Degradation dynamics and dissipation kinetics of an imidazole fungicide (Prochloraz) in aqueous medium of varying pH
Laboratory degradation studies were performed in water at pH 4.0, 7.0 and 9.2 using Prochloraz (450 EC) formulation at the concentration of 1.0 (T1) and 2.0 (T2) μg/mL. Water samples collected on 0 (2 h), 3, 7, 15, 30, 45, 60 and 90 days after treatments were processed for residue analysis of Prochloraz by HPLC-UV detector. In 60 days, dissipation was 89.1-90.5% at pH 4.0, 84.1-88.2% at pH 7.0, and 92.4-93.8% at pH 9.2 in both treatments. The results indicate that at pH 7.0 the degradation of Prochloraz was much slower as compared to other two. Between pH 4.0 and 9.2 the degradation of compound is little faster at pH 9.2. The half-life periods observed were 18.35 and 19.17 days at pH 4.0, 22.6 and 25.1 days at pH 7.0 and 15.8 and 16.6 days at pH 9.2 at T1 and T2 doses respectively.
Ankley GT, Jensen KM, Durhan EJ, Makynen EA, Butterworth BC, Kahl MD, Villeneuve DL, Linnum A, Gray LE, Cardon M, Wilson VS. (2005). Effects of two fungicides with multiple modes of action on reproductive endocrine function in the fathead minnow (Pimephales promelas). Toxicological Sciences86(2): 300-308.
Ankley GT, Jenson KM, Kahl MD, Makynen EA, Blake LS, Greene KJ, Johnson RD, Villeneuve DL. (2007). Ketoconazole in the fathead minnow (Pimephales promelas): Reproductive Toxicity and Biological Compensation. Environmental Toxicology and Chemistry26(6): 1214-1223.
Balmas V, Maccaroni M, Santori A, Corazza L. (1999). Fusariosi della spiga di cereali autunno-vernini: indagine epidemiologica e valutazione della resistenza varietale di frumento duro nell'Italia centrale. Informatore Fitopatologico49(12): 37-42.
Corazza L, Balmas V, Santori A, Vitale SL, Maccaroni M. (2001). Head blight and foot rot of wheat in Italy. In: Proceedings of the Conference ‘Sustainable Systems of Cereal Crop Protection against Fungal Diseases as the Way of Reduction of Toxin Occurence in Food Webs’ Kromeriz, Czech Republic: 25-36.
Cravedi JP, Boudry G, Baradat M, Rao D, Debrauwer L. (2001). Metabolic Fate of 2,4-Dichloroaniline, Prochloraz and Nonylphenol Diethoxylate in Rainbow Trout: A Comparative In vivo/In vitro Approach. Aquat Toxicol53(3/4): 159-172.
Davide P, Annamaria P, Ilaria A, Santina R. (2004). Control of Fusarium head blight and accumulation of deoxynivalenol in durum wheat grain, semolina and bran. Phytopathol Mediterr43: 351-359.
Debrauwer L, Rathahao E, Boudry G, Baradat M, Cravedi JP. (2001). Identification of the major metabolites of prochloraz in rainbow trout by liquid chromatography and tandem mass spectrometry. J Agric Food Chem49(8): 3821-6.
Gac LF, Thomas JL, Mourot B, Loir M. (2001). In vivo and In vitro Effects of Prochloraz and Nonylphenol Ethoxylates on Trout Spermatogenesis. Aquat Toxicol53(3/4): 187-200.
Kato Y, Flodström S, Wärngard L. (1998). Initiation and promotion of altered hepatic foci in female rats and inhibition of cell-cell communication by the imidazole fungicide prochloraz. Chemosphere37: 393-403.
Laignelet L, Rivière JL, Lhuguenot JC. (1992). Metabolism of an imidazole fungicide (prochloraz) in the rat after oral administration. Food Chem Toxicol30: 575-583.
Li DW, Hsiang T, Ross JB. (2000). The Effects of Various Fungicides on the Control of Overwintering Diseases. Prairie Turfgrass Research Centre Annual Report, 17-19.
Needham D, Challis IR. (1991). The metabolism and excretion of prochloraz, an imidazole-based fungicide, in the rat. Xenobiotica21: 1473-1482.
Pancaldi D, Grazzi G, Alberti I. (1996). La fusariosi della spiga di frumento in Emilia Romagna nel 1995. Informatore Fitopatologico46(4): 16-20.
Rivière JL. (1983). Prochloraz, a potent inducer of the microsomal cytochrome P450 system. Pestic Biochem Physiol19: 44-52.
Sturm A, Cravedi JP, Perdu E, Baradat M, Segner H. (2001). Effects of prochloraz and nonylphenol diethoxylate on hepatic biotransformation enzymes in trout: a comparative in vitro/in vivo-assessment using cultured hepatocytes. Aquat Toxicol53(3/4): 215-228
Vinggaard AM, Hass U, Dalgaard M, Andersen HR, Bonefeld-Jørgensen E, Christiansen S, Laier P, Poulsen ME. (2006). Prochloraz: an imidazole fungicide with multiple mechanisms of action. Int J Androl29(1): 186-92.