Pharmacokinetics of Ciprofloxacin in Broiler Chickens After Single Intravenous and Intraingluvial Administration

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Abstract

The trial was performed on 10 clinically healthy Ross hybrid chickens, 5 from each gender, weighing 2.75-2.84 kg. The tested quinolone was applied at the same dose for both routes of application - 10 mg/kg of body weight. Ciprofloxacin hydrochloridum 5% solution for i.v. and 1% solution for intraingluvial treatment were prepared. In a crossover study design, ciprofloxacin hydrochloridum was administered as 5 % solution for i.v. bolus injection to broiler chickens and after 14 days as 1 % solution for intraingluvial administration into a crop to the same birds. Serum ciprofloxacin concentrations were assayed by HPLC with UV detection at a wavelength of 279 nm. After intravenous injection the following pharmacokinetic parameters were determined: t1/2β = 9.07 h; t1/2α= 0.36 h; MRT = 10.20 h and MRT = 10.75 h; AUC0→∞ = 19.560 μg.h/mL and AUC0→∞ = 19.843 μg.h/mL. After intraingluvial application parameters determined by the two pharmacokinetic models were as: t1/2α= 0.86 h; t1/2β = 7,20 h and t1/2β = 7.89 h; MRT = 12.67 h and MRT = 12.93 h; AUC0→∞ = 11.340 μg.h/mL and AUC0→24 h = 11.973 μg.h/mL; Cmax = 2.841 μg/mL and Cmax = 2.638 μg/mL; Tmax = 0.48 h and Tmax = 0.39 h; t1/2abs. = 0.146 h; MAT = 2.47 h and MAT = 2.18 h; F = 57.91% and F = 63.89%. These results suggested that a dose of 10 mg/kg of body weight provides maximum plasma concentration ater intraingluvial administration and is effective in the control of many infectious diseases of poultry.

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  • 1. Hannan P.C.T. O′Hanlon P.J. Rogers N.H. (1989). In vitro evaluation of various quinolone antibacterial agents against veterinary mycoplasmas and porcine respiratory bacterial pathogens. Research in Veterinary Science 46 202−211. PMid:2704885

  • 2. Prescott J. Yielding K.H. (1990). In vitro susceptibility of selected veterinary bacterial pathogens to ciprofloxacin enrofloxacin and norfloxacin. Canadian Journal of Veterinary Research 54 195-197.

  • 3. Neer T.M. (1988). Clinical pharmacologic features of fluoroquinolone antimicrobial drugs. Journal of American Veterinary Medical Association 193 577-580.

  • 4. Vancustem P.M. Babish J.G. Schwark W.S. (1990). The fluoroquinolone antimicrobials clinical use in domestic animals and toxicity. Cornell Veterinarian 80 173-186.

  • 5. Gellert M. (1981). DNA topoisomerases. Annual Reviews of Biochemistry 50 879-910. https://doi.org/10.1146/annurev.bi.50.070181.004311 PMid:6267993

  • 6. Nouws J.F.M. Mevius D.J. Vree T.B. Baars A.M. Laurensen J. (1988). Pharmacokinetics renal clearance and metabolism of ciprofloxacin following intravenous and oral administration to calves and pigs. Veterinary Quarterly 10 156-163. https://doi.org/10.1080/01652176.1988.9694165 PMid:3176294

  • 7. Walker R.D. Stein G.E. Hauptman J.G. MacDonald K.H. Budsberg S.C. Rosser E.J.Jr. (1990). Serum and tissue cage fluid concentrations of ciprofloxacin after oral administration of the drug to healthy dogs. American Journal of Veterinary Research 51 896-900.

  • 8. Parikh V. Shivprakash K. Patel D. Gandhi T.P. Patel R.B. Santani D.D. (1996). Effect of aspirin on single and multiple dose pharmacokinetics of ciprofloxacin in rabbits. Indian Journal of Pharmacology 28 (10): 25-28.

  • 9. Atta A.H. Sharif L. (1997). Pharmacokinetics of ciprofloxacin folowing intravenous and oral administration in broiler chickens. Journal of Veterinary Pharmacology and Therapeutics 20 326-329. https://doi.org/10.1046/j.1365-2885.1997.00065.x

  • 10. Nouaille-Degorce B. Veau C. Dautrey S. Tod M. Laouari D. Carbon C. Farinotti R. (1998). Influence of renal failure on ciprofloxacin pharmacokinetics in rats. Antimicrobial Agents and Chemotherapy 42 289-292.

  • 11. García Ovando H. Gorla N. Luders C. Poloni G. Errecalde C. Prieto G. Puelles I. (1999). Comparative pharmacokinetics of enrofloxacin and ciprofloxacin in chickens. Journal of Veterinary Pharmacology and Therapeutics 22 209-212. https://doi.org/10.1046/j.1365-2885.1999.00211.x

  • 12. Anadón A. Martínez-Larraňaga M.R. Iturbe J. Martínez M.A. Díaz M.J. Frejo M.T. Martínez M. (2001). Pharmacokinetics and residues of ciprofloxacin and its metabolites in broiler chickens. Research in Veterinary Science 71 101-109. https://doi.org/10.1053/rvsc.2001.0494 PMid:11883887

  • 13. Bashir S. (2007). Pharmacokinetics of Ciprofloxacin in Normal and Different Metabolically Altered Conditions in Rabbits PhD Thesis University College of Pharmacy University of the Punjab Lahore Pakistan.

  • 14. Siefert H.M. Maruhn D. Maul W. Förster D. Ritter W. (1986). Pharmacokinetics of ciprofloxacin. Arzneimittelforschung Drug Research 36 1496-1502.

  • 15. Imre S. Dogaru M.T. Vari C.E. Muntean T. Kelemen L. (2003). Validation of an HPLC method for the determination of ciprofloxacin in human plasma. Journal of Pharmaceutical and Biomedical Analysis 33 125-130. https://doi.org/10.1016/S0731-7085(03 00151-1

  • 16. Heinzel G. Wolszcak R. Tomann P. (1993). TopFit®2.0. Pharmacokinetic and pharmacodynamic data analysis for the PC. Gustav Fisher Verlag Stuttgart Germany.

  • 17. Gibaldi M. Perrier D. (2007). Noncompartimental analysis based on the statistical moment theory. In: Gibaldi M Perrier D (Eds). Pharmacokinetics (pp. 409-419) 2nd ed. Revised and Expanded Informa Healthcare Inc. New York USA.

  • 18. Yamaoka K. Nakagava T. Uno T. (1978). Application of Akaike¢s information criterion (AIC) in the evaluation of linear pharmacokinetic equations. Journal of Pharmacokinetics and Biopharmaceutics 6 166-171. https://doi.org/10.1007/BF01117450

  • 19. Raina R. Prawez S. Dimitrova D.J. Verma P.K. Pankaj N.K. (2007a). Pharmacokinetics of ciprofloxacin following intravenous administration in WLH chikens (Gallus domesticus). Journal of Veterinary Pharmacology and Toxicology 6 6-11.

  • 20. Raina R. Prawez S. Pankaj N.K. Verma P.K. (2007b). Pharmacokinetics of ciprofloxacin after single oral administration to WLH chicken (Gallus domesticus). Tamilnadu Journal of Veterinary and Animal Sciences 3 254-259.

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