Fabrication of Size-Tunable Silica Particles During Seed-Growth Process

Open access

The size control is one of the most important factors during seed-growth process. Although precise determination of ingredients concentrations is easily controllable during the growth process, there is still a possibility to synthesize oversized particles. Nanosized fluorescent silica particles were synthetized using Stöber process and verified using three complementary methods of particle size determination, namely Dynamic Light Scattering (DLS), Particle Tracking (PT) as well as by Transmission Electron Microscopy (TEM) and Confocal Microscopy. The final diameter was verified by DLS and estimated to 494 nm. Parameters necessary to control the size were derived.

Bell N. C., Minelli C., Tompkins J., Stevens M. M. & Shard A. G. (2012) Emerging Techniques for Submicrometer Particle Sizing Applied to Stöber Silica, Langumir, 28, 10860-10872.

Berne B.J., Pecora R., (1976) Dynamic Light Scattering: with Applications to Chemistry, Biology, and physics, Wiley, New York.

Bogush, G. H.; Tracy, M. A.; Zukoski, Iv, C. F. (1988) Preparation of Monodisperse Silica Particles: Control of Size and Mass Fraction. J. Non-Cryst. Solids, 104 (1), 95-106.

Bogush, G. H., Zukoski, Iv, C. F. (1991) Uniform Silica Particle Precipitation: An Aggregative Growth Model., J. Colloid Interface Sci., 142, 19 - 34.

Bogush, G. H., Zukoski, Iv, C. F. (1991) Studies of the Kinetics of the Precipitation of Uniform Silica Particles through the Hydrolysis and Condensation of Silicon Alkoxides., J. Colloid Interface Sci., 142, 1 - 18.

Canton G., Ricco R., Marinello F., Carmignato S., Enrichi F.,(2011) Modified Stöber synthesis of highly luminescent dye-doped silica nanoparticles., J. Nanopart. Res., 13, 43494356.

Irvine D. (2011) One particle, one kill, Nature Materials, 10, 342-343.

Jesionowski T., Krysztafkiewicz A. (2002) Preparation of the hydrophilic/hydrophobic silica particles., Colloids and Surfaces A: Physicochem. Eng. Aspects, 207, 49-58.

Krysztafkiewicz A., Binkowski S., Jesionowski T. (2002) Adsorption of dyes on a silica surface. Applied Surface Science, 199, 31-39.

Liu Y., Miyoshi H., Nakamura M. (2007), Novel drug delivery system of hollow mesoporous silica nanocapsules with thin shells: Preparation and fluorescein isothiocyanate (FITC) release kinetics, Colloids and Surfaces B: Biointerfaces 58, 180-187.

Liz-Marzan L. M., Giersig M. & and Mulvaney P. (1996), Synthesis of Nanosized Gold-Silica Core-Shell Particles, Langmuir, 12, 4329-4335.

Malloy A. (2011) Count, size and visualize nanoparticles, Materials Today, 14 (4), 170-173.

NanoSight (2012a) NTA 2.3 Analytical Software, Operating Manual P554J, Technical data, NanoSight Ltd., Minton Park, Amesbury, Wiltshire SP4 7RT, UK.

NanoSight (2012b) General Characterization Brochure Technical data, NanoSight Ltd., Minton Park, Amesbury, Wiltshire SP4 7RT, UK.

Provencher S.W. (1982). CONTIN: A general purpose constrained regularization program for inverting noisy linear algebraic and integral equations. Comput. Phys. Commun. 27, 229-232.

Vijayakameswara Rao N, Mutyala Naidu Ganivada, Santu Sarkar, Himadri Dinda, Koushik Chatterjee, Tanmoy Dalui, Jayasri Das Sarma, and Raja Shunmugam, (2013), Magnetic Norbornene Polymer as Multi-responsive Nanocarrier for Site Specific Cancer Therapy, Bioconjugate Chemistry. Just Accepted Manuscript, DOI: 10.1021/bc400409n.

Rejeeth, Nag & Kannan (2013), Cisplatin-functionalized silica nanoparticles for cancer chemotherapy, Cancer Nano, 4, 127-136.

Stöber, W.; Fink, A.; Bohn, E. (1968) Controlled growth of monodisperse silica spheres in the micron size range. J. Colloid Interface Sci., 26 (1), 62-69.

van Blaaderen A. &. Kentgens A.P.M (1992) Particle morphology and chemical microstructure of colloidal silica spheres made from alkoxysilanes. Journal of Non-Crystalline Solids, 149, 161-178.

van Blaaderen A. & Vrij A. (1992) Synthesis and Characterization of Colloidal Dispersions of Fluorescent, Monodisperse Silica Spheres. Langmuir, 8, 2921-2931.

van Blaaderen A. & Vrij A. (1993) Synthesis and Characterization of Monodisperse Colloidal Organo-silica Spheres., J. Colloid Interface Sci., 256, 1-18.

Verhaegh N. A. M. & van Blaaderen A. (1994) Dispersions of Rhodamine-Labeled Silica Spheres: Synthesis, Characterization, and Fluorescence Confocal Scanning Laser Microscopy., Langmuir, 10, 1427-1438.

Żurawska J., Krysztafkiewicz A. & Jesionowski T. (2003) Physicochemical properties, surface morphology and particle size distribution of precipitated silicas., Surf. Interface Anal., 35, 914-921.