Surgical Risk Factors of Patients with Operable Gist

Open access

Abstract

Introduction: Gastrointestinal stromal tumors (GIST) are the most frequently mezenchimale tumors of the gastrointestinal tract. This study aims to analyze the results after surgical treatment of GIST and identify key risk factors influencing postoperative course of these patients in order to discover the most effective therapeutic methods to significantly improve postoperative course of these patients.

Methods: We retrospectively reviewed the medical records of all patients who underwent surgical removal of GISTs from 2004-2014. Patient demographics, criterion for admission, surgery, complications, secondary dissemination, histopathological data and clinical course were analized following patient survival at 12, 24, 36 and to 60 months postoperatively. Statistical analysis was performed using the MedCalc software program, and survival analysis was done by Kaplan Meyer.

Results: During this period we analyzed a total of 28 cases, including 13 males and 15 females with age from 33 to 80 years (median, 61). The tumor was located in the stomach (15 cases; 53%), small intestine in ten cases (36%) and other sites in three patients (11%). Multivariate analysis revealed that tumor size (P <0,05), criterion for admission (P<0,05) and secondary dissemination (P<0,05) are independed prognostic factors.

Conclusions: Factors like: age and sex of patients, size and tumor site, presence or absence of metastasis, are prognostic risk factors with significant differences in the evolution of patients with operable GIST. The small number of patients and retrospective nature of the study have created difficulties in the estimation where we concluded the need of a prospective multicentric study.

1. M. Al-Kalaawy, Mohamed A, Ahmed M, A. Al-Kalaawy, H. El-Sebae. Gastrointestinal Stromal tumors (GISTs), 10-year experience: Patterns of failures and prognostic factors for survival of 127 patients. J of the Egyptian Nat Cancer Institute, 2012;24:31-39

2. Cao H, Zhang Y, Wang M, Shen D, Sheng Z, Ni X, Wu Z, Liu Q, Shen Y, Song Y. Prognostic analysis of patients with gastrointestinal stromal tumors: a single unit experience with surgical treatment of primary disease. Chin Med J, 2010;123:131-136

3. Eligijus P, Pavel P, Egle P, Vytautas L, Juozas S, Kestutis S. Surgical management of gastrointestinal stromal tumors: a single center experience. Videosurgery Miniiv, 2014; 9:71-82.

4. Ting W, Li L, Chun Y, Pei W, Tzu C, Tsann H, Yi J, Miin C. Surgical treatment and prognostic analysis for gastrointestinal stromal tumors (GISTs) of the samll intestine: before the era of imatinib mesylate. BMC Gastroenterology 2006, 6:29 doi: 10.1186/1471-230X-6-29

5. Minzhi Lv, Chunxiao Wu, Ying Z, Naiqing Z. Incidence and Survival Analysis of Gastrointestinal Stromal Tumors in Shangai: A Population Based Study from 2001 to 2010. Gastroenterology Research and Practice, 2014; Art ID 834136

6. Naoki T, Kazuaki T, Takahisa S, Noriaki T, Hideki O. Prognostic criteria in patients with gastrointestinal stromal tumors: a single center experience retrospective analysis. World J. of Surg Oncol, 2012;10:43

7. Caterino S, Lorenzon L, Petrucciani N, Iannicelli E, Pilozzi E, Romiti A, Cavallini M, Ziparo V. Gastrointestinal stromal tumors: correlation between symptoms at presentation, tumor location and prognostic factors in 47 consecutive patients. World J of Surg Oncol 2011, 9:13

8. Unalp HR, Erdinc K HD, AliB, Ercument T, Mehmet O. Gastrointestinal stromal tumours: outcomes of surgical management and analysis of prognostic variables. Can J Surg, 52

9. Pleşea IE, Chiuţu L, Bordu SI, Georgescu I, Georgescu EF, Ciobanu D, Mărgăritescu ND, Comănescu V, Nemeş R. Gastrointestinal stromal tumors- a clinical-morphological study on 15 cases. Rom J Morphol Embryol 2014;55:513-523.

10. Zhen H, Yuan Li, Hong Z, Jian Z, Jian C. Prognostic factors and clinicopathological characteristics of small gastrointestinal stromal tumor of the stomach: a retrospective analysis of 31 cases in one center. Cancer Biol Med 2013;10:165-168.

Acta Medica Marisiensis

The Journal of The University of Medicine and Pharmacy of Targu-Mures

Journal Information

Metrics

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 90 90 16
PDF Downloads 19 19 4