oncol 2010; 136: 1517-25.

Nelson HH, Kelsey KT, Mott LA et al.: The XRCC1 Arg399Gln polymorphism, sunburn and non-melanoma skin cancer: evidence of gene-environment interaction. Cancer Res 2002; 62: 152-55.

Zheng J, Chunxiang L, Ye X: A meta-analysis on XRCC1 and XRCC3 polymorphisms and colorectal cancer risk. Int J Colorectal Dis 2010; 25: 169-80.

Misra RR, Ratnasinghe D, Tangrea JA et al.: Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland. Cancer Lett 2003; 91:171-78.

Yeh CC, Hsieh LL, Tang R et al.: MS-920: DNA repair gene polymorphisms, diet and colorectal cancer risk in Taiwan. Cancer Lett 2005; 224: 279-88.

Mort R, Mo L, McEwan C, Melton DW: Lack of involvement of nucleotide excision repair gene polymorphisms in colorectal cancer. Br J Cancer 2003; 89: 333-37.

Polish Journal of Surgery

The Journal of Foundation of the Polish Journal of Surgery

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