Advances in the Study on the Relationship between Regulatory T cells and Human Papilloma Viral Infection

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Abstract

Regulatory T cells (Treg cells) are a group of negative regulatory cells that include non-specific immune regulation CD4+ T cells. Treg cells inhibit the function of other immune cells. CD4+ CD25+ FOXP3+ is a Treg cell that is co-expressed by CD25 and FOXP3. The expression of Treg cells is up-regulated in the focal microenvironment and peripheral blood of patients infected with human papilloma virus (HPV). Further studies on Treg cells indicate that their potential clinical applications in the treatment of HPV infection.

1 Gemhon RK, Kondo K. Infectious immunological tolerance[J]. Immunology, 1971, 21(6): 903-914.

2 Gershon RK, Kondo K. Cell interactions in the induction of tolerance: the role of thymic lymphocytes. Immunology, 1970, 18(5): 723-737.

3 Fujimoto S, Greene M, Sehon AH. Immunosuppressor T cells in tumor bearing host. Immunol Commun, 1975, 4 (3): 201-217.

4 Berendt MJ, North RJ. T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor. J Exp Med, 1980, 151(1): 69-80.

5 Bursuker I, North RJ. Generation and decay of the immune response to a progressive fibrosarcoma. II. Failure to demonstrate postexcision immunity after the onset of T cell-mediated suppression of immunity. J Exp Med, 1984, 159(5): 1312-1321.

6 North RJ, Bursuker I. Generation and decay of the immune response to a progressive fibrosarcoma. I. Ly-1 + 2-suppressor T cells down-regulate the generation of Ly-1-2 + effecter T cells. J Exp Med, 1984, 159(5): 1295-1311.

7 Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains(CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol, 1995, 155(3): 1151-1164.

8 Li F, Li Y, Wu S, et al. Distribution of Human Papilloma Virus High Risk Subtypes in Patients with Condyloma Acuminatum. Chinese Journal of Nosocomiology, 2012, 22 (1): 210-212.

9 Sun G. Relationship between Human Papillomavirus Infection and Regulatory T Lymphocyte and Helper T Cell 17 in Patients with Condyloma Acuminatum. Chinese Journal of Clinicians (Electronic Edition), 2013, 7 (9): 4069-4071.

10 Vici P, Mariani L, Pizzuti L, et al. Immunologic treatments for precancerous lesions and uterine cervical cancer. J Exp Clin Cancer Res, 2014, 33(1): 29-44.

11 Zeng C, Yao Y, Jie W, et al. Up-regulation of Foxp3 participates in progression of cervical cancer. Cancer Immunol Immunother, 2013, 62(3): 481-487.

12 Cao X, Xiong S, Yao Z. Medical immunology. Sixth Edition. Beijing: People's Medical Publishing House, 2013: 83-85.

13 Cao X, Xiong S, Yao Z. Medical immunology. Sixth Edition. Beijing: People's Medical Publishing House, 2013: 88-89.

14 Cao X, Xiong S, Yao Z. Medical immunology. Sixth Edition. Beijing: People's Medical Publishing House, 2013: 91.

15 Sakaguchi S, Yamaguchi T, Nomura T, et al. Regulatory T cells and immune tolerance. Cell, 2008, 5(9): 775-787.

16 Tosolini M, Kirilovsky A, Mlecnik B, et al. Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer. Cancer Res, 2011, 71(12): 63-71.

17 Fontenot JD, Gavin MA, Rudensky AY, et al. Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells. Nat Immunol, 2003, 4(4): 330-336.

18 Liu F, Weng D, Chen Y, et al. Depletion of CD4+ CD25+ Foxp3+ regulatory T cells with anti-CD25 antibody may exacerbate the 1, 3-β-glucan-induced lung inflammatory response in mice. Arch Toxicol, 2011, 85(11): 1383-1394.

19 Kim HP, Leonard WJ. CREB/ATF-dependent T cell receptor-induced Foxp3 gene expression: a role for DNA methylation. J Exp Med, 2007, 204(7): 1543-1551.

20 Zheng Y, Josefowicz S, Chaudhry A, et al. Role of conserved noncoding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature, 2010, 463(7282): 808-812.

21 Lal G, Bromberg JS. Epigenetic mechanisms of regulation of Foxp3 expression. Blood, 2009, 114(18): 3727-3735.

22 Josefowicz SZ, Rudensky A. Control of regulatory T cell lineage commitment and maintenance. Immunity, 2009, 30(5): 616-625.

23 Ralainirina N, Poli A, Michel T, et al. Control of NK cell functions by CD4+ CD25+ regulatory T cells. J Leukoc Biol, 2007, 81(1): 144-153.

24 Wei H, Yang M, Zhao T, et al. Functional expression and characterization of grass carp IL-10: an essential mediator of TGF-β1immune regulation in peripheral blood lymphocytes. Mol Immunol, 2013, 53(4): 313-320.

25 Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol, 2008, 8(7): 523-532.

26 Zeng R, Fang G, Wei Lin. The Role of CD4+ T cells in Tumor Immunotherapy. Chinese Journal of Cell Biology, 2008, 30 (1): 30-34.

27 Dunn GP, Old LJ, Schreiber RD, et al. The three Es of cancer immunoediting. Annu Rev Immunol, 2004, 22(12): 329-360.

28 Zhan X, Xiao L, Zhang Z, et al. Expression and Significance of FOXP3 in Renal Tissues of Patients with Hepatitis B Virus Associated Glomerulonephritis. World Chinese Journal of Digestology, 2013, 21(10): 851 – 857

29 Cao X, Xiong S, Yao Z. Medical immunology. Sixth Edition. Beijing: People's Medical Publishing House, 2013: 90-91.

30 Wang W, Zheng L, Sun Z. HPV Typing Analysis of 67 Condyloma Acuminatum Patients. Chinese Journal of Human Sexuality, 2013, 02 (65): 53-54.

31 Liu Q, Hu F, Zhao J, et al. Expression of YKL-40 and VEGF in Condyloma Acuminatum Tissues. Academic Journal of Second Military Medical University, 2013, 34 (6): 639-644.

32 Ciobotaru B, Leiman G, St John T, et al. Prevalence and risk factors for anal cytologic abnormalities and human papillomavirus infection in a rural population of HIV-infected males. Diseases of the Colon and Rectum, 2007, 50(7): 1011-1016.

33 Hillemanns P, Ellerbrock TV, McPhillips S. Prevalence of anal human papillomavirus infection and anal cytologic abnormalities in HIV-seropositive women. AIDS, 1996, 10(14): 1641-1647.

34 Xu Y, Ye J, Zhu K, et al. Detection of CD4+ CD25+ Foxp3+ Regulatory T Cells in the Peripheral Blood of Patients with Condyloma Acuminatum and Its Significance. Chinese Journal of Infectious Diseases, 2009, 27 (8): 484-486.

35 Wang J, Wang Q, Xu H, et al. Detection of CD4+ CD25+ Foxp3+ Regulatory T Cells in the Peripheral Blood of Patients with Condyloma Acuminatum and Its Association with HPV Subtypes. The Chinese Journal of Dermatovenereology, 2014, 06 (560): 562-566.

36 Xie X, Gou W, Lin Z, et al. Gynecology. Eighth Edition. Beijing: People's Medical Publishing House, 2013: 304-309.

37 Zur Hausen H. Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis. J Natl Cancer Inst, 2000, 92(9): 690-698.

38 Yang X, Lu L. Expression of HPV-16 E6 Protein and p53 inactivation increases the uterine cervical cancer invasion. Drug Res(Stuttg), 2015, 65(2): 70-73.

39 Abraham J, Stenger M. Cobas HPV test for first-line screening for cervical cancer. J Community Support Oncol, 2014, 12 (5):156-157.

40 Austin RM, Zhao CA. Is 58% sensitivity for detection of cervical intraepithelial neoplasia 3 and invasive cervical cancer optimal for cervical screening? Cyto Journal, 2014, 11(14): 1-14.

41 Wang Z, Li L, Li J, et al. Detection of HPV DNA and Its Relationship with Peripheral T Cell Subsets in Patients with Condyloma Acuminatum. Chinese Journal of Experimental and Clinical Virology, 2001, 15 (3): 254-255.

42 Tan X, Xu H, Guo L, et al. Changes of T lymphocytes immune functions of cervical cancer patients with postoperative infections and analysis of clinical significance. Chinese Journal of Nosocomiology, 2015, 25 (6): 1270-1272.

43 Fu T, Yang P, Jiao Z. Distribution and Significance of Th17/Th1 Cells in the Peripheral Blood and Tumor Tissue from Patients with Cervical Cancer. Journal of Jiangsu University (Medicine Edition), 2011, 21(2): 155-158.

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