Single Fetal Cardiac Tumors and Follow-Up Based on 13 Cases from the Fetal Cardiac Referral Center in 1993-2017

Open access


Introduction: Fetal cardiac tumors are anomalies, that occur rarely: from Nationwide Register of Fetal Cardiological Problems in Poland in years 2004-2016 amongst 8112 fetuses with cardiological problems, there were 85 fetuses with cardiac tumors, including 52 cases of multiple cardiac tumors (0,64%) and 33 of single anomalies (0,4%). Material: This analysis included 13 cases from single tertiary fetal cardiac center Lodz in years 1993-2017. Results: Ten out of 13 fetuses with single cardiac tumors (SFCT) had cardiomegaly: on average HA/CA was 0,49. The size of the tumor was different: the smallest one - 6 x 6 mm, the biggest 47 x 47 mm. The way of the delivery: in 10 cases there was CS and in 3 cases natural delivery. Birth weight was from 2000-3950 g (average 2989,2 g). Cardiosurgical resection of the tumor was performed on 4 newborns: at 2nd, 4th, 8th and 16th day of life (average 7,5 day). Four neonatal deaths were registered (31%): in 1st 2nd and 11th day (before surgery) and in the 28th day after the operation. Conclusions: Single fetal cardiac tumors (SFCT) can be diagnosed at 20 weeks of pregnancy, which allows to start echocardiographic monitoring, taking into consideration the potential risk of hemodynamic progression. SFCT can be the first sign of tuberous sclerosis complex in later prenatal or postnatal life. SFCT other than rhabdomyoma can be asymptomatic in newborn, but may require an early cardiosurgical resection.

1. Qin Y, Wenhua Z, Aiyun Z, Wan Z, Juan L.: Clinical value of prenatal echocardiographic examination in the diagnosis of fetal cardiac tumors. Oncology letters 11: 1555-1559, 2016

2. Shi-Min Y.: Fetal Primary Cardiac Tumors during perinatal period. Pediatric and neonatology 2017, 58 205-210

3. Respondek-Liberska M. Fetal heart tumor. In: Prenatal cardiology for obstetricians and pediatric cardiologists . Czelej , Poland, 247-250, 2006

4. Niewiadomska-Jarosik K, Stanczyk J, Janiak K, Jarosik P, Moll JJ, Zamojska J. et al. Prenatal diagnosis and follow-up of 23 cases of cardiac tumors. Pediatr Cardiol. 2004; 25(3): 252-73

5. Schlaegel F,Takacs Z, Solomayer EF, Abdul-Kaliq H, Meyberg-Solomayer G.: Prenatal diagnosis of giant cardiac rhabdomyoma with fetal hydrops in tuberous sclerosis. Prenatal Medicine 2013; 7(3): 39-41

6. Hansberger LK.: Role of quantative assessment in fetal echocardiography. Ultrasound Obstet Gynecol 35: 4-6, 2010

7. Van Meighem T, DeKoninck P, Steenhaut P and Deprest J: Methods for prenatal assesment of fetal cardiac function. Prenat Diagn 2009: 1193-1203, 209

8. Sokolowski L, Respondek-Liberska M.: The follow up of 114 fetuses and newborns (without chromosomal aberrations) with echogenic intracardiac focus detected in prenatal US. Prenat Cardio 2014 ; 4(2): 6-10

9. Carvalho J, Carrulho M, Tonni G, Araujo Junior E.: Fetal cardiac tumors: prenatal diagnosis and outcomes. Braz J Cardiovasc Surg VI

10. Atallah J, Roberson M, Rebeyka IM, Dyck J, Noga ML. Antenatal diagnosis and successful surgical removal of large right ventricular fibroma. Pediatr Cardiol 2006; 27: 493-6

11. Sydorak RM, Kelly T, Feldstein VA, Sandberg PL, Silverman NH, Harrison MR, et al. Prenatal resection of a fetal pericardial teratoma. Fetal Diagn Therapy 2002; 17: 281-5

12. Carrilho MC, Tonni G, Araujo Junior E.: Fetal cardiac tumors: prenatal diagnsis and outcomes. Rev Bras Cir Cardiovasc 2015; 30: VI-VII

13. Yinon Y, Chitayat D, Blaser S, Seed M, Amsalem H, Yoo SJ, et al. Fetal cardiac tumors: A single-center experience of 40 cases. Prenat Diagn 2010; 30(10):941-9

14. Rychlik J. Open fetal surgery for pericardial teratoma. Available from: Accssed 11 January 2016

15. Paladini D, Tartaglione A, Vassallo M, Martinelli P.: Prenatal ultrasonographic findings of cardiac myxoma. Obset Gynecol 2003; 102:1174-6

16. Zou QC, Fan P, Peng QH, Zhang M, Fu Z, Wang CH. Prenatal echocardiographic differential diagnosis of fetal cardiac tumors. Ultrasound Obstet Gynecol 2004; 23: 165-71

17. Isaacs H Jr.: Fetal and neonatal cardiac tumors. Pediatr Cardiol 2004; 25(3): 252-273

Journal Information


All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 300 300 22
PDF Downloads 106 106 12