The Influence of Chronic Helicobacter Pylori Infection on some Serum Lipid Profile Parameters, Apolipoproteins A-I and B and Lp(a) Lipoprotein

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The Influence of Chronic Helicobacter Pylori Infection on some Serum Lipid Profile Parameters, Apolipoproteins A-I and B and Lp(a) Lipoprotein

Data on proatherogenic lipid profile alterations due to chronic Helicobacter pylori (HP) infection are contradictory. Aim of this study was to examine the differences in some lipid parameters between 55 subjects of both gender with a chronic HP infection (IgG>50 U/mL and IgA <20 U/mL) and 55 gender matched HP seronegative subjects (IgG and IgA <20 U/mL). Total cholesterol (TC) (p<0.001), triglycerides (TG) (p<0.05), LDL-cholesterol (LDL-C) (p<0.02), non-HDL-cholesterol (non-HDL-C), apolipoprotein (apo) B (p<0.001), Lp(a) and HDL-cholesterol (HDL-C) serum levels were higher in HP seropositive than in seronegative subjects, while there were almost no differences in apo A-I. In HP seropositive subjects, the frequency of pathological TC (p<0.001), TG (p<0.05), LDL-C (p<0.01), non-HDL-C (p<0.01), apo B (p<0.02) and Lp(a) serum levels was higher compared to seronegative. Serum HP IgG titers correlated negatively with TC, LDL-C (p<0.05), non-HDL-C, apo B and Lp(a) levels, and positively with TG, HDL-C and apo A-I levels. Results are similar for both genders. Our results confirm the hypothesis that a chronic HP infection could modify the lipid profile in a proatherogenic way.

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  • De Luis DA Garcia Avello A Lasuncion MA Aller R Martin De Argila C Boixeda De Miquel D De La Calle H. Improvement in lipid and haemostasis patterns after Helicobacter pylori infection eradication in type 1 diabetic patients. Clin Nutr 1999; 18 (4): 227-31.

  • Oshima T Ozono R Yano Y Oishi Y Teragawa H Higashi Y Yoshizumi M Masayuki Kambe M. Association of Helicobacter pylori Infection With Systemic Inflammation and Endothelial Dysfunction in Healthy Male Subjects. J Am Coll Cardiol 2005; 45: 1219-22.

  • Sawayama Y Ariyama I Hamada M Otaguro S Machi T Taira Y Hayashi J. Association between chronic Helicobacter pylori infection and acute ischemic stroke: Fukuoka Harasanshin Atherosclerosis Trial (FHAT). Atherosclerosis 2005; 178: 303-9.

  • Majka J Rog T Konturek PC Konturek SJ Bielanski W Kowalsky M Szczudlik A. Influence of chronic Helicobacter pylori infection on ischemic cerebral stroke risk factors. Med Sci Monit 2002; 8 (10): CR675-84.

  • Lu YH Yen HW Lin TH Huang CH Lee KT Wang WM Wu DC Voon WC Lai WT Sheu SH. Changes of coronary risk factors after eradication of Helicobacter pylori infection. Kaohsiung J Med Sci 2002; 18 (6): 266-72.

  • Niemela S Karttunen T Korhonen T Läärä E Karttunen R Ikäheimo M Kesäniemi YA. Could Helicobacter pylori infection increase the risk of coronary heart disease by modifying serum lipid concentrations? Heart 1996; 75: 573-5.

  • Georges JL Rupprecht HJ Blankenberg S Poirier O Bickel C Hafner G Nicaud V Meyer J Cambien F Tiret L. Impact of pathogen burden in patients with coronary artery disease in relation to systemic inflammation and variation in genes encoding cytokines. Am J Cardiol 2003; 92: 515-21.

  • Franceschi F Leo D Fini L Santoliquido A Flore R Tondi P Roccarina D Nista EC Cazzato AI Lupascu A Pola P Silveri NG Gasbarrini G Gasbarrini A. Helicobacter pylori infection and ischaemic heart disease: An overview of the general literature. Dig Liver Dis 2005; 37: 301-8.

  • Grabczewska Z Nartowicz E Kubica J Rošć D. Endothelial function parameters in patients with unstable angina and infection with Helicobacter pylori and Chlamydia pneumoniae. Eur J Intern Med 2006; 17: 339-42.

  • Hamed SA Amine NF Galal GM Helal SR Tag El Din LM Shawky OA Ahmed EA Abdel Rahman MS. Vascular Risks and Complications in Diabetes Mellitus: The Role of Helicobacter Pylori Infection. J Stroke Cerebrovasc Dis 2008; 17 (2): 86-94.

  • Chimienti G Russo F Lamanuzzi BL Nardulli M Messa C Di Leo A Correale M Giannuzzi V Pepe G. Helicobacter pylori is associated with modified lipid profile: impact on Lipoprotein(a). Clin Biochem 2003; 36: 359-65.

  • Mostaza JM Camino N Gerique JG Pena R Baquero M Lahoz C. C-reactive protein levels and prevalence of chronic infections in subjects with hypoalphalipoproteinemia. Metabolism 2005; 54: 33-7.

  • Lamb DJ El Sankary W Ferns GAA. Molecular mimicry in atherosclerosis: a role for heat shock proteins in immunisation. Atherosclerosis 2002; 167: 177-85.

  • Laurila A Bloigu A Nayha S Hassi J Leinonen M Saikku P. Association of Helicobacter pylori infection with elevated serum lipids. Atherosclerosis 1999; 142: 207-10.

  • Kayo S Ohsawa M Ehara S Naruko T Ikura Y Hai E Yoshimi N Shirai N Tsukamoto Y Itabe H Higuchi K Arakawa T Ueda M. Oxidized low-density lipoprotein levels circulating in plasma and deposited in the tissues: Comparison between Helicobacter pylori-associated gastritis and acute myocardial infarction. Am Heart J 2004; 148: 818-25.

  • Sung KC Rhee EJ Ryu SH Beck SH. Prevalence of Helicobacter pylori infection and its association with cardiovascular risk factors in Korean adults. Int J Cardiol 2005; 102: 411-7.

  • Aslan M Nazligul Y Horoz M Bolukbas C Bolukbas FF Gurc M Celik H Erel O. Serum paraoxonase-1 activity in Helicobacter pylori infected subjects. Atherosclerosis 2008; 196: 270-4.

  • Kucukazman M Yavuz B Sacikara M Asilturk Z Ata N Ertugrul D Yalcin A Kizilca G Yenigun E Ulger Z Nazligul Y. Evaluation of lipid levels in patients infected with Helicobacter pylori [abstract]. Atherosclerosis Supp 2008; 9 (1): 83.

  • Hoffmeister A Rothenbacher D Bode G Persson K Marz W Nauck MA Brenner H Hombach V Koenig W. Current infection with Helicobacter pylori but not seropositivity to Chlamydia pneumoniae or cytomegalovirus is associated with an atherogenic modified lipid profile. Arterioscler Thromb Vasc Biol 2001; 21: 427-32.

  • Kanbay M Gur G Yucel M Yilmaz U Boyacioglu S. Does eradication of Helicobacter pylori infection help normalize serum lipid and CRP levels? Dig Dis Sci 2005; 50: 1228-31.

  • Paximadas S Pagoni ST Kosmidis M Tsarouchas X Christou M Chatziantonakis N Papachilleos P. The lipid profile in adults with negative or positive antibody Helicobacter pylori [abstract]. Atherosclerosis Supp 2005; 6 (1): 74.

  • Friedewald TW Levy IR Fredrickson SD. Estimation of the concentration of LDL cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.

  • The Expert Panel. The Third Report of the National Education Program (NCEP) Expert Panel on Detection Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III); Final report. Circulation 2002; 106: 3143-421.

  • Longo-Mbenza B Nkondi Nsenga J Vangu Ngoma D. Prevention of the metabolic syndrome insulin resistance and the atherosclerotic diseases in Africans infected by Helicobacter pylori infection and treated by antibiotics. Int J Cardiol 2007; 121: 229-38.

  • Amir Kol A Libby P. The Mechanisms by Which Infectious Agents May Contribute to Atherosclerosis and Its Clinical Manifestations. Trends Cardiovasc Med 1998; 8: 191-9.

  • Libby P Ridker PM Maseri A. Inflammation and Atherosclerosis. Circulation 2002; 105: 1135-43.

  • Hansson GK Libby P Uwe Schonbeck U Yan Z-Q. Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis. Circ Res 2002; 91: 281-91.

  • Naito Y Yoshikawa T. Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress. Free Radic Biol Med 2002; 33 (3): 323-36.

  • Scharnagl H Kist M Grawitz AB Koenig W Wieland H März W. Effect of Helicobacter Pylori Eradication on High-Density Lipoprotein Cholesterol. Am J Cardiol 2004; 93: 219-20.

  • Hyka N Dayer JM Modoux C Kohno T Edwards III CK Roux-Lombard P Burger D. Apolipoprotein A-I inhibits the production of interleukin-1beta and tumor necrosis factor-alpha by blocking contact-mediated activation of monocytes by T lymphocytes. Blood 2001; 97: 2381-9.

  • Tietge UJ Maugeais C Lund-Katz S Grass D DeBeer FC Rader DJ. Human secretory phospholipaseA2 mediates decreased plasma levels of HDL cholesterol and apoA-I in response to inflammation in human apoA-I transgenic mice. Arterioscler Thromb Vasc Biol 2002; 22: 1213-8.

  • Russo F Jirillo E Clemente C. Circulating cytokines and gastrin levels in asymptomatic subjects infected by Helicobacter pylori (H. pylori). Immunopharmacol Immunotoxicol 2001; 23: 13-24.

  • Ramharack R Barkalow D Spahr M. Dominant negative effect of TGF-beta1 and TNF-alpha on basal and IL-6 induced Lipoprotein(a) and apolipoprotein(a) mRNA expression in primary monkey hepatocyte cultures. Arterioscler Thromb Vasc Biol 1998; 18: 984-90.

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