Organochloride Pesticides in Macedonian Girls With Premature Sexual Development

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Organochloride Pesticides in Macedonian Girls With Premature Sexual Development

Premature sexual development (PSD) in girls describes the appearance of secondary sexual signs before the age of 8 years. Early puberty is diagnosed if pubertal signs appear between the age of 8 and 9 years. We found a positive association between the levels of organochloride pesticides (p,p'-DDE) in precocious puberty in girls adopted from developing countries and significantly higher levels than in native Belgian girls with the same condition.

We have compared the serum levels of eight p,p'- DDE in 56 Macedonian girls with PSD and a control group of 24 normal, age-matched girls, using a gas chromatographic analyzer coupled to a tandem mass spectrometer detector. Of the 56 girls with PSD, 42 had premature thelarche, five had early puberty, and nine had precocious puberty of idiopathic (n = 8) or organic (n = 1) origin. We found traces of p,p'- DDE in nine girls (16%) and negative results in 41 (73%), while the remaining six (10%) had a mean level of 1.17 ± 0.7 μg/L. In the control group, traces were found in one girl (4%) and negative results in 18 (75%), while the remaining five (20%) had a mean level of 1.18 ± 0.6 μg/L. We found elevated levels of lindane in the girls with PSD (mean value 1.2 ± 0.8) and significantly higher levels in the control group (1.4 ± 0.8) (p <0.05). We concluded that Macedonian girls with PSD do not have higher levels of p,p'-DDE in their serum than the normal controls. However, the elevated levels of lindane in this population should be further investigated.

Ritzen EM. Early puberty: what is normal and when is treatment indicated? Horm Res 2003; 60 (Suppl 3): 31-34.

Wyshak G, Frisch RE. Evidence for a secular trend in age of menarche. N Engl J Med 1982; 306(17): 1033-1035.

Krstevska-Konstantinova M, Charlier C, Craen M, Du Caju M, Heinrichs C, de Beaufort C, Plomteux G, Bourguignon JP. Sexual precocity after immigration from developing countries to Belgium: evidence of previous exposure to organochloride pesticides. Hum Reprod 2001; 16(5): 1020-1026.

Grumbach MM, Styne DM. Puberty: ontogeny, neuroendocrinology, physiology, and disorders. In: Wilson JD, Foster DW, Kronenberg HM, Larsen PR, Eds. William's Textbook of Endocrinology. Philadelphia: W.B. Saunders Company. 1998; 1509-1625.

Garn SM, Haskell JA. Fat and growth during childhood. Science 1959; 130: 1711-1712.

Marshall E. Epidemiology. Search for a killer: focus shifts from fat to hormones. Science 1993; 259(5095): 618-621.

Selevan SG, Rice DC, Hogan KA, Euling SY, Pfahles-Hutchens A, Bethel J. Blood lead concentrations and delayed puberty in girls. N Engl J Med 2003; 348(16): 1527-1536.

Blanck HM, Marcus M, Tolbert PE, Rubin C, Henderson AK, Hertzberg VS, Zhang RH, Cameron L. Age at menarche and Tanner stage in girls exposed in utero and postnatally to polybrominated biphenyl. Epidemiology 2000; 11(6): 641-647.

Proos LA, Hofvander Y, Tuvemo T. Menarcheal age and growth pattern of Indian girls adopted in Sweden. Acta Paediatr Scand 1991; 80(8-9): 852-858.

Krstevska-Konstantinova, Craen M, Beckers D, Du Caju M, Heinrichs C, de Beaufort C, Bourguignon JP. Growth pattern in idiopathic central precocious puberty: a comparison between Belgian native and adopted girls. 1998; Horm Res 50 (Suppl. 3): 130.

Krstevska-Konstantinova M, Craen M, Beckers D, Du Caju M, Heinrichs C, de Beaufort C, Bourguignon JP. Precocious puberty in adopted and non-adopted foreign girls moving to Belgium: a role for environmental factors independent of recovery from deprivation. 1999; Horm Res 51(Suppl 2): 71.

Saenz de Rodriguez CA, Bongiovanni AM, Conde de Borrago L. An epidemic of precocious development in Puerto Rican children. J Pediatr 2000; 107(3): 393-396.

Natural Resources Defense Council. Environment and Health: Health Effects of Pollution: In Brief: FAQ, Endocrine Disruptors ( http://www.nrdc.org/health/effects/gendoc.asp

National Toxicology Program, Center for Evaluation of risks to human reproduction. Final CERHR expert panel reports on 7 phthalate esters ( http://cerhr,niehs,gov/news/index.html

McLachlan JA. Estrogenic properties of DDT and its analogs. In: McLachlan JA, ED. Estrogens in the Environment. New York: Elsevier/North-Holland. 1980; 239-263.

Tamir S, Eizenberg M, Somjern D, Stern N, Shelach R, Kaye A, Vaya J. Estrogenic and antiproliferative proglabridin from licorice in human breast cancer cells. Cancer Res 2000; 60(20): 5704-5709.

Kulin HE, Reiter EO. Gonadotropin and testosterone measurements after estrogen administration to adult men, prepubertal and pubertal boys, and men with hypogonadotropism: evidence for maturation of positive feed-back in the male. Pediatr Res 1976; 10(1): 46-51.

Mauras N, Rogol AD, Veldhius JD. Estrogenic modulation of the gonadotropin-releasing hormonestimulated secretory activity of the gonadotrope and lactotrope in prepubertal females with Turner's syndrome. J Clin Endocrinol Metab 1991; 73(6): 1202-1209.

Bitman J, Cecil HC, Harris SJ, Fries GF. Estrogenic activity of o,p'-DDT in the mammalian uterus and avian oviduct. Science 1968; 162(851): 371-372.

Gellert RJ, Heinrichs WL, Swerdloff RS. DDT homologues: estrogen-like effects on the vagina, uterus, and pituitary of the rat. Endocrinology 1972; 91(4): 1095-1100.

Clark EJ, Norris DO, Jones RE. Interactions of gonadal steroids and pesticides (DDT, DDE) on gonaduct growth in larval Tiger Salamanders, Ambystoma tigrium.Gen Comp Endocrinol 1998; 109(1): 94-105.

Charlier C. Endocrine effects of environmental pollutants. Bull Mem Acad R Med Belg 2005; 160(5-6): 301-310.

Brown NM, Lamartiniere CA. Xenoestrogens alter mammary gland differentiation and cell proliferation in the rat. Environ Health Perspect 1995; 103(7-8): 708-713.

Parent AS, Rasier G, Gerard A, Heger S, Roth C, Mastronardi C, Jung H, Ojeda SR, Bourguignon JP. Early onset of puberty: tracking genetic and environmental factors. Horm Res 2005; 64(Suppl 2): 41-47.

Rogan WJ, Ragan NB. Evidence of effects of environmental chemicals on the endocrine system in children. Pediatrics 2003; 112(1 Pt 2): 247-252.

Colon I, Caro D, Bourdony CJ, Rosario O. Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development. Environ Health Perspect 2000; 108(9): 895-900.

Den Hond E, Roels HA, Hoppenbrouwers K, Nawrot T, Thijs L, Vandermulen C, Winnecke G, Vanderschueren D, Staessen JA. Sexual maturation in relation to polychlorinated aromatic hydrocarbons: Sharpe and Skakkebaek's hypothesis revisited. Environ Health Perspect 2002; 110(8): 771-776.

Key T, Reeves G. Organochlorines in the environment and breast cancer. Br Med J 1994; 308(6943): 1520-1521.

Eddleston M, Karalliedde L, Buckley N, Fernando R, Hutchinson G, Isbister G, Konradsen F, Murray D, Piola JC, Senayake N, Sheriff R, Singh S, Siwach SB, Smit L. Pesticide poisoning in the developed world: a minimum pesticide list. Lancet 2002; 360(9430): 1163-1167.

National implementation plan on reduction and elimination of POPs in the Republic of Macedonia. Ministry of Environment and Physical Planning. 2004.

Balkan Journal of Medical Genetics

The Journal of Macedonian Academy of Sciences and Arts

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