Tumefactive Multiple Sclerosis Mimicking Neoplasm

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Tumefactive Multiple Sclerosis Mimicking Neoplasm

Acute demyelination may present as a rapidly expanding space-occupying or tumefactive lesion (TDL). Tumefactive demyelinating lesions are misdiagnosed quite frequently and can result in unnecessary and potentially harmful surgical resection, radiation or toxic chemotherapeutic interventions therapy. Systematic literature review from available articles and abstracts in PubMed database was summarized in purpose to describe typical presentation and diagnostically challenging features of TDL. One clinical case report presenting tumor-like lesion of the brain, when the diagnosis of TDL was established, is added as an illustrative material.

Bower RS, Burrus TM, Giannini C, Erickson BJ, Meyer FB, Pirko I, Mauermann ML. Teaching NeuroImages: Demyelinating disease mimicking butterfly high-grade glioma // J Neurol, 2010;75: e4-e5

Brück W. The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage.// J Neurol, 2005;252(5)V/3-V/9

Caroli E, Salvati M, Ferrante L. Tumor-like multiple sclerosis: report of four cases and literature review // Tumori, 2006;92(6):559-62

Confavreux C, Vukusic S. Natural history of multiple sclerosis: a unifying concept //J Neurol Neurosurg Psychiatry, 2005;76:1693-1697

Curtis A, Given B, Scott S, Lee C. The MRI Appearance of Tumefactive Demyelinating Lesions // AJR, 2004; 182:195-199

Kim DS, Na DG, Kim KH, Kim J, Kim E, Yun BL, Chang KH. Distinguishing Tumefactive Demyelinating Lesions from Glioma or Central Nervous System Lymphoma: Added Value of Unenhanced CT Compared with Conventional Contrast-enhanced MR Imaging1 // Radiology, 2009; 251:467-475

Eleptheria EM, Evangelopoulos DS, Potagas C, Sfagos C. Homonymous hemianopsia as the leading symptom of a tumor like demyelinating lesion: a case report // Cases Journal, 2009; 2:9366

Aria F, Banglawala S, Ebrahim S, Paulseth JE, Jha NK. Tumefactive demyelinating lesions: a diagnostic challenge // Can J Surg, 2010;53(1):69-70

Lucchinetti CF, Gavrilova RH, Metz I, Parisi JE, Scheithauer BW, Weigand S, K. Thomsen K, Mandrekar J, Altintas A, Erickson BJ, Konig F, Giannini C, Lassmann H, Linbo L, Pittock SJ, Bruck W. Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis //Brain, 2008;131:1759-75

Malhotra HS, Jain KK, Agarwal A, Singh MK, Yadav SK, Husain M. Characterization of tumefactive demyelinating lesions using MR imaging and in-vivo proton MR spectroscopy //Mult Scler, 2009;15:193-203

Koch M, Uyttenboogaart M, Polman S, Keyser JD. Seizures in multiple sclerosi.//Epilepsia, 2008;49(6):948-953

Navarro S, Mondéjar-Marín B, Pedrosa-Guerrero A, Pérez-Molina I, Garrido-Robres JA, Alvarez-Tejerina A. Aphasia and parietal syndrome as the presenting symptoms of a demyelinating disease with pseudotumoral lesions // Rev Neurol., 2005;16-30;41(10):601-3

Pittock SJ, McClelland RL, Achenbach SJ, Konig F, Bitsch A, Bruøck W, Lassmann H, Parisi JE, Scheithauer BW, Rodriguez M, Weinshenker BG, Lucchinetti CH. Clinical course, pathological correlations, and outcome of biopsy proved inflammatory demyelinating disease // Brain, 2006; 129:606-616

Poser S, Luer W, Bruhn H, Frahm J, Bruck Y, Felgenhauer K. Acute demyelinating disease. Classification and non-invasive diagnosis // Acta Neurol Scand, 1992; 86: 579-85

Puri V, Chaudhry N, Gulati P, Tatke M, Singh D. Recurrent tumefactive demyelination in a child // J Clin Neurosci, 2005;12:495-500

Saindane AM, Cha S, Law M, Xue X, Knopp EA, and Zagzag D. Proton MR Spectroscopy of Tumefactive Demyelinating Lesions // AJNR Am J Neuroradiol, 2002; 23:1378-1386

Sinha MK, Garg RK, Bhatt M, Chandra A. Tumefactive demyelinating lesion: Experience with two unusual patients // J Postgrad Med, 2010; 56:146-9

Takeuchi T, Ogura M, Sato M, Kawai N, Tanihata H, Takasaka I, Minamiguchi H, Nakai M, Itakura T. Late-onset tumefactive multiple sclerosis // Radiat Med., 2008; 26(9):549-52

Tan HM, Chan L, Chuan L, Goh NSS, Tang KK. Case report. Monophasic, solitary tumefactive demyelinating lesion: neuroimaging features and neuropathological diagnosis // The British Journal of Radiology, 2004;(77), 153-156

Augusto TM, Machado A, Callegaro D, Marino R. Spinal cord tumor in a patient with multiple sclerosis // Arq Neuropsiquiatr, 2002; 60(2-B): 475-477

VanLandingham M, Hanigan W, Vedanarayanan V, Fratkin J. An uncommon illness with a rare presentation: neurosurgical management of ADEM with tumefactive demyelination in children // Childs Nerv Syst., 2010; 26(5):655-61

Satoshi Y, Kimura E, Hirano T, Uchino M. Tumefactive Multiple Sclerosis // Inter Med, 2009; 48:1113-1114

Acta Chirurgica Latviensis

The Journal of Riga Stradins University; Latvian Association of Surgeons; Latvian Association of Paediatric Surgeons

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