Kidney Damage in Autoimmune Diseases

Open access

Kidney Damage in Autoimmune Diseases

Renal involvement in autoimmunity has many facets. Glomerular, tubular and vascular structures are targeted and damaged as a consequence of autoimmune processes. Immunologically mediated kidney diseases represent the third most common cause of end-stage renal failure (after diabetic and hypertensive nephropathies). Appropriate evalution of patients with immune-mediated kidney diseases requires a meticulous history and physical examination, with particular attention to the urinalysis, tests of renal function and often renal biopsy. The thorough clinician should personally review microscopic urinalysis in any case in which there is a reasonable index of suspicion of immune-mediated renal disease. In this article we propose to highlight recent developments, with particular reference to renal autoimmunity. Systemic lupus erythe-matosus affects many parts of the body: primarily the skin and joints, but also the kidneys. Goodpasture's syndrome involves an autoantibody that specifically targets the kidneys and the lungs. IgA nephropathy is a form of glomerular disease that results when immunoglobulin A (IgA) forms deposits in the glomeruli, where it creates inflammation. Future research could look for how the disease occurs, and how to easily test for its presence so that early treatment could be started.

Moore E. Autoimmune diseases and their environmental triggers. Jefferson, NC: McFarland Publishing, 2002.

Schlondorff DO. Overview of factors contributing to the pathophysiology of progressive renal disease. Kidney Int 2008; 74: 860-6.

Segerer S, Kretzler M, Strutz F et al. Mechanisms of tissue injury and repair in renal diseases. In: Schrier R (ed). Diseases of the kidney and urinary tract. Lippincott. Philadelphia 2007, Chapter 57.

Levey AS, Eckardt KU, Tsukamoto Y, et al. Definition and classification of chronic kidney disease: a position statement from kidney disease, Kidney Int 2006; 67: 2089-100.

Kettritz R. Autoimmunity in kidney diseases. Scand J Clin Invest Suppl 2008; 241: 99-103.

O'Callaghan CA. Renal manifestations of systemic autoimmune disease: diagnostic and therapy. Nephrol Ther 2006; 3: 140-51.

Mason J, Asherson R, Pusey C. The kidney in systemic autoimmune diseases. Elsevier, 2007; p. 432.

Mason J, Pusey C. The kidney in systemic autoimmune diseases. In: Handbook of systemic autoimmune diseases. Series editor: R. A. Asherson. Elsevier, Oxford 2008; 7: p. 407.

Appel GB, Cook HT, Hageman G, et al. Membrano-proliferative glomerulonephritis type II (dense deposit disease): an update. J Am Soc Nephrol 2005; 16: 1392-403.

Sinico RA, Radice A, Corace C, Sabadini E, Bollini B. Anti-glomerular basement membrane antibodies in the diagnosis of Goodpasture syndrome: A comparison of different assays. Nephrol Dial Transplant 2006; 21: 397-401.

Lou YH. Anti-GBM glomerulonephritis: A T cell-mediated autoimmune disease? Arch immunol Ther Exp (Warsz) 2004; 52: 96-103.

Balow JE. Clinical presentation and monitoring of lupus nephritis. Lupus 2005; 14: 25-30.

Fakhouri F, Noel LH, Zuber J, et al. The expanding spectrum of renal diseases associated with anti-phospholipid syndrome. American Journal of Kidney Disease 2003; 41: 1205-11.

Vezmar S, Bode U, Jaehde U. Methotrexate-associated biochemical alterations in a patient with chronic neurotoxicity. Journal of Medical Biochemistry 2009; 28: 11-15.

Journal of Medical Biochemistry

The Journal of Society of Medical Biochemists of Serbia

Journal Information


IMPACT FACTOR 2017: 1.378
5-year IMPACT FACTOR: 0.704



CiteScore 2017: 1.05

SCImago Journal Rank (SJR) 2017: 0.307
Source Normalized Impact per Paper (SNIP) 2017: 0.532

Metrics

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 231 231 24
PDF Downloads 57 57 4