Canine Mammary Tumours - Clinical Survey

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Mammary tumours are the second most frequent neoplasia in dogs, mainly affecting older female patients. Approximately 50% of the mammary tumours are malignant with high percentage of mortality, if not treated in time. The aim of this study was to analyze the data of canine patients with mammary tumours, to evaluate the type of tumours, as well as the relationship between tumour incidence and dogs’ age, reproductive cycle and sterilization. The survey was used to retrieve the information in the period of two years from the patient data base of the University Veterinary Hospital at the Faculty of veterinary medicine in Skopje. Patients included in this survey were subjected to routine clinical investigation and additional laboratory tests (cytological examination, x-rays imaging, CBC and biochemical profile, histopathology of the tumor samples). Aged female patients (12 - 13 years) are the most susceptible category for development of mammary tumours. The reproductive history showed that five of the patients with malignant mammary tumours have never whelped and were not treated with any exogenous hormones. Malignant tumours (adenocarcinoma) were diagnosed in 90% of the patients. Three patients died due to lung metastasis. Late diagnosis is one of the major problems that results in lethal outcome due to lung metastases. Since ovarian steroids play an important role in the aetiology, the most effective prevention of mammary tumours is elective ovariectomy of the bitch at an early age.

1. Moulton, J.E. (1990). Tumours of the mammary gland. In Moulton J.E. (Ed.), Tumours in Domestic Animals, (pp 518-552). Berkeley: University of California Press.

2. Sorenmo K. (2003). Canine mammary gland tumors. Vet Clin North Am Small Anim Pract. 33, 573-596.

3. Perez, A., Pena, L., Del Castillo, N., Nieto A.I. (2000). Factors influencing the incidence and prognosis of canine mammary tumours. J Small Anim Pract. 41, 287-291.

4. Sorenmo, K.U., Kristiansen, V.M., Cofone, M.A., Shofer, F.S., Breen, A.M., Langeland, M., Mongil, C.M., Grondahl, A.M., Teige, J., Goldschmidt, M.H. (2009). Canine mammary gland tumours; a histological continuum from benign to malignant; clinical and histopathological evidence. Vet Comp Oncol. 7, 162-172. PMid:19691645

5. Rutteman, G. R. (1990). Hormones and mammary tumour disease in the female dog: an update. In vivo. 4, 33-40. PMid:2103839

6. Misdorp, W. (2002). Tumours of the mammary gland. In: Meuten D.J. (Ed.), Tumours in Domestic Animals, (pp. 575-606). Ames: Iowa State Press.

7. MacEwen, E.G., Withrow, S. (1996). Tumours of the mammary gland. Small Animal Oncology. (pp. 356-372) Philadelphia: Saunders Company.

8. Lana, S.E., Rutteman, G.R., Withrow, S.J. (2007). v Tumours of the mammary gland. In: Withrow S.J. & MacEwen B.R. (Ed.), Small Animal Clinical Oncology, (pp 455-477). Philadelphia: Saunders Company.

9. Murphy, S. (2008). Mammary tumours in dogs and cats. In practice. 6, 334-339.

10. Withrow, S. J.,Vail, D. M. (2007). Small animal clinical oncology. Fourth edition, (pp 619-636). Saunders Elsevier.

11. Misdorp, W., Hellmen, E., Else, R.W. (1999). Mammary Tumours and dysplasia in dogs and cats. Histologic classification of tumours of domestic animals. Second series (pp 3-6). Washington, DC: Armed Forces Institute of Pathology.

12. Zatloukal, J., Lorenzová, J., Tichy, F., Nečas, A., Kecová, H., Kohout, P. (2005). Breed and age as risk factors for canine mammary tumours. Acto Vet Brno. 74, 103-109.

13. Sorenmo, K.U., Shoferm, F.S., Goldschmidt, M.H. (2000). Effect of spaying and timing of spaying on survival of dogs with mammary carcinoma. J Vet Intern Med. 14, 266-270. PMid:10830539

14. Queiroga, F.L., Perez- Alenza, M.D., Silvan, G., Pena, L., Lopes, C., Illera, J.C. (2005). Role of steroid hormones and prolactin in canine mammary cancer. J Steroid Biochem Mol Biol. 94, 181-187. PMid:15862964

15. Schneider, R., Dorn, C.R., Taylor, D.O. (1969). Factors influencing canine mammary cancer development and postsurgical survival. J Natl Cancer Inst. 43, 1249-1261. PMid:4319248

16. Stovring, M., Moe, L., Glattre, E. (1997). A populationbased case-control study of canine mammary tumours and clinical use of medroxyprogesterone acetate. APMIS. 105, 590-596. PMid:9298095

17. Chang, S.C., Chang, C.C., Chang, T.J., Wong, M.L. (2005). Prognostic factors associated with survival two years after surgery in dogs with malignant mammary tumours: 79 cases (1998-2002). J Am Vet Med Assoc. 227, 1625-1629. PMid:16313041

18. Sontasa, B.H., Ozyogurtcub, H., Gurelb, A., Ekicia, H. (2009). Evaluation of clinical and pathological characteristics of 155 canines with mammary tumours: a retrospective study. Arch Med Vet. 41, 53-59.

19. Benjamin, S.A., Lee, A.C., Saunders, W.J. (1999). Classification and behavior of canine mammary epithelial neoplasms based on life-span observations in beagles. Vet Pathol. 36, 423-436. PMid:10490210

20. Ežerskytė, A., Zamokas, G., Grigonis, A., Juodžiukynienė, N. (2011). The retrospective analyses of mammary tumours in dogs. ISSN 1392-2130. Vet Med Zoot. 53 (75), 3-8.

21. Fossum, T.W., Hedlund, C.S. (1997). Mammary neoplasia. In Duncan L. (Ed.), Small Animal Surgey (pp. 539-544). St-Louis: Don Ladig.

22. Straw, R.C. (2005). Treatment of mammary gland tumours and perianal neoplasia. The North American Veterinary Conference (NAVC). Orlando, Florida.

23. Moe, L. (2001). Population-based incidence of mammary tumours in some dog breeds. J Reprod Fertil Suppl. 57, 439-43. PMid:11787188

24. Stratmann, N., Failing, K., Richter, A., Wehrend, A. (2008). Mammary tumour recurrence in bitches after regional mastectomy. Vet Surg. 37, 82-86. PMid:18199060

25. Sleeckx, N., de Rooster, H., Veldhuis Kroeze, E.J.B., Van Ginneken, C., Van Brantegem, L. (2011). Canine mammary tumours, an overview. Reprod Dom Anim. 46, 1112-1131.

Macedonian Veterinary Review

The Journal of the Faculty of Veterinary Medicine-Skopje at the Ss. Cyril and Methodius University in Skopje

Journal Information

CiteScore 2017: 0.32

SCImago Journal Rank (SJR) 2017: 0.195
Source Normalized Impact per Paper (SNIP) 2017: 0.387


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