Melatonin Improves Liver Function in Benzene-Treated Rats

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In this study, we investigated the beneficial effects of melatonin against benzene-induced liver function impairments in Wistar rats. After 30 days of treatment, it significantly lowered hepatosomatic indices, bilirubin, and hydroxyproline in male and female benzene-treated rats. Even though it did not influence aspartate aminotransferase, melatonin had beneficial effects on alanine aminotransferase and alkaline phosphatase. Our results suggest that melatonin is an effective modulator of liver function in benzenetreated rats thanks to its antioxidative properties.

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Archives of Industrial Hygiene and Toxicology

The Journal of Institute for Medical Research and Occupational Health

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