Analysis of haematological and biochemical blood parameters after electrical cardioversion of atrial fibrillation in dogs

Open access

Abstract

Introduction: Electrical cardioversion is a therapeutic procedure used to convert various types of arrhythmias back to sinus rhythm. It is used to restore the sinus rhythm in dogs with atrial fibrillation. The effect of the electrical energy used during cardioversion on red blood cells (RBC) is not fully understood. Studies on humans reported lysis of RBC following electrical cardioversion. Similar studies have not been carried out on dogs. The aim of the study was to assess the effect of electrical cardioversion on chosen RBC parameters.

Material and Methods: The study was carried out on 14 large and giant breed dogs weighing from 30 to 84 kg with lone atrial fibrillation (lone AF). Electrical cardioversion was carried out under general anaesthesia by biphasic shock with 70–360 J of energy. Blood was collected at T0 – during atrial fibrillation, prior to cardioversion, and at T1 – 30 min after electrical cardioversion. Complete blood counts as well as total and direct bilirubin concentrations were evaluated. A maximum output of 360 J was used.

Results: In all cases, electrical cardioversion was effective, and no significant changes in the number of RBC and RBC indices were noted. Similarly, there were no statistically significant differences in the levels of total and direct bilirubin.

Conclusion: Electrical cardioversion in dogs led neither to statistically nor clinically significant RBC lysis.

1. Bennett M., Horton S., Thuys C., Augustin S., Rosenberg M., Brizard C.: Pump-induced haemolysis: a comparison of short-term ventricular assist devices. Perfusion 2004, 19, 107–111.

2. Cemin R., Rauhe W., Marini M., Pescoller F., Pitscheider W.: Serum troponin I level after external electrical direct current synchronized cardioversion in patients with normal or reduced ejection fraction: no evidence of myocytes injury. Clin Cardiol 2005, 28, 467–470.

3. Cepiel A., Noszczyk-Nowak A., Pasławski R., Janiszewski A., Pasławska U.: Intracardiac electrophysiological conduction parameters in adult dogs. Vet Quarterly 2017, 37, 91–97.

4. Gajek J., Zyśko D., Mysiak A., Mazurek W.: Activation of generalised inflammatory reaction following electrical cardioversion. Kardiol Pol 2004, 61, 225–231.

5. Geraets D.R., Kienzle M.G.: Atrial fibrillation and atrial flutter. Clin Pharm 1993, 12, 721–735.

6. Grubb N.R., Cuthbert D., Cawood P., Flapan A.D., Fox K.A.: Effect of DC shock on serum levels of total creatine kinase, MB-creatine kinase mass, and troponin T. Resuscitation 1998, 36, 193–199.

7. Kosior D.A., Opolski G., Tadeusiak W., Chwyczko T., Wozakowska-Kaplon B., Stawicki S., Filipak K.J., Rabczenko D.: Serum troponin I and myoglobin after monophasic versus biphasic transthoracic shocks for cardioversion of persistent atrial fibrillation. Pacing Clin Electrophysiol 2005, 28, 128–132.

8. Madden J.L., Drakos S.G., Stehlik J., McKellar S.H., Rondina M.T., Weyrich A.S., Selzman C.H.: Baseline red blood cell osmotic fragility does not predict the degree of post-LVAD hemolysis. ASAIO J 2014, 60, 524–528.

9. Makowski M., Bissinger A.B., Fic A., Szymanska K., Sewczyk M., Lubinski A., Baj Z.: Impact of electrical cardioversion for atrial fibrillation on erythrocytes. Eur J Heart Fail Abstracts Supplement 2015, 17, 399–400.

10. Mamikonian L.S., Mamo L.B., Smith P.B., Koo J., Lodge A.J., Turi J.L.: Cardiopulmonary bypass is associated with hemolysis and acute kidney injury in neonates, infants, and children. Pediatr Crit Care Med 2014, 15, 111–119.

11. Maraj R., Jacobs L.E., Ioli A., Kotler M.N.: Evaluation of hemolysis in patients with prosthetic heart valves. Clin Cardiol 1998, 21, 387–392.

12. Moroz V.V., Bogushevich M.S., Chernysh A.M., Kozlova E.K., Sharakshane A.S.: Effect of defibrillation pulses of different shapes on biomembranes: experimental study. Bull Exp Biol Med 2004, 137, 120–123.

13. Noszczyk-Nowak A., Michałek M., Kałuża E., Cepiel A., Pasławska U.: Prevalence of arrhythmias in dogs examined between 2008 and 2014. J Vet Res 2017, 61, 103–110.

14. Noszczyk-Nowak A., Pasławska U., Zyśko D., Gajek J., Nicpoń J., Hebel M.: Atrial fibrillation in dogs. Med Weter 2008, 64, 686–689.

15. Noszczyk-Nowak A., Skoczyński P., Gajek J.: Tachycardio-myopathy in humans and animals – pathophysiology, treatment, and prognosis. Adv Clin Exp Med 2010, 19, 245–249.

16. Palanzo D.A., El-Banayosy A., Stephenson E., Brehm C., Kunselman A., Pae W.E.: Comparison of hemolysis between CentriMag and RotaFlow rotary blood pumps during extracorporeal membrane oxygenation. Artif Organs 2013, 37, 162–166.

17. Qin M., Li L., Liu X., Liu T., Shi S.B.: Neural substrate of posterior left atrium: a novel modulation for inducibility and remodeling of atrial fibrillation in canine. PLoS One 2017, 12:e0176626.

18. Tai C.T., Lo L.W., Lin Y.J., Chen S.A.: Arrhythmogenic difference between the left and right atria in a canine ventricular pacing-induced heart failure model of atrial fibrillation. Pacing Clin Electrophysiol 2012, 35, 188–195.

Journal of Veterinary Research

formerly Bulletin of the Veterinary Institute in Pulawy

Journal Information


IMPACT FACTOR J Vet Res 2017: 0.811

CiteScore 2017: 0.68

SCImago Journal Rank (SJR) 2017: 0.29
Source Normalized Impact per Paper (SNIP) 2017: 0.484

Metrics

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 180 180 25
PDF Downloads 95 95 17