Quality assurance of Mo-99/Tc-99m radionuclide generators

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Abstract

Gamma-ray spectrometry analyses of the radionuclide content of eluate from two Mo-99/Tc-99m radionuclide generators POLTECHNET have been performed. The relative activities of 99Mo 103Ru and 131I radioisotopes with respect to the activity of 99mTc at different time intervals after the primary pertechnetate elution of the generators have been analyzed. The relative activities of the isotopes were determined and compared to the radionuclidic purity requirements for 99mTc.

[1]. Segrè, Emilio; Seaborg, Glenn T., Nuclear Isomerism in Element 43, Physical Review 1938 54 (9), 772–772.

[2]. Eckelman, W. C., Unparalleled Contribution of Technetium-99m to Medicine Over 5 Decades, JACC: Cardiovascular Imaging 2009 2 (3), 364–368, doi:10.1016/j.jcmg.2008.12.013.

[3]. Arano, Y., Recent advances in Tc-99m radio pharmaceuticals, Annals of Nuclear Medicine 2002 16(2):79-93.

[4]. Banerjee, S; Pillai, M.R.A.; Ramamoorthy, N, Evolution of Tc-99m in diagnostic radiopharmaceuticals, Seminars in Nuclear Medicine 2001 31(4):260-277.

[5]. Saha, G; Fundamentals of Nuclear Pharmacy, Published by Springer New York 2004 ISBN: 978-0-387-40360-1, DOI: 10.1007/b97503.

[6]. Production technologies for molybdenum-99 and technetium-99m, IAEA-TECDOC-1065

[8]. Council of Europe (2005a) Sodium pertechnetate [99mTc] injection (fission). Monograph No. 124, European Pharmacopoeia, 5th edn., Maisonneuve, Sainte-Ruffine

[9]. Council of Europe (2005b) Sodium pertechnetate [99mTc] injection (nonfission). Monograph No. 283. European Pharmacopoeia, 5th edn. Maisonneuve, Sainte-Ruffine

[10]. Briner WH, Harris CC (1974) Radionuclide contamination of eluates from fission-product molyb denum-technetium generators. J Nucl Med 15:466±467

[11]. IAEA. 2002, Specialized software utilities for gamma ray spectrometry. Final report of a co-ordinated research project 1996–2000, IAEA-TECDOC-1275, International Atomic Energy Agency, Vienna, Austria.

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