Redox and Immunological Status of Turkeys Fed Diets with Different Levels and Sources of Copper

Open access

Abstract

This study, performed on turkeys aged 1 to 98 days, aimed to investigate whether different dietary inclusion levels (20, 10, 2 mg kg−1) of copper nanoparticles (Cu-NP) as a substitute for copper sulphate (Cu-SUL) affect redox and immunological status of turkeys’ tissues. No significant differences in the final body weights of turkeys were found across the dietary treatments. A comparison of the physiological effects of Cu-NP and Cu-SUL revealed equivocal metabolic responses including decreased superoxide dismutase (SOD) activity in the liver, increased SOD and catalase activities in breast muscles, decreased total glutathione concentrations in breast muscles, and decreased plasma IgY concentrations. An analysis of the antioxidant and immune status parameters in the blood, liver and breast meat of turkeys indicates that 10 mg/kg is the optimal inclusion level of additional Cu. Both two-fold higher and five-fold lower Cu supplementation levels have a negative influence on selected parameters of the antioxidant and immune status of birds. Lower supplementation levels of Cu-NP (2 and 10 mg/kg) exert similar physiological effects to Cu-SUL, whereas higher addition of Cu-NP (20 mg/kg) may negatively affect selected redox parameters and stimulate the synthesis of the proinflammatory cytokine IL-6. The results of the present study indicate that further research is needed to establish the actual dietary requirements for Cu in turkeys and the efficacy of nanoparticles as a new additional Cu source in turkey nutrition.

Ajuwon O.R., Idowu O.M.O., Afolabi S.A., Kehinde B.O., Oguntola O.O., Olatun-bosun K.O. (2011). The effects of dietary copper supplementation on oxidative and antioxidant systems in broiler chickens. Arch. Zootec., 60: 275–282.

Albanese A., Tang P.S., Chan W.C.W. (2012). The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu. Rev. Biomed. Eng., 14: 1–16.

Amstad P., Moret R., Cerutti P. (1994). Glutathione peroxidase compensates for the hypersensitivity of Cu, Zn-superoxide dismutase overproducers to oxidant stress. J. Biol. Chem., 269: 1606–1609.

Bao Y.M., Choct M., Iji P., Bruerton A. (2007). Effect of organically complexed copper, iron, manganese and zinc on broiler performance, mineral excretion and accumulation in tissues. J. Appl. Poultry Res., 16: 448–455.

Bunglavan S.J., Dass A.K.G., Shrivastava S. (2014). Use of nanoparticles as feed additives to improve digestion and absorption in livestock. Livestock Res. Int., 2: 36–47.

Dinant H.J., Dijkmans B.A.C. (1999). New therapeutic targets for rheumatoid arthritis. Pharm. World Sci., 21: 49–59.

EFSA, Panel on Additives and Products or Substances used in Animal Feed (FEEDAP). (2016). Revision of the currently authorised maximum copper content in complete feed. EFSA J., 14: 4563.

El Sabry M.I., Mc Millin K.W., Sabliov C.M. (2018). Nanotechnology considerations for poultry and livestock production systems – a review. Ann. Anim. Sci., 18: 319–334.

Freedman J.H., Wolterbeek H.T. (1989). The role of glutathione in copper metabolism and toxicity. J. Biol. Chem., 264: 5590–5605.

Hill E.K., Li J. (2017). Current and future prospects for nanotechnology in animal production. J. Anim. Sci. Biotechnol., 8: 26.

Hussain N., Jaitley V., Florence A.T. (2001). Recent advances in the understanding of uptake of microparticles across the gastrointestinal lymphatics. Adv. Drug Deliv. Rev., 50: 107–142.

Hybrid Turkeys (2013). Nutrient Guidelines. http://resources.hybridturkeys.com/nutrition/commercial-guidelines (accessed 09.07.2018).

Kim J.W., Chao P.Y., Allen A. (1992). Inhibition of elevated hepatic glutathione abolishes copper deficiency cholesterolemia. FASEB J., 6: 2467–2471.

Klasing K.C. (1998). Nutritional modulation of resistance to infectious diseases. Poultry Sci., 77: 1119–1125.

Maheshwari S. (2013). Environmental impacts of poultry production. Poult. Fish Wildl. Sci., 1: 101–103.

Majewski M., Ognik K., Zduńczyk P., Juśkiewicz J. (2017). Effect of dietary copper nanoparticles versus one copper (II) salt: analysis of vasoreactivity in a rat model. Pharmacol. Rep., 69: 1282–1288.

Makarski B., Gortat M., Lechowski J.,Żukiewicz-Sobczak W., Sobczak P., Zawiślak K. (2014). Impact of copper (Cu) at the dose of 50 mg on haematological and biochemical blood parameters in turkeys, and level of Cu accumulation in the selected tissues as a source of information on product safety for consumers. Ann. Agric. Environ. Med., 21: 567–570.

Malavolta M., Piacenza F., Basso A., Giacconi R., Costarelli L., Mocchegia-ni E. (2015). Serum copper to zinc ratio: relationship with aging and health status. Mech. Ageing. Dev., 151: 93–100.

Mc Cord J.M. (1983). The superoxide free radical: its biochemistry and pathophysiology. Surgery, 94: 412–414.

Mikulski D., Jankowski J., Zduńczyk Z., Wróblewska M., Mikulska M. (2009). Copper balance, bone mineralization and the growth performance of turkeys fed diet with two types of Cu supplements. J. Anim. Feed Sci., 18: 677–688.

Nollet L., Huyghebaert G., Spring P. (2008). Effect of different levels of dietary organic (Biolpex) trace minerals on live performance of broiler chickens by growth phases. J. Appl. Poultry Res., 17: 109–115.

NRC (1994). Nutrient Requirements of Poultry. 9th rev. ed. Natl. Acad. Press, Washington, DC.

Ognik K., Wertelecki T. (2012). Effect of different vitamin E sources and levels on selected oxidative status indices in blood and tissues as well as on rearing performance of slaughter turkey hens. J. Appl. Poultry Res., 2: 259–271.

Ognik K., Stępniowska A., Cholewińska E., Kozłowski K. (2016). The effect of administration of copper nanoparticles to chickens in drinking water on estimated intestinal absorption of iron, zinc, and calcium. Poultry Sci., 95: 2045–2051.

Percival S.S. (1998). Copper and immunity. Am. J. Clin. Nutr., 67: 1064S–1068S.

Samanta B., Ghosh P.R., Biswas A., Das S.K. (2011). The effects of copper supplementation on the performance and hematological parameters of broiler chickens. Asian-Australas. J. Anim. Sci., 24: 1001–1006.

Smulikowska S., Rutkowski A. (2005). Recommended Allowances and Nutritive Value of Feedstuffs – Poultry Feeding Standards (in Polish). 5th ed. Smulikowska, S., Rutkowski, A., Eds. The Kielanowski Institute of Animal Physiology and Nutrition, Jablonna, PAS, Poland.

Sunderman Jr F.W., Nomoto S. (1970). Measurement of human serum ceruloplasmin by its p-phenylenediamine oxidase activity. Clin. Chem., 16: 903–910.

Tomaszewska E., Muszyński S., Ognik K., Dobrowolski P., Kwiecień M., Juśkiewicz J., Chocyk D., Świetlicki M., Blicharski T., Gładyszewska B. (2017). Comparison of the effect of dietary copper nanoparticles with copper (II) salt on bone geometric and structural parameters as well as material characteristics in a rat model. J. Trace Elem. Med. Biol., 42: 103–110.

Wang C., Wang M.Q., Ye S.S., Tao W.J., Du Y.J. (2011). Effects of copper-loaded chitosan nanoparticles on growth and immunity in broilers. Poultry Sci., 90: 2223–2228.

Xiang-Qi Z., Zhang K.-Y., Ding X.-M., Bai S.-P. (2009). Effects of dietary supplementation with copper sulfate or tribasic copper chloride on carcass characteristics, tissular nutrients deposition and oxidation in broilers. Pakistan J. Nutr., 8: 1114–1119.

Annals of Animal Science

The Journal of National Research Institute of Animal Production

Journal Information


IMPACT FACTOR 2017: 1.018
5-year IMPACT FACTOR: 0.959



CiteScore 2017: 1.01

SCImago Journal Rank (SJR) 2017: 0.413
Source Normalized Impact per Paper (SNIP) 2017: 0.822

Metrics

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 114 114 48
PDF Downloads 89 89 40