Lead Toxicity in a Family as a Result of Occupational Exposure

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Lead Toxicity in a Family as a Result of Occupational Exposure

This article describes an entire family manufacturing lead acid batteries who all suffered from lead poisoning. The family of five lived in a house, part of which had been used for various stages of battery production for 14 years. Open space was used for drying batteries. They all drank water from a well located on the premises. Evaluation of biomarkers of lead exposure and/or effect revealed alarming blood lead levels [(3.92±0.94) μmol L-1], 50 % reduction in the activity of δ-aminolevulinic acid dehydratase [(24.67±5.12) U L-1] and an increase in zinc protoporphyrin [(1228±480) μg L-1]. Liver function tests showed an increase in serum alkaline phosphatase [(170.41±41.82) U L-1]. All other liver function test parameters were normal. Renal function tests showed an increase in serum uric acid [(515.81±86.29) μmol L-1] while urea and creatinine were normal. Serum calcium was low [(1.90±0.42) mmol L-1 in women and (2.09±0.12) mmol L-1 in men], while blood pressure was high in the head of the family and his wife and normal in children. Lead concentration in well water was estimated to 180 μg L-1. The family was referred to the National Referral Centre for Lead Poisoning in India, were they were received treatment and were informed about the hazards of lead poisoning. A follow up three months later showed a slight decrease in blood lead levels and a significant increase in haemoglobin. These findings can be attributed to behavioural changes adopted by the family, even though they continued producing lead batteries.

World Health Organization (WHO). Inorganic lead. Geneva: World Health Organization; Environ Health Criteria 165; 1995.

Lewis J. Lead poisoning: A Historical Perspective. EPA Journal - May 1985. http://www.epa.gov/history/topics/perspect/lead.htm

Hernberg S. Lead Poisoning in a Historical Perspective. Am J Ind Med 2000;38,244-54.

Clark CS, Rampal KG, Thuppil V, Chen CK, Clark R, Roda S. The lead content of currently available new residential paint in several Asian countries. Environ Res 2005;102:9-12.

Clark CS, Thuppil V, Clark R, Sinha S, Menezes G, et al. Lead in Paint and Soil in Karnataka and Gujarat, India. J Occ Environ Hyg 2005;2: 38-44.

Goyer RA. Lead toxicity: Current concerns. Environ Health Perspect 1993;100:177-87.

Rabinowitz MB, Wetherill GW, Kopple JD. Kinetic analysis of lead metabolism in healthy humans. J Clin Invest 1976;58:260-70.

Papanikolaou NC, Hatzidaki EG, Belivanis S, Tzanakakis GN, Tsatsakis AM. Lead toxicity update. A brief review. Med Sci Monit 2005;11:RA329-36.

Goldfrank LR, Flomenbaum NE, Lewin NA, Weisman RS, Howland MA, Hoffman RS. Goldfrank's Toxicologic Emergencies. 6th edition. Appleton & Lange: Stanford (CT);1998;1227-309.

Agency for Toxic Substances and Disease Registry. Toxicological profile for lead. Atlanta: US Department of Health and Human Services, Public Health Service; 2005.

Gittleman JL, Engelgau MM, Shaw J, Wille KK, Seligman PJ. Lead poisoning among battery reclamation workers in Albama. J Occup Med 1994;36:526-532.

DžSouza HS, Menezes G, Venkatesh T. Fetal Lead Exposure: Encephalopathy in a Child. Indian J Clin Biochem 2002;17:9-11.

Flora SJS. Background of Lead sources in India. Proceedings of the International Conference on Lead Poisoning, Prevention and Treatment; February 8-10. 1999.; Bangalore, India. 224-226.

Thuppil Venkatesh. The effects of environmental lead on human health: a challenging Scenario. Environ Health Focus 2004;2(1):8-16.

Staudinger KC, Roth VS. Occupational lead poisoning. Am Fam Physician 1998;57:719-26.

Gidlow DA. Lead toxicity in depth review. Occup Med 2004;54:76-81.

Jagner D, Graneli A. Potentiometric stripping analysis. Anal Chim Acta 1976;83:19-26.

Drabkins DL, Austin JM. Spectrophotometric constants for common hemoglobin derivatives in human, dog and rabbit blood. J Biol Chem 1932;98:719-23.

Berlin A, Schaller KH. European standardized method for the determination of δ-aminolevulinic acid dehydratase activity. Klin Chem Klin Biochem 1974;12:389-90.

Blumberg WE, Eisinger J, Lamola AA, and Zukerman DM. The Hematofluorometer. Clin Chem 1977;23:270-4.

Chen JianRong, Xiao Shanmei, Wu XiaoHua, Fang KeMing, Liu WenHan. Determination of lead in water samples by graphite furnase atomic absorption spectrometry after cloud point extraction. Talanta 2005;67:992-6.

Occupational Safety and Health Administration (OSHA). Employee standard summary - 1910.1025 App B. [displayed 6th January 2008]. Available at http://www.osha.gainfotech.edu/lead/lead-appB.pdf

de Siqueira MEPB, Maia PP, de Oliveira DP, and Luengo DML. Delta-aminolevulinic acid dehydratase activity in the general population of Southern Minas Gerais, Brazil. Ind Health 2003;41:19-23.

Norbert WTietz., editor. Clinical guide to laboratory tests. 3rd ed. Philadelphia: W. B. Saunders Company; 1995.

Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for lead. Atlanta: US Department of Health and Human Services, Public Health Service; 2005.

Graziano JH, Slavkovic V, Factor-Litvak P, Popovac D, Ahmedi X, Mehmeti A. Depressed serum erythropoietin in pregnant women with elevated blood lead. Arch Environ Health 1991;46:347-50.

Paglia DE, Valentine WN, Dahlgner JG. Effects of low level lead exposure on pyrimidine-5' nucleotidase and other erythrocyte enzymes. J Clin Invest 1976;56:1164-9.

Piomelli S. Childhood lead poisoning. Pediatr Clin North Am 2002;49:1285-304.

Piomelli S, Wolff JA. Childhood lead poisoning in the '90s. Pediatrics 1994;93:508-10.

Marcus AH, Schwartz J. Dose-response curves for erythrocyte Protoporphyrin vs. blood lead: effects of iron status. Environ Res 1987;44:221-7.

Schwartz J. Lead, blood pressure and cardiovascular disease in men. Arch Environ Health 1995;50:31-7.

Korrick SA, Hunter DJ, Rotnizky A et al. Lead and hypertension in a sample of middle aged women. Am J Public Health 1999;89:330-5.

Simons TJB. Cellular interactions between lead and calcium. Br Med Bull 1986;42:431-4.

Bennet WM. Lead nephropathy. Kidney Int 1985;28:212-20.

Archives of Industrial Hygiene and Toxicology

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