Occurrence and distribution of canine cutaneous mast cell tumour characteristics among predisposed breeds

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Introduction: Breed predisposition to cutaneous mast cell tumours (MCT) in a population of dogs in Poland affected by various skin tumours was assessed, and the distribution of MCT characteristics such as histological grading, sex, age, and location, in predisposed breeds was evaluated.

Material and Methods: The retrospective epidemiological study included 550 dogs affected by cutaneous MCTs with a reference group of 2,557 dogs diagnosed with other skin tumours.

Results: A univariable logistic regression analysis was performed to determine the odds ratios (ORs) with 95% confidence intervals. The risk of high-grade MCTs was the highest for Shar-Peis (OR: 26.394) and American Staffordshire Terriers (OR: 2.897). Boxers (OR: 6.619), Labrador Retrievers (OR: 2.630), French Bulldogs (OR: 2.050), Golden Retrievers (OR: 1.949), and American Staffordshire Terriers (OR: 2.592) were mainly affected by low-grade MCTs. The high risk of MCT was calculated to be at the age of 4–6 years for Labrador Retrievers (OR: 2.686) and 7–10 years for Boxers (OR: 2.956) and French Bulldogs (OR: 9.429). MCTs were significantly more often located on the trunk in French Bulldogs (OR: 4.680), American Staffordshire Terriers (OR: 2.520), and Labrador Retrievers (OR: 1.948). There was no statistically significant correlation between gender and the occurrence of MCTs in the breeds.

Conclusions: The breed-predicated differences in the clinical course of MCTs suggest a genetic background for the tumours.

1. Adams V.J., Evans K.M., Sampson J., Wood J.L.: Methods and mortality results of a health survey of purebred dogs in the UK. J Small Anim Pract 2010, 51, 512–524.

2. Arendt M.L., Melin M., Tonomura N., Koltookian M., Courtay-Cahen C., Flindall N., Bass J., Boerkamp K., Megquir K., Youell L., Murphy S., McCarthy C., London C., Rutteman G.R., Starkey M., Lindblad-Toh K.: Genome-wide association study of Golden Retrievers identifies germ-line risk factors predisposing to mast cell tumours. PLoS Genet 2015, 11, e1005647.

3. Blackwood L., Murphy S., Buracco P., de Vos J.P., de Fornel-Thibaud P., Hirschberger J., Kessler M., Pastor J., Ponce F., Savary-Bataille K., Argyle D.J.: European consensus document on mast cell tumours in dogs and cats. Vet Comp Oncol 2012, 10, e1–e29.

4. Boerkamp K.M., Teske E., Boon L.R., Grinwis G.C., van den Bossche L., Rutteman G.R.: Estimated incidence rate and distribution of tumours in 4,653 cases of archival submissions derived from the Dutch golden retriever population. BMC Vet Res 2014, 31, 10–34.

5. Davis B.W., Ostrander E.A.: Domestic dogs and cancer research: a breed-based genomics approach. ILAR J 2014, 55, 59–68.

6. Dobson J.M.: Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013, ID: 941275, doi:10.1155/2013/941275.

7. Dobson J.M., Scase T.J.: Advances in the diagnosis and management of cutaneous mast cell tumours in dogs. J Small Anim Pract 2007, 48, 424–431.

8. Egenvall A., Bonnett B.N., Hedhammar A., Olson P.: Mortality in over 350,000 insured Swedish dogs from 1995–2000: II. Breed-specific age and survival patterns and relative risk for causes of death. Acta Vet Scand 2005, 46, 121–136.

9. Erich S.A., Constantino-Casas F., Dobson J.M., Teske E.: Morphological distinction of histiocytic sarcoma from other tumor types in Bernese Mountain Dogs and Flatcoated Retrievers. In Vivo 2018, 32, 7–17.

10. Grüntzig K., Graf R., Boo G., Guscetti F., Hässig M., Axhausen K.W., Fabrikant S., Welle M., Meier D., Folkers G., Pospischil A.: Swiss Canine Cancer Registry 1955–2008: occurrence of the most common tumour diagnoses and influence of age, breed, body size, sex, and neutering status on tumour development. J Comp Pathol 2016, 155, 156–170.

11. Grüntzig K., Graf R., Hassig M., Welle M., Meier D., Lott G., Erni D., Schenker N.S., Guscetti F., Boo G., Axhausen K., Fabrikant S., Folkers G., Pospischil A.: The Swiss Canine Cancer Registry: a retrospective study on the occurrence of tumours in dogs in Switzerland from 1955 to 2008. J Comp Pathol 2015, 152, 161–171.

12. Kandefer-Gola M., Nowak M., Madej J.A., Dzimira S., Ciaputa R., Janus I.: Useful immunohistochemical indicators in canine mast cell tumours Act Vet Hung 2015, 63, 49–59.

13. Kandefer-Gola M., Nowak M., Dzimira S., Janus I., Ciaputa R., Madej J.A.: COX-2 and mPGES-1 expression in canine mast cell tumour. Med Weter 2015 71, 345–348.

14. Kandefer-Gola M., Madej J.A., Dzimira S., Nowak M., Janus I., Ciaputa R.: Comparative analysis of markers of cell proliferation in canine mast cell tumour according to current classifications. Pol J Vet Sci 2015, 18, 241–247.

15. Kandefer-Gola M., Madej J.A., Dzimira S., Janus I., Nowak M., Ciaputa R.: Immunohistochemical evaluation of neoangiogenesis in canine mast cell tumours. Bull Vet Inst Pulawy 2015, 59, 247–253.

16. Kiupel M., Webster J.D., Bailey K.L., Best S., DeLay J., Detrisac C.J., Fitzgerald S.D., Gamble D., Ginn P.E., Goldschmidt M.H., Hendrick M.J., Howerth E.W., Janovitz E.B., Langohr I., Lenz S.D., Lipscomb T.P., Miller M.A., Misdorp W., Moroff S., Mullaney T.P., Neyens I., O’Toole D., Ramos-Vara J., Scase T.J., Schulman F.Y., Sledge D., Smedley R.C., Smith K., Snyder P., Southorn E., Stedman N.L., Steficek B.A., Stromberg P.C., Valli V.E., Weisbrode S.E., Yager J., Heller J., Miller R.: Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior. Vet Pathol 2011, 48, 147–155.

17. Krupa A., Hildebrand W., Kandefer-Gola M., Nowak M., Nicpoń J.: Mast cell tumor. Med Weter 2013, 69, 102–108.

18. Leidinger E.F., Freeman K., Kirtz G., Hooijberg E.H., Sick K.: Breed related odds ratio and anatomic distribution of canine mast cell tumours in Austria. Retrospective study of cases in the years 2000–2010. Tierarztl Prax Ausg K Kleintiere Heimtiere 2014, 42, 367–373.

19. Miller D.M.: The occurrence of mast cell tumors in young Shar-Peis. J Vet Diagn Invest 1995, 7, 360–363.

20. Mochizuki H., Motsinger-Reif A., Bettini C., Moroff S., Breen M.: Association of breed and histopathological grade in canine mast cell tumours. Vet Comp Oncol 2017, 15, 829–839.

21. O’Connell K., Thomson M.: Evaluation of prognostic indicators in dogs with multiple, simultaneously occurring cutaneous mast cell tumours: 63 cases. Vet Comp Oncol 2013, 11, 51–62.

22. O’Neill D.G., Church D.B., McGreevy P.D., Thomson P.C., Brodbelt D.C.: Longevity and mortality of owned dogs in England. Vet J 2013, 198, 638–643.

23. Olson K.R., Levy J.K., Norby B., Crandall M.M., Broadhurst J.E., Jacks S., Barton R.C., Zimmerman M.S.: Inconsistent identification of pit bull-type dogs by shelter staff. Vet J 2015, 206, 197–202.

24. Patnaik A.K., Ehler W.J., MacEwen E.G.: Canine cutaneous mast cell tumor: morphologic grading and survival time in 83 dogs. Vet Pathol 1984, 21, 469–474.

25. Pizzoni S., Sabattini S., Stefanello D., Dentini A., Ferrari R., Dacasto M., Giantin M., Laganga P., Amati M., Tortorella G., Marconato L.: Features and prognostic impact of distant metastases in 45 dogs with de novo stage IV cutaneous mast cell tumours: A prospective study. Vet Comp Oncol 2017, 16, 28–36.

26. Polton G.A., Mowat V., Lee H.C., McKee K.A., Scase T.J.: Breed, gender and neutering status of British dogs with anal sac gland carcinoma. Vet Comp Oncol 2006, 4, 125–131.

27. Shoop S.J., Marlow S., Church D.B., English K., McGreevy P.D., Stell A.J., Thomson P.C., O’Neill D.G., Brodbelt D.C.: Prevalence and risk factors for mast cell tumours in dogs in England. Canine Genet Epidemiol 2015, 2, 1–10.

28. Sledge D.G., Webster J., Kiupel M.: Canine cutaneous mast cell tumors: A combined clinical and pathologic approach to diagnosis, prognosis and treatment selection. Vet J 2016, 215, 43–54.

29. Śmiech A., Ślaska B., Łopuszyński W., Jasik A., Szczepanik M., Wilkołek P.: Epidemiological study of canine mast cell tumours according to the histological malignancy grade. Pol J Vet Sci 2017, 20, 455–465.

30. Śmiech A., Ślaska B., Surdyka M., Grzybowska-Szatkowska L., Łopuszyński W., Różańska D.: Identification of additional mitochondrial DNA mutations in canine mast cell tumours. Acta Vet Scand 2016, 58, 2–8.

31. Villamil J.A., Henry C.J., Bryan J.N., Ellersieck M., Schultz L., Tyler J.W., Hahn A.W.: Identification of the most common cutaneous neoplasms in dogs and evaluation of breed and age distributions for selected neoplasms. J Am Vet Med Assoc 2011, 239, 960–965.

32. Warland J., Dobson J.: Breed predispositions in canine mast cell tumour: a single centre experience in the United Kingdom. Vet J 2013, 197, 496–498.

33. Welle M.M., Bley C.R., Howard J., Rüfenacht S.: Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment. Vet Dermatol 2008, 19, 321–339.

34. White C.R., Hohenhaus A.E., Kelsey J., Procter-Gray E.: Cutaneous MCTs: associations with spay/neuter status, breed, body size, and phylogenetic cluster. J Am Anim Hosp Assoc 2011, 47, 210–216.

35. Zinc M.C., Farhoody P., Elser S.E., Ruffini L.D., Gibbons T.A., Rieger R.H.: Evaluation of the risk and age of onset of cancer and behavioral disorders in gonadectomized Vizslas. J Am Vet Med Assoc 2014, 244, 309–319.

Journal of Veterinary Research

formerly Bulletin of the Veterinary Institute in Pulawy

Journal Information

IMPACT FACTOR J Vet Res 2017: 0.811

CiteScore 2017: 0.68

SCImago Journal Rank (SJR) 2017: 0.29
Source Normalized Impact per Paper (SNIP) 2017: 0.484


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