Synthesis of Some New Thiazolidine Derivatives and Their Biological Significance

Open access

Synthesis of Some New Thiazolidine Derivatives and Their Biological Significance

An efficient route for the synthesis of new series of N-[3-(1H-1,2,3-benzotriazol-1-yl)-propyl]-2-(substituted phenyl)-4-oxo-5-(substituted benzylidene)-1,3-thiazolidine carboxamide, compounds 5 (a-j) has been elaborated. The compounds 5 (a-j) have been synthesized and characterized by IR, 1H NMR, 13C NMR, FAB Mass spectra and chemical analysis. All final compounds were screened for their antimicrobial activity against some selected bacteria, fungi, antituberculosis (against M. tuberculosis) and antiinflammatory activity on albino rats.

Upadhyay, A., Srivastava, S. K., Srivastava, S. D. (2010). Conventional and microwave assisted synthesis of some new N-[(4-oxo-2-substituted aryl-1,3-thiazolidine)acetamide]-5-nitroindazoles. Eur. J. Med. Chem., 45, 3541-3548.

Sayyed, M., Mokle, S., Bokhare, M., Mankar, A., Surwase, S., Bhusare, S., Vibhute, Y. (2006). Synthesis of some new 2,3-diaryl-1,3-thiazolidin-4-ones as antibacterial agents. Arkivoc, 2, 187-192.

Mulwad, V. V., Mir, A. A. (2008). Synthesis and antibacterial screening of N-[coumarin-6-yl]spiroindoloazetidin-2-ones/thiazolidin-4-ones. J. Korean Chem. Soc., 52 (6), 649-656.

Dua, R., Srivastava, S. K., Srivastava, S. D. (2009). Synthesis, characterization and anti-microbial activity of 4-oxothiazolidines and 5-arylidene derivatives of 2-methylimidazoles. Macroheterocycles, 2 (5), 271-274.

Yadav, R., Srivastava, S. D., Srivastava, S. K. (2005). Synthesis, antimicrobial and anti-inflammatory activities of 4-oxothiazolidines and their 5-arylidenes. Indian J. Chem., 44B, 1262-1266.

Terzioglu, N., Karalı, N., Gursoy, A., Pannecouque, C., Leysen, P., Paeshuyse, J., Neyts, J., Clercq, E. De. (2006). Synthesis and primary antiviral activity evaluation of 3-hydrazono-5-nitro-2-indolinone derivatives. Arkivoc, 1, 109-118.

Visagaperumal, D., Kumar, R. J., Vijayaraj, R., Anbalagan, N. (2009). Microwave-induced synthesis of some new 3-substituted-1, 3-thiazolidin-4-ones for their potent antimicrobial and antitubercular activities. Int. J. Chem. Tech. Res., 4, 1048-1051.

Lu, Y., Wang, Z., Li, C.-M., Chen, J., Dalton, J. T., Li, W., Miller, D. D. (2010). Synthesis, in vitro structure-activity relationship, and in vivo studies of 2-arylthiazolidine-4-carboxylic acid amides as anticancer agents. Bioorg. Med. Chem., 18 (2), 477-495.

Holmes, D. S., Bethell, R. C., Hann, M. M., Kitchin, J., Starkey, I. D., Storer, R. (1993). The design and synthesis of novel hydroxyproline inhibitors of HIV-1 proteinase. Bioorg. Med. Chem. Lett., 3 (8), 1485-1491.

Dixit, P. P., Nair, P. S., Patil, V. J., Jain, S., Arora, S. K., Sinha, N. (2005). Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives. Bioorg. Med. Chem. Lett., 15, 3002-3005.

Vora, J. J., Vasava, S. B., Patel, A. D., Parmar, K. C., Chauhan, S. K., Sharma, S. S. (2009). Synthesis, Characterization and Antibacterial Activity of a New Series of s-Triazines Derived with Quinolines. Eur. J. Chem., 6 (1), 201-206.

Barbaric, M., Kralj, M., Marjanovic, M., Husnjak, I., Pavelic, K., Filipovic-Grcic, J., Zorc, D., Zorc, B. (2007). Synthesis and in vitro antitumor effect of diclofenac and fenoprofen thiolated and nonthiolated polyaspartamide-drug conjugates. Eur. J. Med. Chem., 42, 20-29.

Rezaei, Z., Khabnadideh, S., Pakshir, K., Hossaini, Z., Amiri, F., Assadpour, E. (2009). Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives. Eur. J. Med. Chem., 44, 3064-3067.

Patel, P. D., Patel, M. R., Kocsis, B., Kocsis, E., Graham, S. M., Warren, A. R., Nicholson, S. M., Billack, B., Fronczek, F. R., Talele, T. T. (2010). Design, synthesis and determination of antifungal activity of 5(6)-substituted benzotriazoles. Eur. J. Med. Chem., 45, 2214-2222.

Kumar, G. V. S., Rajendraprasad, Y., Mallikarjuna, B. P., Chandrashekar, S. M., Kistayya, C. (2010). Synthesis of some novel 2-substituted 5-[isopropylthiazole]-clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents. Eur. J. Med. Chem., 45, 2063-2074.

Rajasekaran, A., Rajagopal, K. A. (2009). Synthesis of some novel triazole derivatives as antinociceptive and antiinflammatory agents. Acta Pharm., 59, 355-364.

Latvian Journal of Chemistry

The Journal of Riga Technical University

Journal Information

Metrics

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 378 336 19
PDF Downloads 139 129 8