Metabolic Disturbances In The Patients With Acute Ischemic Stroke

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The purpose of this study was to analyze the disturbances of glucose, lipid and protein metabolism in acute ischemic stroke patients. A total of 258 patients (mean age 70.9±7.22 years, range 49-92 years) were studied. The following parameters were examined: blood glucose, triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, creatinine, and urea. Data were statistically processed by variation and correlation analysis. Our results demonstrated abnormal values of these laboratory parameters in most patients. The mean concentrations of triglycerides, total cholesterol and LDL-cholesterol were higher in females, while these of blood glucose were higher in males, especially in the age group between 76 and 80 years. Pearson’s correlation coefficient was highest between the variables ‘total cholesterol’ and ‘LDL-cholesterol’ (r=0.797) but moderate - between some of the rest variables such as ‘creatinine’ and ‘urea’ (r=0.575); ‘total cholesterol’ and ‘triglycerides’ (r=0.565); ‘total cholesterol’ and ‘urea’ (r=0.428); ‘triglycerides’ and ‘urea’ (r=0.370) and ‘LDL-cholesterol’ and ‘urea’ (r=0.301). In conclusion, the metabolic disorders are relatively common among acute ischemic stroke patients and play a specific role as risk factors for this disease. These parameters should regularly be controlled within the outpatient practice in order to warrant an effective prevention of acute ischemic stroke.

1. Lisak M, Demarin V, Trkanjec Z, Basić-Kes V. Hypertriglyceridemia as a possible independent risk factor for stroke. Acta Clin Croat. 2013;52(4):458-63.

2. Fonville S, den Hertog HM, Zandbergen AA, Koudstaal PJ, Lingsma HF. Occurrence and predictors of persistent impaired glucose tolerance after acute ischemic stroke or transient ischemic attack. J Stroke Cerebrovasc Dis. 2014;23(6):1669-75.

3. Sultan S, Schupf N, Dowling M, DeVeber G, Kirton A, Elkind MS; IPSS Investigators. Predictors of cholesterol and lipoprotein(a) testing in children with arterial ischemic stroke. J Stroke Cerebrovasc Dis. 2014;23(9):2405-13.

4. Tsukinoki R, Okamura T, Watanabe M, Kokubo Y, Higashiyama A, Nishimura K, et al. Blood pressure, low-density lipoprotein cholesterol, and incidences of coronary artery disease and ischemic stroke in Japanese: the Suita Study. Am J Hypertens. 2014;27(11):1362-9.

5. Bharosay A, Bharosay VV, Bandyopadhyay D, Sodani A, Varma M, Baruah H. Effect of lipid profile upon prognosis in ischemic and haemorrhagic cerebrovascular stroke. Indian J Clin Biochem. 2014;29(3):372-6.

6. Arauz A, Romano JG, Ruiz-Franco A, Shang T, Dong C, Rundek T, et al. Differences in lipid profiles in two Hispanic ischemic stroke populations. Int J Stroke. 2014;9(4):394-9.

7. Ferket BS, van Kempen BJ, Wieberdink RG, Steyerberg EW, Koudstaal PJ, Hofman A, et al. Separate prediction of intracerebral hemorrhage and ischemic stroke. Neurology. 2014; 82(20):1804-12.

8. Mei L, Fang X, Mu L, Liu H, Zhang H, Qin X, et al. Association of serum high-density lipoprotein cholesterol level and risk of recurrent ischemic stroke. Zhonghua Xin Xue Guan Bing Za Zhi. 2014;42(4):295-300. Chinese.

9. Jaffre A, Ruidavets JB, Calviere L, Viguier A, Ferrieres J, Larrue V. Risk factor profile by etiological subtype of ischemic stroke in the young. Clin Neurol Neurosurg. 2014;120:78-83.

10. Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, et al. Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study. Atherosclerosis. 2014;233(2):343-8.

11. Shen H, Zhou J, Shen G, Yang H, Lu Z, Wang H. Correlation between serum levels of small, dense low-density lipoprotein cholesterol and carotid stenosis in cerebral infarction patients >65 years of age. Ann Vasc Surg. 2014;28(2):375-80.

12. Xu T, Zhang JT, Yang M, Zhang H, Liu WQ, Kong Y, et al. Dyslipidemia and outcome in patients with acute ischemic stroke. Biomed Environ Sci. 2014;27(2):106-10.

13. Gezmu T, Schneider D, Demissie K, Lin Y, Giordano C, Gizzi MS. Lipid profiles and ischemic stroke risk: variations by sex within racial/ethnic groups. Int J Womens Health. 2014;6:585-95.

14. Markaki I, Nilsson U, Kostulas K, Sjöstrand C. High cholesterol levels are associated with improved long-term survival after acute ischemic stroke. J Stroke Cerebrovasc Dis. 2014;23(1):e47-53.

15. Pikija S, Trkulja V, Juvan L, Ivanec M, Dukši D. Higher on-admission serum triglycerides predict less severe disability and lower all-cause mortality after acute ischemic stroke. J Stroke Cerebrovasc Dis. 2013;22(7):e15-24.

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