The author reflects on the issue of the value of human life in the contexts of current “posthuman” era. There is a host of evidence that the value of human for human beings themselves has been radically reduced or ignored, or replaced by other non-human values, and even neglected. The axiological crisis of humanity, as envisioned by Nietzsche, has become the existential and moral crisis of humanity today. No matter how contemporary technological culture challenges the traditional values, the ancient questions of “how to live?”, “what makes us happy?”, and “what makes life significant?” are still here with us and provide even greater challenges to every individual. The author points to pluralist ways of how to deal with these questions including the “stoic pragmatism” among them.