The Prognosis for Fetuses with Vein of Galen Malformation and Symptoms of Heart Failure

Open access


Vein of Galen Malformation (VGM) it is the most common cerebral arteriovenus malformation in fetuses and children. Usually VGM causes volume overload of the heart and can induce mass effect in the brain, causing progressive neurological impairment. Modern treatment allow on earlier therapy (before the 5th monthof life). This gives the newborn with isolated VGM and heart failure a chance of survival. This work presents case of isolated vein of Galen malformation with diagnosed cardiomegaly, monophasic flow through the tricuspid valve, large right heart, pericardiac effusion, dilatation of SVC and abnormal doppler exam. Postnatal management included aggressive medical treatment of cardiac failure and early transarterial embolization of the selected vessels feeding the aneurysm at 6 days of age. The newborn is 6 month old, growing normally without neurological deficits or developmental retardation and waiting of next stage therapy. New techniques of treatment give fetuses with VGM and prenatal signs of cardiac insufficiency a chance of survival and healthy life, in a group of selected cases. The analysis of the cardiovascular system in fetuses with VGM according to uniform criteria is essential in order to assess the influence of these malformations on the survivability of newborns.

1. Kośla K Majos M, Polguj M, Antosik-Biernacka A, Stefańczyk L, Majos A. Prenatal diagnosis of a vein of Galen aneurysmal malformation with MR imaging - report of two cases. Pol J Radiol. 2013, 78(4): 88-92.

2. RD Sheth. Vein of Galen Malformation. Medscape. 2015 Nov,

3. Deloison B Chalouhi GE, Sonigo P, Zerah M, Millischer AE, Dumez Y, Brunelle F, Ville Y, Salomon LJ. Hidden mortality of prenatally diagnosed vein of Galen aneurysmal malformation: retrospective study and review of the literature. Ultrasound Obstet Gynecol. 2012, 40: 652-658.

4. Hartung J Heling KS, Rake A, Zimmer C, Chaoui R. Detection of an aneurysm of the vein of Galen following signs of cardiac overload in a 22-week old fetus. Prenat Diagn. 2003 Nov, 23(11):901-3.

5. Lasjaunias PL Chng SM, Sachet M, Alvarez H, Rodesch G, Garcia-Monaco R. The management of vein of Galen aneurysmal malformations. Neurosurgery. 2006 Nov, 59(5 Suppl 3):S184-94; discussion S3-13.

6. Yan J Wen J, Gopaul R, Zhang CY, Xiao SW. Outcome and complications of endovascular embolization for vein of Galen malformations: a systematic review and meta-analysis. J Neurosurg. 2015 Oct, 123(4):872-90.

7. Puvabanditsin S Mehta R, Palomares K, Gengel N, Da Silva CF, Roychowdhury S, Gupta G, Kashyap A, Sorrentino D. Vein of Galen malformation in a neonate: A case report and review of endovascular management. World J Clin Pediatr. 2017 Feb , 8;6(1):103-109.

8. Karadeniz L Coban A, Sencer S, Has R, Ince Z, Can G. Vein of Galen aneurysmal malformation: Prenatal diagnosis and early endovascular management. Journal of the Chinese Medical Association . 2011, 74: 134-137.

9. Statile CJ Cnota JF, Gomien S, Divanovic A, Crombleholme T, Michelfelder E. Estimated cardiac output and cardiovascular profile score in fetuses with high cardiac output lesions. Ultrasound Obstet Gynecol. 2013 Jan, 41(1):54-8.

10. Godfrey ME Tworetzky W, Morash D, Friedman KG. Cardiac Findings in the Fetus with Cerebral Arteriovenous Malformation Are Associated with Adverse Outcome. Fetal Diagn Ther. 2017, 41(2):108-114.

Journal Information


All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 460 460 24
PDF Downloads 109 109 12