Aging Process in Chromatin of Animals

Maciej Wnuk, Monika Bugno-Poniewierska, Anna Lewińska 4 , Bernadetta Oklejewicz, Tomasz Ząbek 3 ,  and Ewa Słota
  • 1 Department of Genetics, University of Rzeszow, Rejtana 16C, 35-959 Rzeszów, Poland
  • 2 Centre of Applied Biotechnology and Basic Sciences, University of Rzeszow, Sokołowska 26, 36-100 Kolbuszowa, Poland
  • 3 Laboratory of Genomics, National Research Institute of Animal Production, 32-083 Balice n. Kraków, Poland
  • 4 Department of Biochemistry and Cell Biology, University of Rzeszow, Rejtana 16C, 35-959 Rzeszów, Poland

Aging Process in Chromatin of Animals

The aging process is a variable, stochastic and pleiotropic phenomenon which is regulated by different environmental and genetic factors. The age-associated changes, which occur at the molecular and cellular levels and disturb biological homeostasis, may directly or indirectly contribute to aging, causing apoptosis or cellular senescence and consequently leading to the death of the organism. In this context, it is particularly interesting to observe changes in somatic cell chromatin. In the present paper, we summarized the knowledge on the biological aspects of aging with special consideration of age-related changes in chromatin like DNA damage, shortening telomeres or age-related changes in methylation of DNA.

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