The Bacteroides and Parabacteroides species are important obligate anaerobic bacteria that are significant constituents of normal flora (microbiota), and opportunistic pathogens with special biological background. They are highly resistant to antibiotics and monitoring their resistance levels is important for their empiric therapy. Several antibiotic resistance studies were conducted in the USA and Europe and we have data for the region involved in this study showing comparable trends. Multidrug-resistant strains are emerging among Bacteroides too, where the proper antibiotic tests and treatments may be life-saving.
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1. Wexler HM. Bacteroides: the good the bad and the nittygritty. Clin Microbiol Rev. 2007;20(4):593-621.
2. Könönen E Wade WG Citron DM. Bacteroides Porphyromonas Prevotella Fusobacterium and other anaerobic Gram-negative rods. Manual of Clinical Microbiology 10th Edition: American Society of Microbiology; 2011.
3. Nagy E. Anaerobic infections: Update on treatment considerations. Drugs. 2010;70(7):841-58.
4. Sóki J. Extended role for insertion sequence elements in the antibiotic resistance of Bacteroides. World Journal of Clinical Infectious Diseases. 2013;3(1):1-12.
5. Sóki J Wareham DW Rátkai C Aduse-Opoku J Urbán E Nagy E. Prevalence nucleotide sequence and expression studies of two proteins of a 5.6 kb Class III Bacteroides plasmid frequently found in clinical isolates from European countries. Plasmid. 2010;63(2):86-97.
6. Rasmussen BA Bush K Tally FP. Antimicrobial resistance in Bacteroides. Clinical Infectious Diseases. 1993;16:S390-400.
7. Clinical breakpoints [database on the Internet]. European Committee on Antimicrobial Susceptibility Testing (EUCAST). 2015-01. Available from: www.eucast.org/clinical:beakpoints/.
8. Methods for antimicrobial susceptibility testing of anaerobic bacteria Approved Standard Document M11-A8 Clinical Laboratory Standards Institute Wayne PA; 2012.
9. Nagy E Justesen US Eitel Z Urbán E. Development of EUCAST disk diffusion method for susceptibility testing of the Bacteroides fragilis group isolates. Anaerobe. 2015;31:65-71.
10. Nagy E Maier T Urban E Terhes G Kostrzewa M. Species identification of clinical isolates of Bacteroides by matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry. Clinical Microbiology and Infection. 2009;15(8):796-802.
11. Nagy E Becker S Sóki J Urbán E Kostrzewa M. Differentiation of division I (cfiA-negative) and division II (cfiA-positive) Bacteroides fragilis strains by matrix-assisted laser desorption/ionization time of-flight mass spectrometry. Journal of Medical Microbiology. 2011;60(11):1584-90.
12. Johansson Å Nagy E Sóki J. Detection of carbapenemase activities of Bacteroides fragilis strains with matrix-assisted laser desorption ionization – Time of flight mass spectrometry (MALDI-TOF MS). Anaerobe. 2014;26:49-52.
13. Snydman DR Jacobus NV McDermott LA Ruthazer R Golan Y Goldstein EJC et al. National survey on the susceptibility of Bacteroides fragilis group: report and analysis of trends in the United States from 1997-2004. Antimicrobial Agents and Chemotherapy. 2007;51(5):1649-55.
14. Snydman DR Jacobus NV McDermott LA Golan Y Goldstein EJC Harrell L et al. Update on resistance of Bacteroides fragilis group and related species with special attention to carbapenems 2006–2009. Anaerobe. 2011;17(4):147-51.
15. Snydman DR Jacobus NV McDermott LA Golan Y Hecht DW Goldstein EJC et al. Lessons learned from the anaerobe survey: Historical perspective and review of most recent data (2005-2007). Clinical Infectious Diseases. 2010;50(Suppl1):S26-33.
16. Philips I King A Nord CE Hoffstedt B on behalf of the ESCMID Study Group on Antimicrobial Resistance of Anaerobic Bacteria. Antibiotic sensitivity of Bacteroides fragilis group in Europe. European Journal of Clinical Microbiology & Infectious Diseases. 1992;11(4):292-304.
17. Hedberg M Nord CE on behalf of the ESCMID Study Group on Antimicrobial Resistance of Anaerobic Bacteria. Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe. Clinical Microbiology and Infection. 2003;9(6):475-88.
18. Nagy E Urbán E Nord CE on behalf of the ESCMID Study Group on Antimicrobial Resistance of Anaerobic Bacteria. Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe 20 years of experience. Clinical Microbiology and Infection. 2011;17(3):371-9.
19. Labbé A-C Bourgault A-M Vincelette J Turgeon PL Lamothe F. Trends in antimicrobial resistance among clinical isolates of the Bacteroides fragilis group from 1992 to 1997 in Montreal Canada. Antimicrobial Agents and Chemotherapy. 1999;43(10):2517-9.
20. Wybo I Van den Bossche D Soetens O Vekens E Vandoorslaer K Claeys G et al. Fourth Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria. Journal of Antimicrobial Chemotherapy. 2014 January 1 2014;69(1):155-61.
21. Boyanova L Kolarov R Mitov I. Recent evolution of antibiotic resistance in the anaerobes as compared to previous decades. Anaerobe. 2015;31:4-10.
22. Magiorakos AP Srinivasan A Carey RB Carmeli Y Falagas ME Giske CG et al. Multidrug-resistant extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clinical Microbiology and Infection. 2012;18(3):268-81.
23. Hartmeyer GN Sóki J Nagy E Justesen US. Multidrugresistant Bacteroides fragilis group on the rise in Europe? Journal of medical microbiology. 2012 December 1 2012;61(Pt 12):1784-8.
24. Katsandri A Papaparaskevas J Pantazatou A Petrikkos GL Thomopoulos G Houhoula DP et al. Two cases of infections due to multidrug-resistant Bacteroides fragilis group strains. Journal of Clinical Microbiology. 2006 September 1 2006;44(9):3465-7.
25. Urbán E Horváth Z Sóki J Lázár G. First Hungarian case of an infection caused by multidrug-resistant Bacteroides fragilis strain. Anaerobe. 2015;31(0):55-8.
26. Cuchural G. J.; Tally FPJ N. V.; Cleary T.; Finegold S. M.; Hill G.; Iannini P.; O’Keefe P. O.; Pierson C. Comparative activities od newer β-lactam agents against members of the Bacteroides fragilis group. Antimicrobial Agents and Chemotherapy. 1990;34(3):479-80.
27. Snydman DR Jacobus NV McDermott LA. Evaluation of the in vitro activities of doripenem a new broad spectrum carbapenem against recent clinical anaerobic isolates with emphasis on the Bacteroides fragilis group. Antimicrobial Agents and Chemotherapy. 2008(Journal Article).
28. Marina M Ivanova M Kantardjiev T. Antimicrobial susceptibility of anaerobic bacteria in Bulgaria. Anaerobe. 2009;15(4):127-32.
29. Nagy E Szőke I Gacs M Csiszár K. Antibiotic susceptibility of Bacteroides fragilis group strains in Hungary. Anaerobe. 1995 1995/10/01;1(5):269-74.
30. Papaparaskevas J Pantazatou A Katsandri A Legakis NJ Avlamis A. Multicentre survey of the in-vitro activity of seven antimicrobial agents including ertapenem against recently isolated Gram-negative anaerobic bacteria in Greece. Clinical Microbiology and Infection. 2005;11(10):820-4.
31. Papaparaskevas J Pantazatou A Katsandri A Houhoula DP Legakis NJ Tsakris A et al. Moxifloxacin resistance is prevalent among Bacteroides and Prevotella species in Greece. Journal of Antimicrobial Chemotherapy. 2008;62(1):137-41.
32. Grisold AJ Wendelin I Presterl E Raggam RB Masoud L Badura A et al. In vitro activity of ten antibiotics including tigecycline against Bacteroides species in Austria. European Journal of Clinical Microbiology & Infectious Diseases. [journal article]. 2007;26(7):525-7.
33. Novak A Rubic Z Dogas V Goic-Barisic I Radic M Tonkic M. Antimicrobial susceptibility of clinically isolated anaerobic bacteria in a University Hospital Centre Split Croatia in 2013. Anaerobe. 2015;31:31-6.
34. Székely E Eitel Z Molnár S Szász IÉ Bilca D Sóki J. Analysis of Romanian Bacteroides isolates for antibiotic resistance levels and the corresponding antibiotic resistance genes. Anaerobe. 2015;31:11-4.
35. Kierzkowska M Majewska A Sawicka-Grzelak A Mlynarczyk A Chmura A Kwiatkowski A et al. Antibiotic resistance profiles of strictly anaerobic Gram-negative Bacteroides spp. and Parabacteroides spp. bacilli isolated from infected inpatients on surgical wards. Journal of Global Antimicrobial Resistance. 2016;7:128-9.
36. Jeverica S Kolenc U Mueller-Premru M Papst L. Evaluation of the routine antimicrobial susceptibility testing results of clinically significant anaerobic bacteria in a Slovenian tertiary-care hospital in 2015. Anaerobe. 2017;47:64-9.