Arsenic Speciation in Tobacco and Cigarette Smoke

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Abstract

Arsenic is one of the metals found in cured tobacco and mainstream cigarette smoke. Levels of arsenic in modern filtered cigarette smoke range from sub-ppm to a few tens of ppms. To enable accurate smoke toxicity assessment on arsenic in cigarette smoke, it is desirable to establish its chemical forms in addition to total quantities because different arsenic compounds possess different toxicological potentials.

Progress has been made on measuring the arsenic speciation in tobacco and mainstream cigarette smoke by using a combination of synchrotron-based X-ray absorption spectroscopy and high-performance liquid chromatography- inductively coupled plasma mass spectrometry (HPLC-ICP-MS). In this paper, we describe the experimental procedures developed together with the main findings. A transient redox transformation between As(V) and As(III) was confirmed in freshly generated mainstream smoke. Potential areas for future research are highlighted in order to further our understanding of the speciation mechanism for arsenic in tobacco products.

1. Hoffmann, D. and S.S. Hecht: Advances in tobacco carcinogenesis; in: Chemical carcinogenesis and mutagenesis. I; edited by C.S. Cooper and P.L. Grover, Springer-Verlag, London, UK, 1990, chapter 3, pp. 63–102.

2. Chen, P.X. and S.C. Moldoveanu: Mainstream Smoke Chemical Analyses for 2R4F Kentucky Reference Cigarette; Beitr. Tabakforsch. Int. 20 (2003) 448–458.

3. International Agency for Research on Cancer (IARC): Evaluation of the carcinogenic risk of chemicals to humans: Tobacco smoking; IARC, Lyon, France, IARC Monograph 38 (1985) p. 394.

4. Abernathy, C.O., D.J. Thomas, and R.L. Calderon: Health effects and risk assessment of arsenic; J. Nutr. 133 (2003) 1536S–1538S.

5. Hughes, K., M.E. Meek, and R. Burnett: Inorganic Arsenic: Evaluation of Risks to Health from Environmental Exposure in Canada; J. Environ. Sci. Health, Part C 12 (1994) 145–149.

6. Devesa, V., D. Velez, and R. Montoro: Effect of thermal treatment on arsenic species contents in food; Food Chem. Toxicol. 46 (2008) 1–8.

7. Liu, C., J. Hu, and K.G. McAdam: A feasibility study on oxidation state of arsenic in cut tobacco, mainstream cigarette smoke and cigarette ash by X-ray absorption spectroscopy; Spectrochim. Acta. B 64 (2009) 1294–1301.

8. Taebunpakul, S., C. Liu, C. Wright, K.G. McAdam, J. Heroult, J. Braybrook, and H. Goenaga-Infante: Determination of total arsenic and arsenic speciation in tobacco products: from tobacco leaf and cigarette smoke; J. Anal. At. Spectrom. 26 (2011) 1633–1640.

9. McRae, D.D.: The physical and chemical nature of tobacco; Rec. Adv. Tob. Sci. 16 (1990) 233–323.

10. Borgerding, M. and H. Klus: Analysis of complex mixtures - cigarette smoke; Exp. Toxicol. Pathol. 57 (2005) 43–73.

11. Schmeltz, I., J. Tosk, G. Jacobs, and D. Hoffmann: Redox potential and quinine content of cigarette smoke; Anal. Chem. 49 (1977) 1924-1929.

12. Pourbaix, M: Atlas of electrochemical equilibria in aqueous solutions; National Association of Corrosion Engineers, Houston, TX, 2nd English ed., 1974.

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CiteScore 2017: 0.63

SCImago Journal Rank (SJR) 2017: 0.309
Source Normalized Impact per Paper (SNIP) 2017: 0.403

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